Kalaoglu-Altan, O.I., Baskan, H., Meireman, T. et al. (9 more authors) (2021) Silver nanoparticle-coated polyhydroxyalkanoate based electrospun fibers for wound dressing applications. Materials, 14 (17). 4907. ISSN 1996-1944
Abstract
Wound dressings are high performance and high value products which can improve the regeneration of damaged skin. In these products, bioresorption and biocompatibility play a key role. The aim of this study is to provide progress in this area via nanofabrication and antimicrobial natural materials. Polyhydroxyalkanoates (PHAs) are a bio-based family of polymers that possess high biocompatibility and skin regenerative properties. In this study, a blend of poly(3-hydroxybutyrate) (P(3HB)) and poly(3-hydroxyoctanoate-co-3-hydroxy decanoate) (P(3HO-co-3HD)) was electrospun into P(3HB))/P(3HO-co-3HD) nanofibers to obtain materials with a high surface area and good handling performance. The nanofibers were then modified with silver nanoparticles (AgNPs) via the dip-coating method. The silver-containing nanofiber meshes showed good cytocompatibility and interesting immunomodulatory properties in vitro, together with the capability of stimulating the human beta defensin 2 and cytokeratin expression in human keratinocytes (HaCaT cells), which makes them promising materials for wound dressing applications.
Metadata
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Copyright, Publisher and Additional Information: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | ||||
Keywords: | polyhydroxyalkanoates; eco-friendly nanofibers; wound dressings; low-impact biomedical applications; immunomodulation; defensin; keratinocytes | ||||
Dates: |
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Institution: | The University of Sheffield | ||||
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Materials Science and Engineering (Sheffield) | ||||
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Depositing User: | Symplectic Sheffield | ||||
Date Deposited: | 06 Sep 2021 14:43 | ||||
Last Modified: | 07 Sep 2021 09:11 | ||||
Status: | Published | ||||
Publisher: | MDPI AG | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.3390/ma14174907 |