Maier, E.C., Saxena, A., Alsina, B. et al. (2 more authors) (2014) Sensational placodes: Neurogenesis in the otic and olfactory systems. Developmental Biology, 389. pp. 50-67. ISSN 0012-1606
Abstract
For both the intricate morphogenetic layout of the sensory cells in the ear and the elegantly radial arrangement of the sensory neurons in the nose, numerous signaling molecules and genetic determinants are required in concert to generate these specialized neuronal populations that help connect us to our environment. In this review, we outline many of the proteins and pathways that play essential roles in the differentiation of otic and olfactory neurons and their integration into their non-neuronal support structures. In both cases, well-known signaling pathways together with region-specific factors transform thickened ectodermal placodes into complex sense organs containing numerous, diverse neuronal subtypes. Olfactory and otic placodes, in combination with migratory neural crest stem cells, generate highly specialized subtypes of neuronal cells that sense sound, position and movement in space, odors and pheromones throughout our lives.
Metadata
Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 The Authors. Published by Elsevier Inc. Open access under CC BY license. |
Keywords: | Otic; Olfactory; Neurogenesis; Hair cell; Sensory neuron |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 10 Apr 2018 14:35 |
Last Modified: | 23 Jun 2023 21:38 |
Published Version: | https://doi.org/10.1016/j.ydbio.2014.01.023 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | https://doi.org/10.1016/j.ydbio.2014.01.023 |