An ex vivo perfused ventilated murine lung model suggests lack of acute pulmonary toxicity of the potential novel anticancer agent (−)-englerin A

Schremmer, C, Steinritz, D, Gudermann, T et al. (2 more authors) (2022) An ex vivo perfused ventilated murine lung model suggests lack of acute pulmonary toxicity of the potential novel anticancer agent (−)-englerin A. Archives of Toxicology, 96 (4). pp. 1055-1063. ISSN 0340-5761

Abstract

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Copyright, Publisher and Additional Information: © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Anti-cancer drug; Lung edema; Classical transient receptor potential 4 and 5 (TRPC4, TRPC5); Tidal volume; Wet-to-dry weight ratio; FITC–dextran permeation assay
Dates:
  • Accepted: 20 January 2022
  • Published (online): 14 February 2022
  • Published: April 2022
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds)
Funding Information:
FunderGrant number
MRC (Medical Research Council) ExceptionP.O. 4050781788
Depositing User: Symplectic Publications
Date Deposited: 22 Feb 2022 16:48
Last Modified: 17 Jun 2022 01:13
Status: Published
Publisher: Springer
Identification Number: https://doi.org/10.1007/s00204-022-03235-z
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