Newton, R, Waszkowycz, B, Seewooruthun, C et al. (14 more authors) (2020) Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase. ACS Medicinal Chemistry Letters. acsmedchemlett.9b00615. ISSN 1948-5875
Abstract
A combination of focused library and virtual screening, hit expansion, and rational design has resulted in the development of a series of inhibitors of RETV804M kinase, the anticipated drug-resistant mutant of RET kinase. These agents do not inhibit the wild type (wt) isoforms of RET or KDR and therefore offer a potential adjunct to RET inhibitors currently undergoing clinical evaluation.
Metadata
Authors/Creators: |
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Copyright, Publisher and Additional Information: | Copyright © 2020 American Chemical Society. This is an author produced version of a paper published in ACS Medicinal Chemistry Letters. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 Apr 2020 08:59 |
Last Modified: | 06 Mar 2021 01:38 |
Status: | Published online |
Publisher: | American Chemical Society (ACS) |
Identification Number: | https://doi.org/10.1021/acsmedchemlett.9b00615 |