β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes

Jakhria, T, Hellewell, AL, Porter, MY et al. (5 more authors) (2014) β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes. Journal of Biological Chemistry, 289 (52). 35781 - 35794. ISSN 0021-9258

Abstract

Metadata

Authors/Creators:
  • Jakhria, T
  • Hellewell, AL
  • Porter, MY
  • Jackson, MP
  • Tipping, KW
  • Xue, WF
  • Radford, SE
  • Hewitt, EW
Copyright, Publisher and Additional Information: (c) 2014, Jakhria, T, Hellewell, AL, Porter, MY, Jackson, MP, Tipping, KW, Xue, WF, Radford, SE and Hewitt, EW. This is an Open Access article distributed in accordance with the Creative Commons Attribution (CC BY 3.0) licence, which permits others to distribute, remix, adapt, build upon this work, and license their derivative works on different terms, provided the original work is properly cited.
Keywords: Amyloid; fibril; lysosome; membrane trafficking; protein degradation
Dates:
  • Published: 26 December 2014
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > NIHR Clinical Research Network Coordinating Centre (Leeds)
Depositing User: Symplectic Publications
Date Deposited: 19 Feb 2015 12:42
Last Modified: 22 Apr 2015 14:46
Published Version: http://dx.doi.org/10.1074/jbc.M114.586222
Status: Published
Publisher: American Society for Biochemistry and Molecular Biology Inc.
Identification Number: https://doi.org/10.1074/jbc.M114.586222

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