Smith, S.A., Samokhin, A.O., Alfadi, M. et al. (7 more authors) (2017) The IL-1RI co-receptor TILRR (FREM1 isoform 2) controls aberrant inflammatory responses and development of vascular disease. JACC: Basic to Translational Science, 2 (4). pp. 398-414.
Abstract
Summary Expression of the interleukin-1 receptor type I (IL-1RI) co-receptor Toll-like and interleukin-1 receptor regulator (TILRR) is significantly increased in blood monocytes following myocardial infarction and in the atherosclerotic plaque, whereas levels in healthy tissue are low. TILRR association with IL-1RI at these sites causes aberrant activation of inflammatory genes, which underlie progression of cardiovascular disease. The authors show that genetic deletion of TILRR or antibody blocking of TILRR function reduces development of atherosclerotic plaques. Lesions exhibit decreased levels of monocytes, with increases in collagen and smooth muscle cells, characteristic features of stable plaques. The results suggest that TILRR may constitute a rational target for site- and signal-specific inhibition of vascular disease.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY 4.0 LICENSE ( http://creativecommons.org/licenses/by/4.0/ ) . |
Keywords: | heparan sulfate proteoglycan; interleukin-1 receptor; IL-1RI; NF-κB; TILRR |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number BRITISH HEART FOUNDATION PG/11/103/29219 BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL (BBSRC) BB/J009687/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 05 Sep 2017 15:21 |
Last Modified: | 13 Jan 2020 12:05 |
Published Version: | https://doi.org/10.1016/j.jacbts.2017.03.014 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.jacbts.2017.03.014 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:120877 |