Salazar, M., Lorente, M., García-Taboada, E. et al. (19 more authors) (2015) TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling. Molecular & Cellular Oncology, 2 (3). e980134. ISSN 2372-3556
Abstract
In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC© Elizabeth Alli and James M Ford. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
Keywords: | PTEN; Tribbles pseudokinases; animal models of cancer; prostate cancer; skin carcinogenesis |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 13 Sep 2016 15:03 |
Last Modified: | 13 Sep 2016 15:08 |
Published Version: | http://dx.doi.org/10.4161/23723556.2014.980134 |
Status: | Published |
Publisher: | Taylor & Francis |
Refereed: | Yes |
Identification Number: | 10.4161/23723556.2014.980134 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:102794 |
Download
Filename: TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling.pdf
Licence: CC-BY-NC 3.0