Mulhern, B., Labeit, A., Rowen, D.L. orcid.org/0000-0003-3018-5109 et al. (4 more authors) (2017) Developing preference-based measures for diabetes: DHP-3D and DHP-5D. Diabetic Medicine, 34 (9). pp. 1264-1275. ISSN 0742-3071
Abstract
Aims: The aim of this study was to develop two diabetes specific preference-based measures (Diabetes Health Profile - 3 Dimension; DHP-3D and the Diabetes Health Profile – 5 Dimension; DHP-5D) for use in the calculation of Quality Adjusted Life Years, a key outcome in economic evaluation. These measures were based on the non-preference-based instrument the Diabetes Health Profile.
Methods: For DHP-3D, psychometric and Rasch analyses were used to develop a health state classification system based on the DHP-18. The DHP-5D added two dimensions to the DHP-3D to extend the range of impacts measured. Each classification system was valued by 150 general public respondents in the United Kingdom using Time Trade Off. Multivariate regression was to estimate utility value sets. The matched dimensions across each measure were compared using z score tests.
Results: The DHP-3D included three dimensions defined as mood, eating and social limitations, and the DHP-5D added dimensions defined as hypoglycemic attacks and vitality. For both, the random effects generalized least squares regression model produced consistent value sets, with the DHP-3D and DHP- 5D ranging from 0.983 (best state) to 0.717(worst state), and 0.979 to 0.618 respectively. The addition of the two extra dimensions leads to significant differences for the more severe levels of each matched dimension.
Conclusions: We have developed two diabetes specific preference-based measures that, subject to psychometric assessment, can be used to provide condition specific utility values to complement generic utilities from more widely validated measures such as the EQ-5D.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Diabetes UK. This is an author produced version of a paper subsequently published in Diabetic Medicine. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | QALY; cost utility analysis; preference-based measure; time trade off; utility |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 10 May 2017 12:12 |
Last Modified: | 04 Aug 2023 10:28 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/dme.13377 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:116109 |