Helliwell, PS and Kavanaugh, A (2018) Radiographic progression is less in psoriatic arthritis achieving a good response to treatment: data using newer composite indices of disease activity. Arthritis Care & Research, 70 (5). pp. 797-800. ISSN 2151-464X
Abstract
Objectives: The purpose of this study was to compare radiographic outcomes according to the magnitude of the response utilizing three new psoriatic composite disease activity measures (the Psoriatic Arthritis Disease Activity Score (PASDAS), the GRAPPA Composite Exercise (GRACE), and the Disease Activity in PsA (DAPSA). The data were taken from the GO-REVEAL dataset, a large randomised, double-blind, study which evaluated the safety and efficacy of 2 doses of the TNF inhibitor golimumab in subjects with active PsA. Methods: Response criteria at 24 weeks were applied across the whole dataset, irrespective of treatment group. Radiographic scores at baseline and 24 weeks were assessed using the Sharp van der Heijde method, modified for PsA. Results: Overall, for each measure, radiographic progression was significantly greater in subjects with a moderate or poor outcome, and absent in those with a good outcome. The proportion of subjects without radiographic progression in the good outcome group was: PASDAS, 83%, χ2 = 7.9, p = 0.02; GRACE, 80%, χ2 = 5.8, p = 0.05; DAPSA, 76% χ2 = 3.4, p = 0.19. Conclusions: Response criteria for disease specific composite measures enable separation between groups in terms of radiographic progression and may therefore be used as suitable targets for interventional studies, as well as in the clinic.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2017, American College of Rheumatology. This is the peer reviewed version of the following article: Helliwell, P. S. and Kavanaugh, A. (2017), Radiographic progression is less in psoriatic arthritis achieving a good response to treatment: data using newer composite indices of disease activity. Arthritis Care Res. doi:10.1002/acr.23345, which has been published in final form at https://doi.org/10.1002/acr.23345. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | psoriasis; psoriatic arthritis; outcome measures; TNF inhibitors; golimumab; radiographic scoring |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 27 Sep 2017 08:56 |
Last Modified: | 22 Aug 2018 00:38 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/acr.23345 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:121751 |