Strong, Samantha L, Silson, Edward H, Gouws, Andre D et al. (2 more authors) (2017) Differential Processing of the Direction and Focus of Expansion of Optic Flow Stimuli in areas MST and V3A of the Human Visual Cortex. Journal of Neurophysiology. jn.00031.2017. ISSN 0022-3077
Abstract
Human neuropsychological and neuroimaging studies have raised the possibility that different attributes of optic flow stimuli, namely radial direction and the position of the focus of expansion (FOE), are processed within separate cortical areas. In the human brain, visual areas V5/MT+ and V3A have been proposed as integral to the analysis of these different attributes of optic flow stimuli. In order to establish direct causal relationships between neural activity in V5/MT+ and V3A and the perception of radial motion direction and FOE position, we used Transcranial Magnetic Stimulation (TMS) to disrupt cortical activity in these areas whilst participants performed behavioural tasks dependent on these different aspects of optic flow stimuli. The cortical regions of interest were identified in seven human participants using standard fMRI retinotopic mapping techniques and functional localisers. TMS to area V3A was found to disrupt FOE positional judgements, but not radial direction discrimination, whilst the application of TMS to an anterior sub-division of hV5/MT+, MST/TO-2, produced the reverse effects, disrupting radial direction discrimination but eliciting no effect on the FOE positional judgement task. This double dissociation demonstrates that FOE position and radial direction of optic flow stimuli are signalled independently by neural activity in areas hV5/MT+ and V3A.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017, Journal of Neurophysiology. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Keywords: | Journal Article |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Psychology (York) The University of York > Faculty of Sciences (York) > Psychology (York) > York Neuroimaging Centre |
Depositing User: | Pure (York) |
Date Deposited: | 24 Mar 2017 12:20 |
Last Modified: | 16 Oct 2024 13:40 |
Published Version: | https://doi.org/10.1152/jn.00031.2017 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1152/jn.00031.2017 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:114126 |