TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy

Alagoz, M., Wells, O. S. and El-Khamisy, S. F. orcid.org/0000-0003-2721-7763 (2014) TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. Nucleic Acids Research, 42 (5). pp. 3089-3103. ISSN 0305-1048

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Copyright, Publisher and Additional Information: © The Author(s) 2013. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: alkylating agents; hypersensitivity; antineoplastic agents; glioblastoma; alkylation; dna; dna topoisomerases; type i; immunoblotting; poly(adp-ribose) polymerases; phosphoric diester hydrolase; poisons; precipitating factors; endonuclease; temozolomide; cancer therapy; ataxias; hereditary; cytotoxicity; tumor cells; malignant
Dates:
  • Published: March 2014
  • Published (online): 12 December 2013
  • Accepted: 12 November 2013
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biological Sciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 07 Dec 2016 15:18
Last Modified: 25 Oct 2018 06:52
Published Version: http://dx.doi.org/10.1093/nar/gkt1260
Status: Published
Publisher: Oxford University Press (OUP): Policy C - Option B
Refereed: Yes
Identification Number: https://doi.org/10.1093/nar/gkt1260
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