Synthetic biology approaches to actinomycete strain improvement

Abstract

Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains.

Metadata

Authors/Creators:

Breitling, Rainer
Avbelj, Martina
Bilyk, Oksana
Carratore, Francesco Del
Filisetti, Alessandro
Hanko, Erik K.R.
Iorio, Marianna
Redondo, Rosario Pérez
Reyes, Fernando
Rudden, Michelle https://orcid.org/0000-0001-9617-087X
Severi, Emmanuele (es513@york.ac.uk)
Slemc, Lucija
Schmidt, Kamila
Whittall, Dominic R.
Donadio, Stefano
García, Antonio Rodríguez
Genilloud, Olga
Kosec, Gregor
De Lucrezia, Davide
Petković, Hrvoje
Thomas, Gavin https://orcid.org/0000-0002-9763-1313
Takano, Eriko

Funding Information: This review was funded through the European Union s Horizon 2020 Research and Innovation Programme under grant agreement number 720793 TOPCAPI Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of FEMS.

Keywords:

Actinobacteria, Actinomycete, Biosynthesis, Biotechnology, Synthetic biology

Dates: