Tribbles in inflammation

Abstract

Inflammation is part of the physiological innate immune response to invading pathogens and tissue injury. However, unresolved inflammation leads to human disease. The tribbles (TRIB) family of pseudokinase proteins has been shown to modulate key inflammatory signalling pathways, including the MAPK (mitogenactivated protein kinase) and PI3K (phosphoinositide 3-kinase) networks. This review summarizes our current knowledge on TRIBs in the context of inflammation, both at the level of molecular mechanisms and in disease development.

Metadata

Item Type:	Article
Authors/Creators:	Johnston, J.R. Basatvat, S. Ilyas, Z. Francis, S. https://orcid.org/0000-0001-6552-0339 Kiss-Toth, E. https://orcid.org/0000-0003-4406-4017
Copyright, Publisher and Additional Information:	© 2015 Authors
Keywords:	chronic inflammation; disease; mitogen-activated protein kinase (MAPK); tribbles
Dates:	Published: 9 October 2015
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals
Depositing User:	Symplectic Sheffield
Date Deposited:	13 Jul 2017 13:41
Last Modified:	13 Jul 2017 13:41
Published Version:	http://doi.org/10.1042/BST20150095
Status:	Published
Publisher:	Portland Press
Refereed:	Yes
Identification Number:	10.1042/BST20150095
Related URLs:	Author
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:118222

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Tribbles in inflammation

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