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On the design and simulation of an airlift loop bioreactor with microbubble generation by fluidic oscillation

Zimmerman, W.B., Hewakandamby, B.N., Tesar, V., Bandulasena, H.C.H. and Omotowa, O.A. (2009) On the design and simulation of an airlift loop bioreactor with microbubble generation by fluidic oscillation. Food and Bioproducts Processing, 87 (C3). pp. 215-227. ISSN 0960-3085

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Microbubble generation by a novel fluidic oscillator driven approach is analyzed, with a view to identifying the key design elements and their differences from standard approaches to airlift loop bioreactor design. The microbubble generation mechanism has been shown to achieve high mass transfer rates by the decrease of the bubble diameter, by hydrodynamic stabilization that avoids coalescence increasing the bubble diameter, and by longer residence times offsetting slower convection. The fluidic oscillator approach also decreases the friction losses in pipe networks and in nozzles/diffusers due to boundary layer disruption, so there is actually an energetic consumption savings in using this approach over steady flow. These dual advantages make the microbubble generation approach a promising component of a novel airlift loop bioreactor whose design is presented here. The equipment, control system for flow and temperature, and the optimization of the nozzle bank for the gas distribution system are presented. (C) 2009 The Institution of Chemical Engineers. Published by Elsevier B.V All rights reserved.

Item Type: Article
Copyright, Publisher and Additional Information: © 2009 Institute of Chemical Engineers. This is an author produced version of a paper subsequently published in Food and Bioproduct Processing. Uploaded in accordance with the publisher's self-archiving policy.
Keywords: Airlift loop bioreactor; Microbubble generation; Fluidic oscillators; Transport phenomena; Biorefineries
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield)
Depositing User: Miss Anthea Tucker
Date Deposited: 03 Dec 2009 10:46
Last Modified: 16 Dec 2015 10:45
Published Version: http://dx.doi.org/10.1016/j.fbp.2009.03.006
Status: Published
Publisher: Institution of Chemical Engineers
Refereed: Yes
Identification Number: 10.1016/j.fbp.2009.03.006
URI: http://eprints.whiterose.ac.uk/id/eprint/10228

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