Ageing-associated changes in transcriptional elongation influence longevity

Debès, C., Papadakis, A., Grönke, S. et al. (23 more authors) (2023) Ageing-associated changes in transcriptional elongation influence longevity. Nature, 616 (7958). pp. 814-821. ISSN 0028-0836



Copyright, Publisher and Additional Information: © 2023 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Animals; Humans; Mice; Rats; Aging; Insulin; Longevity; RNA Polymerase II; Signal Transduction; Transcription Elongation, Genetic; Drosophila melanogaster; Caenorhabditis elegans; RNA, Circular; Somatomedins; Nucleosomes; Histones; Cell Division; Caloric Restriction
  • Accepted: 7 March 2023
  • Published (online): 12 April 2023
  • Published: 27 April 2023
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 07 Jun 2023 08:18
Last Modified: 07 Jun 2023 08:18
Status: Published
Publisher: Springer Science and Business Media LLC
Refereed: Yes
Identification Number:
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