Bourke, L., Kirkbride, P., Hooper, R. et al. (3 more authors) (2013) Endocrine therapy in prostate cancer: time for reappraisal of risks, benefits and cost-effectiveness? British Journal of Cancer, 108 (1). pp. 9-13. ISSN 0007-0920
Abstract
In the 70 years following the first description of the benefits of surgical castration, despite advances in medical therapy e.g. cabazitaxel, enzalutamide, abiraterone, androgen deprivation therapy (ADT) remains the cornerstone of treatment for advanced prostate cancer. However, with increasing numbers of men undergoing PSA testing, the disease is being diagnosed earlier and the costs of ADT, with uncertain survival benefits and associated risks, have risen dramatically. Clinical studies of potent novel agents have shown survival benefits in advanced disease, but timing, risks and cost-effectiveness of treatment remain controversial. As new agents enter clinical practice, a comprehensive research strategy is essential to optimise benefits whilst minimising harm.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2013 Cancer Research UK. Article made available via (http://creativecommons.org/licenses/by-nc-sa/4.0) |
Keywords: | prostate cancer; androgen deprivation; cost-effectiveness; cardiovascular risk |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 09 Dec 2016 11:21 |
Last Modified: | 09 Dec 2016 11:21 |
Published Version: | https://doi.org/10.1038/bjc.2012.523 |
Status: | Published |
Publisher: | Cancer Research UK |
Refereed: | Yes |
Identification Number: | 10.1038/bjc.2012.523 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107753 |
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Licence: CC-BY-NC-SA 4.0