Self-Assembled Supramolecular Hybrid Hydrogel Beads Loaded with Silver Nanoparticles for Antimicrobial Application

Abstract

This paper reports the formation of silver (Ag) NPs within spatially-resolved two-component hydrogel beads that combine a low-molecular-weight gelator (LMWG) DBS-CONHNH2 and a polymer gelator (PG) calcium alginate. The AgNPs are formed via in situ reduction of Ag(I), with the resulting nanoparticle-loaded gels being characterised in detail. We tested the antibacterial activity of the nanocomposite gel beads against two drug-resistant bacterial strains, often associated with hospital-acquired infections: vancomycin-resistant Enterococcus faecium (VRE) and Pseudomonas aeruginosa (PA14), and the AgNP-loaded gels showed good antimicrobial properties against both types of bacteria. We suggest that the gel bead format of these AgNP-loaded hybrid hydrogels makes them promising versatile materials for potential applications in orthopaedics or wound healing.

Metadata

Authors/Creators:

Piras, Carmen Cristina https://orcid.org/0000-0002-7128-2979
Mahon, Clare Sarah (csm543@york.ac.uk)
Smith, David Kelham https://orcid.org/0000-0002-9881-2714

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Dates: