Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing

Jansen, IE, Ye, H, Heetveld, S et al. (71 more authors) (2017) Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biology, 18 (1). ISSN 1474-7596

Abstract

Metadata

Authors/Creators:
  • Jansen, IE
  • Ye, H
  • Heetveld, S
  • Lechler, MC
  • Michels, H
  • Seinstra, RI
  • Lubbe, SJ
  • Drouet, V
  • Lesage, S
  • Majounie, E
  • Gibbs, JR
  • Nalls, MA
  • Ryten, M
  • Botia, JA
  • Vandrovcova, J
  • Simon-Sanchez, J
  • Castillo-Lizardo, M
  • Rizzu, P
  • Blauwendraat, C
  • Chouhan, AK
  • Li, Y
  • Yogi, P
  • Amin, N
  • van Duijn, CM
  • Morris, HR
  • Brice, A
  • Singleton, AB
  • David, DC
  • Nollen, EA
  • Jain, S
  • Shulman, JM
  • Heutink, P
  • Hernandez, DG
  • Arepalli, S
  • Brooks, J
  • Price, R
  • Nicolas, A
  • Chong, S
  • Cookson, MR
  • Dillman, A
  • Moore, M
  • Traynor, BJ
  • Singleton, AB
  • Plagnol, V
  • Nicholas, WW
  • Sheerin, UM
  • Jose, MB
  • Charlesworth, G
  • Gardner, M
  • Guerreiro, R
  • Trabzuni, D
  • Hardy, J
  • Sharma, M
  • Saad, M
  • Javier, S-S
  • Schulte, C
  • Corvol, JC
  • Dürr, A
  • Vidailhet, M
  • Sveinbjörnsdóttir, S
  • Barker, R
  • Caroline, HW-G
  • Ben-Shlomo, Y
  • Berendse, HW
  • van Dijk, KD
  • Berg, D
  • Brockmann, K
  • Wurster, I
  • Mätzler, W
  • Gasser, T
  • Martinez, M
  • de Bie, RMA
  • Biffi, A
  • Velseboer, D
Copyright, Publisher and Additional Information: © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Parkinson’s disease; Genomics; Whole-exome sequencing; Loss-of-function; Rare variants; Functional screening; Mitochondria; Parkin; α-synuclein; Animal model
Dates:
  • Published: 30 January 2017
  • Accepted: 3 January 2017
  • Published (online): 30 January 2017
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 16 Feb 2017 16:07
Last Modified: 16 Feb 2017 16:07
Published Version: http://doi.org/10.1186/s13059-017-1147-9
Status: Published
Publisher: BioMed Central
Refereed: Yes
Identification Number: https://doi.org/10.1186/s13059-017-1147-9

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