Gene of the month: NKX3.1

Abstract

NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer, NKX3.1 activity is frequently reduced through a combination of mutational and post-translational events. Owing to its specificity for prostate tissue, NKX3.1 has found use as an immunohistochemical marker in routine histopathology practice.

Metadata

Authors/Creators:

Griffin, J. https://orcid.org/0000-0003-3969-7637
Chen, Y.
Catto, J.W.F. https://orcid.org/0000-0003-2787-8828
El-Khamisy, S. https://orcid.org/0000-0003-2721-7763

© Author(s) (or their employer(s)) 2022. This is an author-produced version of a paper subsequently published in Journal of Clinical Pathology. Uploaded in accordance with the publisher's self-archiving policy. No commercial re-use.

Dates: