Mesquita, A., Cardenal-Muñoz, E., Dominguez, E. et al. (12 more authors) (2016) Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model. Autophagy, 13 (1). pp. 24-40. ISSN 1554-8627
Abstract
Autophagy is a fast-moving field with an enormous impact on human health and disease. Understanding the complexity of the mechanism and regulation of this process often benefits from the use of simple experimental models such as the social amoeba Dictyostelium discoideum. Since the publication of the first review describing the potential of D. discoideum in autophagy, significant advances have been made that demonstrate both the experimental advantages and interest in using this model. Since our previous review, research in D. discoideum has shed light on the mechanisms that regulate autophagosome formation and contributed significantly to the study of autophagy-related pathologies. Here, we review these advances, as well as the current techniques to monitor autophagy in D. discoideum. The comprehensive bioinformatics search of autophagic proteins that was a substantial part of the previous review has not been revisited here except for those aspects that challenged previous predictions such as the composition of the Atg1 complex. In recent years our understanding of, and ability to investigate, autophagy in D. discoideum has evolved significantly and will surely enable and accelerate future research using this model.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Taylor & Francis. |
Keywords: | Atg proteins; Dictyostelium; autophagic cell death; autophagy; infection; social amoeba |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
Funding Information: | Funder Grant number ROYAL SOCIETY RG130655 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 14 Dec 2017 11:40 |
Last Modified: | 14 Dec 2017 11:40 |
Published Version: | https://doi.org/10.1080/15548627.2016.1226737 |
Status: | Published |
Publisher: | Taylor & Francis |
Refereed: | Yes |
Identification Number: | 10.1080/15548627.2016.1226737 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:115618 |