Cover Feature: Recognition of ASF1 by Using Hydrocarbon‐Constrained Peptides (ChemBioChem 7/2019)

The cover feature picture shows how inhibition of the histone H3‐ASF1 (anti‐silencing function 1) protein–protein interaction (PPI) represents a potential approach for the treatment of numerous cancers. To pursue this goal, a hydrocarbon constraint was used to pre‐organize the histone H3 peptide in α‐helical conformation; despite conferring protection against proteolysis, this constrained peptide unexpectedly exhibited enthalpy–entropy compensation in comparison to the natural sequence, in its binding of ASF1. More information can be found in the communication by F. Ochsenbein, A. J. Wilson et al. on page 891 in Issue 7, 2019 (DOI: 10.1002/cbic.201800633).