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Deriving preference-based single indices from non-preference based condition-specific instruments: Converting AQLQ into EQ5D indices

Tsuchiya, A., Brazier, J., McColl, E. and Parkin, D. (2002) Deriving preference-based single indices from non-preference based condition-specific instruments: Converting AQLQ into EQ5D indices. Discussion Paper. (Unpublished)

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Abstract

Suppose that one has a clinical dataset with only non-preference-based QOL data, and that one nevertheless would like to perform a cost/QALY analysis. This study reports on some efforts to establish a "mapping" relationship between AQLQ (a non-preference-based QOL instrument for asthma) and EQ5D (a preference-based generic instrument). Various methods are described in terms of associated assumptions regarding the measurement properties of the instruments. This is followed by empirical mapping, based on regressing EQ5D on AQLQ. Six main regression models and two supplementary models are identified, and the regressions carried out. Performance of each model is explored in terms of goodness of fit between observed and predicted values, and of robustness of predictions on external data. The results show that it is possible to predict mean EQ5D indices given AQLQ data. The general implications for methods of mapping non-preference-based instruments onto preference-based measures are discussed.

Item Type: Monograph (Discussion Paper)
Keywords: EQ5D, AQLQ, mapping
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > Health Economics and Decision Science > HEDS Discussion Paper Series
Depositing User: ScHARR / HEDS (Sheffield)
Date Deposited: 23 Jun 2010 14:14
Last Modified: 08 Feb 2013 17:00
Status: Unpublished
Identification Number: HEDS Discussion Paper 02/01
URI: http://eprints.whiterose.ac.uk/id/eprint/10952

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