Keating, C., Ewart, L., Grundy, L. et al. (2 more authors) (2014) Translational potential of a mouse in vitro bioassay in predicting gastrointestinal adverse drug reactions in Phase I clinical trials. Neurogastroenterology and Motility, 26 (7). 980 - 989.
Abstract
Motility-related gastrointestinal (GI) adverse drug reactions (GADRs) such as diarrhea and constipation are a common and deleterious feature associated with drug development. Novel biomarkers of GI function are therefore required to aid decision making on the GI liability of compounds in development.
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Copyright, Publisher and Additional Information: | © 2014 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ||||
Keywords: | adverse drug reaction; bioassay; biomarker; gastrointestinal motility; safety pharmacology | ||||
Dates: |
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Institution: | The University of Sheffield | ||||
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) | ||||
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Depositing User: | Symplectic Sheffield | ||||
Date Deposited: | 16 Sep 2014 13:12 | ||||
Last Modified: | 16 Sep 2014 13:12 | ||||
Published Version: | http://dx.doi.org/10.1111/nmo.12349 | ||||
Status: | Published | ||||
Publisher: | Wiley | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1111/nmo.12349 | ||||
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