Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

Palles, C, Cazier, J-B, Howarth, KM et al. (36 more authors) (2013) Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. Nature Genetics, 45 (2). pp. 136-144. ISSN 1061-4036

Abstract

Metadata

Authors/Creators:
  • Palles, C
  • Cazier, J-B
  • Howarth, KM
  • Domingo, E
  • Jones, AM
  • Broderick, P
  • Kemp, Z
  • Spain, SL
  • Guarino, E
  • Salguero, I
  • Sherborne, A
  • Chubb, D
  • Carvajal-Carmona, LG
  • Ma, Y
  • Kaur, K
  • Dobbins, S
  • Barclay, E
  • Gorman, M
  • Martin, L
  • Kovac, MB
  • Humphray, S
  • The CORGI Consortium,
  • The WGS500 Consortium,
  • Lucassen, A
  • Holmes, CH
  • Bentley, D
  • Donnelly, P
  • Taylor, J
  • Petridis, C
  • Roylance, R
  • Sawyer, EJ
  • Kerr, DJ
  • Clark, S
  • Grimes, J
  • Kearsey, SE
  • Thomas, HJW
  • McVean, G
  • Houlston, RS
  • Tomlinson, I
Copyright, Publisher and Additional Information: © 2013 Nature America, Inc. This is an author produced version of a paper published in Nature Genetics. Uploaded in accordance with the publisher's self-archiving policy.
Keywords: Colorectal cancer; Genetic predisposition to disease; Mutation
Dates:
  • Published: February 2013
  • Accepted: 28 November 2012
  • Published (online): 23 December 2012
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Epidemiology and Biostatistics (Leeds)
Depositing User: Symplectic Publications
Date Deposited: 22 Aug 2016 14:32
Last Modified: 22 Aug 2016 14:32
Published Version: http://dx.doi.org/10.1038/ng.2503
Status: Published
Publisher: Nature Publishing Group
Identification Number: https://doi.org/10.1038/ng.2503

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