Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage

Chiang, S.C., Meagher, M. orcid.org/0000-0001-7552-9054, Kassouf, N. orcid.org/0000-0003-0519-1929 et al. (4 more authors) (2017) Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage. Science Advances, 3 (4). e1602506.

Abstract

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Authors/Creators:
Copyright, Publisher and Additional Information: 2017 © The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Keywords: topoisomerase ; TDP1 ; mitochondria ; DNA repair ; ROS ; neurodegeneration ; cancer ; SCAN1 ; XRCC1 ; ataxia
Dates:
  • Published: 28 April 2017
  • Accepted: 2 March 2017
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biological Sciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 30 May 2017 14:47
Last Modified: 05 Nov 2018 14:08
Published Version: https://doi.org/10.1126/sciadv.1602506
Status: Published online
Publisher: American Association for the Advancement of Science
Refereed: Yes
Identification Number: https://doi.org/10.1126/sciadv.1602506
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