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Regulatory RNAs: Have mRNA Untranslated Regions Joined the Party?

Hughes, T.A. and Jones, P.F. (2008) Regulatory RNAs: Have mRNA Untranslated Regions Joined the Party? PLoS Medicine, 5 (5). e110. ISSN 1549-1277


In the last decade or so, we have become familiar with the discovery of new classes of nuclear-encoded regulators (see Glossary) as fundamental controllers of gene expression. Each new discovery has again highlighted the incomplete nature of our understanding of the genome and its regulation. First, small interfering RNAs (siRNAs) demonstrated that RNA molecules are not merely components of the cellular machinery (such as tRNAs and rRNAs) or gene-expression intermediates (mRNAs), but can function as potent trans-acting regulators of specific genes. MicroRNAs (miRNAs) continued this theme and now attract much attention among basic scientists and clinicians alike, both as potential regulators of most human genes and as potential diagnostic tools. In this issue of PLoS Medicine, a research article by Shigetada Teshima-Kondo and colleagues supports the suggestion that another class of regulatory RNAs exists [1]. Furthermore, this class could be the largest to date, since potential members are contained within every mRNA.

Item Type: Article
Copyright, Publisher and Additional Information: © 2008 Hughes and Jones. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds)
Depositing User: Sherpa Assistant
Date Deposited: 06 Nov 2009 12:51
Last Modified: 17 Aug 2015 13:36
Published Version: http://dx.doi.org/10.1371/journal.pmed.0050110
Status: Published
Publisher: Public Library of Science
Identification Number: 10.1371/journal.pmed.0050110
URI: http://eprints.whiterose.ac.uk/id/eprint/10100

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