Singh, V., Davidson, A.C., Hume, P.J. et al. (2 more authors) (2017) Arf GTPase interplay with Rho GTPases in regulation of the actin cytoskeleton. Small GTPases, 10 (6). pp. 411-418. ISSN 2154-1248
Abstract
The Arf and Rho subfamilies of small GTPases are nucleotide-dependent molecular switches that act as master regulators of vesicular trafficking and the actin cytoskeleton organization. Small GTPases control cell processes with high fidelity by acting through distinct repertoires of binding partners called effectors. While we understand a great deal about how these GTPases act individually, relatively little is known about how they cooperate, especially in the control of effectors. This review highlights how Arf GTPases collaborate with Rac1 to regulate actin cytoskeleton dynamics at the membrane via recruiting and activating the Wave Regulatory Complex (WRC), a Rho effector that underpins lamellipodia formation and macropinocytosis. This provides insight into Arf regulation of the actin cytoskeleton, whilst putting the spotlight on small GTPase cooperation with emerging evidence of its importance in fundamental cell biology and interactions with pathogenic bacteria.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Author(s). This is an Accepted Manuscript of an article published by Taylor & Francis in Small GTPases on 19 May 2017, available online: http://www.tandfonline.com/10.1080/21541248.2017.1329691. |
Keywords: | Actin cytoskeleton, Arf and Rho GTPases, Wave regulatory complex, Salmonella, EPEC and bacterial effector proteins |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 24 Jul 2017 15:05 |
Last Modified: | 31 Jul 2023 15:18 |
Status: | Published |
Publisher: | Taylor & Francis |
Refereed: | Yes |
Identification Number: | 10.1080/21541248.2017.1329691 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:118946 |