Physical role for the nucleus in cell migration

Abstract

Cell migration is important for the function of many eukaryotic cells. Recently the nucleus has been shown to play an important role in cell motility. After giving an overview of cell motility mechanisms we review what is currently known about the mechanical properties of the nucleus and the connections between it and the cytoskeleton. We also discuss connections to the extracellular matrix and mechanotransduction. We identify key physical roles of the nucleus in cell migration.

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Item Type:	Article
Authors/Creators:	Fruleux, A. Hawkins, R.J.
Copyright, Publisher and Additional Information:	© 2016 IOP Publishing Ltd. Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence (//creativecommons.org/licenses/by/3.0/). Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
Keywords:	nucleus; cell migration; mechanics
Dates:	Published: 13 July 2016 Published (online): 13 July 2016 Accepted: 19 May 2016
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Science (Sheffield) > Department of Physics and Astronomy (Sheffield)
Funding Information:	Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) EP/L026848/1
Depositing User:	Symplectic Sheffield
Date Deposited:	24 Aug 2016 10:39
Last Modified:	24 Aug 2016 10:39
Published Version:	http://dx.doi.org/10.1088/0953-8984/28/36/363002
Status:	Published
Publisher:	IOP Publishing
Refereed:	Yes
Identification Number:	10.1088/0953-8984/28/36/363002
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:104034

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Physical role for the nucleus in cell migration

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