Wailoo, A. orcid.org/0000-0002-9324-1617, Sutton, A. and Morgan, A. (2009) The risk of febrile neutropenia in patients with non-small-cell lung cancer treated with docetaxel: a systematic review and meta-analysis. British Journal of Cancer, 100 (3). pp. 436-441. ISSN 0007-0920
Abstract
We aimed to assess the incidence of febrile neutropenia in patients with non small cell lung cancer treated with docetaxel as second line chemotherapy by systematic review and meta-analysis of clinical studies. Published studies were retrieved and included if they considered docetaxel at the licensed dose after a previous chemotherapy regimen, and reported the proportion of patients getting FN. Meta-analysis was conducted to estimate the proportion of patients who experience one or more episodes of FN. The pooled, random effects meta-analysis estimate for the proportion of patients who experience one or more episodes of FN on docetaxel was 5.95% (95% CI 4.22–8.31) based on 13 studies, comprising 1609 patients. No significant differences were seen either between studies that permitted the use of prophylactic granulocyte colony-stimulating factors or between phase II and phase III trials.
Evidence from randomised controlled trials suggests that the incidence of FN with docetaxel is around 6% and therefore an important factor to consider in the choice of the chemotherapy regimen.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2009 Cancer Research UK. Reproduced in accordance with the publisher's self-archiving policy. |
Keywords: | febrile neutropenia; docetaxel; meta-analysis; systematic review; randomized phase-III; 2nd-line therapy; clinical-trial; chemotherapy; regimens |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 28 Nov 2016 16:25 |
Last Modified: | 28 Nov 2016 16:27 |
Published Version: | http://dx.doi.org/10.1038/sj.bjc.6604863 |
Status: | Published |
Publisher: | Cancer Research UK |
Refereed: | Yes |
Identification Number: | 10.1038/sj.bjc.6604863 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:108362 |