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Can high-frequency ultrasound predict metastatic lymph nodes in patients with invasive breast cancer?

Clough, G.R., Truscott, J. and Haigh, L.I.G. (2004) Can high-frequency ultrasound predict metastatic lymph nodes in patients with invasive breast cancer? Breast Cancer Research, 6 (Suppl ). p. 18. ISSN 1465-542X

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Abstract

Aim

To determine whether high-frequency ultrasound can predict the presence of metastatic axillary lymph nodes, with a high specificity and positive predictive value, in patients with invasive breast cancer. The clinical aim is to identify patients with axillary disease requiring surgery who would not normally, on clinical grounds, have an axillary dissection, so potentially improving outcome and survival rates.

Materials and methods

The ipsilateral and contralateral axillae of 42 consecutive patients with invasive breast cancer were scanned prior to treatment using a B-mode frequency of 13 MHz and a Power Doppler frequency of 7 MHz. The presence or absence of an echogenic centre for each lymph node detected was recorded, and measurements were also taken to determine the L/S ratio and the widest and narrowest part of the cortex. Power Doppler was also used to determine vascularity. The contralateral axilla was used as a control for each patient.

Results

In this study of patients with invasive breast cancer, ipsilateral lymph nodes with a cortical bulge ≥3 mm and/or at least two lymph nodes with absent echogenic centres indicated the presence of metastatic axillary lymph nodes (10 patients). The sensitivity and specificity were 52.6% and 100%, respectively, positive and negative predictive values were 100% and 71.9%, respectively, the P value was 0.001 and the Kappa score was 0.55.

Conclusion

This would indicate that high-frequency ultrasound can be used to accurately predict metastatic lymph nodes in a proportion of patients with invasive breast cancer, which may alter patient management.

Item Type: Article
Copyright, Publisher and Additional Information: © 2004 BioMed Central Ltd.
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Academic Unit of Medical Physics (Leeds)
Depositing User: Repository Officer
Date Deposited: 13 Mar 2006
Last Modified: 05 Jun 2014 10:48
Published Version: http://breast-cancer-research.com/content/6/S1/P18
Status: Published
Refereed: Yes
Identification Number: 10.1186/bcr837
URI: http://eprints.whiterose.ac.uk/id/eprint/1045

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