Santocildes-Romero, M.E., Hadley, L., Clitherow, K.H. et al. (5 more authors) (2017) Fabrication of electrospun mucoadhesive membranes for therapeutic applications in oral medicine. ACS Applied Materials and Interfaces, 9 (13). pp. 11557-11567. ISSN 1944-8244
Abstract
Oral mucosal lesions are related to several etiologies including trauma, infection, and immunologic and neoplastic diseases. Their prevalence varies greatly depending on ethnicity, gender and exposure to risk factors. Currently, most oral mucosal lesions are treated with creams, mouthwashes or gels containing suitable drugs. However, topical medications may be relatively ineffective as they are removed rapidly from oral surfaces, limiting drug contact times. Systemic medications might be more effective, but are associated with unacceptable off-target side effects. The aim of this study was to produce novel polymeric mucoadhesive membranes for therapeutic applications on the oral mucosa using electrospinning. Polyvinylpyrrolidone (PVP) and Eudragit RS100® (RS100) were used for the fabrication of membranes, whilst dextran (Dex) or poly(ethylene oxide) (PEO) particles were incorporated to enhance their mucoadhesive properties. An electrospun poly(caprolactone) (PCL) backing layer was added to create a dual-layer system. Solution properties were studied using rheometry, and membranes were characterized using differential thermal analysis and scanning electron microscopy. Solubility, surface hydrophobicity and adhesion properties were also investigated. Solution viscosity varied depending on composition and concentration, affecting fiber production. The addition of RS100 to PVP resulted in reduced membrane porosity and solubility, and increased surface hydrophobicity and in vitro adhesion times. Dex and PEO particles were located on the surface of the fibers. A PCL backing layer was successfully produced, with enhanced attachment between layers achieved through thermal treatment. PVP homopolymer membranes did not adhere to plastic or porcine mucosa, whereas PVP/RS100 membranes with and without PEO or Dex were tightly adherent. In conclusion, PVP and RS100 may be combined to tailor membrane properties. Furthermore, electrospinning facilitated the production of membranes consisting of mucoadhesive-fabricated fibers displaying increased surface area and long-lasting adhesive properties. These novel compositions exhibit great potential for the fabrication of mucoadhesive patches for therapeutic applications in oral medicine.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 American Chemcial Society. ACS AuthorChoice - This is an open access article published under an ACS AuthorChoice (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
Keywords: | Electrospinning; Membranes; Mucoadhesive; Oral medicine; Oral patches |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) EP/K029592/1 DERMTREAT NONE DERMTREAT UNSPECIFIED DERMTREAT UNSPECIFIED |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 21 Mar 2017 10:18 |
Last Modified: | 28 Jul 2023 14:25 |
Status: | Published |
Publisher: | American Chemical Society |
Refereed: | Yes |
Identification Number: | 10.1021/acsami.7b02337 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:113958 |