ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells.

Alagoz, M., Chiang, S. C., Sharma, A. et al. (1 more author) (2013) ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells. PLoS One, 8 (4). e58239. ISSN 1932-6203

Abstract

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Authors/Creators:
Copyright, Publisher and Additional Information: © 2013 Alagoz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Astrocytes; Ataxia Telangiectasia Mutated Proteins; Biological Assay; Camptothecin; Cell Line; DNA Breaks, Single-Stranded; DNA Topoisomerases, Type I; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Humans; Morpholines; Oxidative Stress; Phosphoric Diester Hydrolases; Pyrones; Signal Transduction; Topoisomerase I Inhibitors; Transcription, Genetic
Dates:
  • Published: 23 April 2013
  • Accepted: 1 February 2013
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biological Sciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 05 Dec 2016 16:25
Last Modified: 05 Dec 2016 16:31
Published Version: http://dx.doi.org/10.1371/journal.pone.0058239
Status: Published
Publisher: Public Library of Science
Refereed: Yes
Identification Number: https://doi.org/10.1371/journal.pone.0058239
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