Mechanism of regulation of pantothenate biosynthesis by the PanD-PanZ.AcCoA complex reveals an additional mode of action for the antimetabolite N-pentyl pantothenamide (N5-Pan)

Arnott, ZLP, Nozaki, S, Monteiro, DCF et al. (4 more authors) (2017) Mechanism of regulation of pantothenate biosynthesis by the PanD-PanZ.AcCoA complex reveals an additional mode of action for the antimetabolite N-pentyl pantothenamide (N5-Pan). Biochemistry, 56 (37). pp. 4931-4939. ISSN 0006-2960

Abstract

Metadata

Authors/Creators:
Copyright, Publisher and Additional Information: © 2017 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that will appear in final form in Biochemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.biochem.7b00509. Uploaded in accordance with the publisher's self-archiving policy.
Keywords: Metabolic regulation; antimetabolites; antibiotics; vitamin biosynthesis; Pyruvoyl-dependent enzymes
Dates:
  • Published: 19 September 2017
  • Accepted: 23 August 2017
  • Published (online): 23 August 2017
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds)
The University of Leeds > Faculty of Maths and Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds)
Funding Information:
FunderGrant number
Wellcome Trust096684/Z/11/Z
Wellcome Trust094232/Z/10/Z
Wellcome Trust105615/Z/14/Z
Depositing User: Symplectic Publications
Date Deposited: 30 Aug 2017 09:52
Last Modified: 23 Aug 2018 00:38
Status: Published
Publisher: American Chemical Society
Identification Number: https://doi.org/10.1021/acs.biochem.7b00509

Share / Export

Statistics