Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism

This is the latest version of this eprint.

Pettit, L.J., Browne, H.P., Yu, L. et al. (10 more authors) (2014) Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism. BMC Genomics, 15. 160. 160 - 160. ISSN 0094-8276



  • Pettit, L.J.
  • Browne, H.P.
  • Yu, L.
  • Smits, W.K.
  • Fagan, R.P.
  • Barquist, L.
  • Martin, M.J.
  • Goulding, D.
  • Duncan, S.H.
  • Flint, H.J.
  • Dougan, G.
  • Choudhary, J.S.
  • Lawley, T.D.
Copyright, Publisher and Additional Information: © 2014 Pettit et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Keywords: Clostridium difficile; Spo0A; RNAseq; Proteomics; Sporulation; Virulence; Metabolism; Butyrate; Transmission; Genome annotation
  • Published: February 2014
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 02 Mar 2015 10:22
Last Modified: 23 Mar 2018 22:10
Published Version:
Status: Published
Publisher: BioMed Central
Refereed: Yes
Identification Number:

Available Versions of this Item


Filename: 1471-2164-15-160-s1.pdf

Description: Identification of differentially expressed genes in C. difficile 630∆erm spo0A mutant by transcriptional profiling.

Filename: 1471-2164-15-160-s2.xlsx

Description: Table summarizing genes differentially expressed in a C. difficile spo0A mutant relative to the parental strain based on transcriptomics and proteomics.

Filename: 1471-2164-15-160-s3.docx

Description: Table summarizing gene regulation genes that are controlled by C. difficile Spo0A.