Law, M, Bishop, DT orcid.org/0000-0002-8752-8785, Lee, JE et al. (78 more authors) (2015) Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nature Genetics, 47 (9). pp. 987-995. ISSN 1061-4036
Abstract
Thirteen common susceptibility local have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international two-stage meta-analysis of 11 genome-wide association studies (GWAS, five unpublished) of CMM and Stage two datasets, totalling 15,990 cases and 26,409 controls. Five loci not previously associated with SMM risk reached genome-wide significance (P < 5×10–8) as did two previously-reported but un-replicated loci and all thirteen established loci. Novel SNPs fall within putative melanocyte regulatory elements, and bioinformatic and eQTL data highlight candidate genes including one involved in telomere biology.
Metadata
| Item Type: | Article |
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| Authors/Creators: |
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| Copyright, Publisher and Additional Information: | © 2015, Author(s). This is an author produced version of a paper published in Nature Genetics. Uploaded in accordance with the publisher's self-archiving policy. |
| Dates: |
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| Institution: | The University of Leeds |
| Funding Information: | Funder Grant number Cancer Research UK C588/A10589 National Institute of Health - NIH (PHS) 24891-03-314 National Institute of Health - NIH (PHS) 10-17751-99-01-G5 |
| Depositing User: | Symplectic Publications |
| Date Deposited: | 15 Jan 2016 15:52 |
| Last Modified: | 15 Jul 2020 12:16 |
| Published Version: | http://dx.doi.org/10.1038/ng.3373 |
| Status: | Published |
| Publisher: | Nature Publishing Group |
| Identification Number: | 10.1038/ng.3373 |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:88170 |

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