Keane, P.M., Baptista, F.R., Gurung, S.P. et al. (7 more authors) (2016) Long-lived excited-state dynamics of i-motif structures probed by time-resolved infrared spectroscopy. ChemPhysChem, 17 (9). pp. 1281-1287. ISSN 1439-4235
Abstract
UV-generated excited states of cytosine (C) nucleobases are precursors to mutagenic photoproduct formation. The i-motif formed from C-rich sequences is known to exhibit high yields of long-lived excited states following UV absorption. Here the excited states of several i-motif structures have been characterized following 267 nm laser excitation using time-resolved infrared spectroscopy (TRIR). All structures possess a long-lived excited state of ∼300 ps and notably in some cases decays greater than 1 ns are observed. These unusually long-lived lifetimes are attributed to the interdigitated DNA structure which prevents direct base stacking overlap.
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Copyright, Publisher and Additional Information: | © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of a paper subsequently published in ChemPhysChem. Uploaded in accordance with the publisher's self-archiving policy. | ||||
Keywords: | cytosine; DNA; excited states; i-motifs; time-resolved infrared spectroscopy | ||||
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Institution: | The University of Sheffield | ||||
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research | ||||
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Depositing User: | Symplectic Sheffield | ||||
Date Deposited: | 11 May 2022 13:46 | ||||
Last Modified: | 13 May 2022 03:57 | ||||
Status: | Published | ||||
Publisher: | Wiley | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1002/cphc.201501183 | ||||
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