%PDF-1.3
%
28 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
7 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
25 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
19 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
22 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
24 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
14 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
4 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
9 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
18 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
21 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
11 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
8 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
37 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
17 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
36 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
12 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
35 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
29 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
31 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
40 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
3 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 141>>stream
xA DbQӸ4o(4|-ռ7w̳C;#::lt
;En,[DW8yH \9 rB_ԌH+ϮR'J!hG5{rs?M1
endstream
endobj
23 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
30 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
26 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
41 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
38 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
6 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
1 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 123>>stream
xs
w3TPI2P0T5T0PT03
ri'(e&*y))+)&%g 5(Z*$(ZY+h8h)hdq "溆p ^
endstream
endobj
15 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
32 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
33 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
10 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
13 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
16 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
39 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
5 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
20 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
27 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 46>>stream
xs
w3TPI2T0 BCcC#=s#c\.
͐,.. r
endstream
endobj
34 0 obj
<>>>/BBox[0 0 625.44 818.36]/Length 47>>stream
xs
w3TPI2T0 BCcC#=s#C#\.
͐,.. %
endstream
endobj
43 0 obj
<>stream
Acrobat Distiller 8.1.0 (Windows); modified using iText 4.2.0 by 1T3XT
2019-03-28T11:32:33-04:00
Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease
10.1021/acs.jmedchem.8b01721
American Chemical Society
Giampiero Colombano
John J. Caldwell
Thomas P. Matthews
Chitra Bhatia
Amar Joshi
Tatiana McHardy
Ngai Yi Mok
Yvette Newbatt
Lisa Pickard
Jade Strover
Somaieh Hedayat
Michael I. Walton
Stephanie M. Myers
Alan M. Jones
Harry Saville
Craig McAndrew
Rosemary Burke
Suzanne A. Eccles
Faith E. Davies
Richard Bayliss
Ian Collins
application/pdf
research-article
http://pubs.acs.org/doi/suppl/10.1021/acs.jmedchem.8b01721
© 2019 American Chemical Society
American Chemical Society
True
© 2019 American Chemical Society
© 2019 American Chemical Society
Issue
10.1021/acs.jmedchem.8b01721
VoR
02/19/2019
62
5
2447
2465
© 2019 American Chemical Society
article
0022-2623
1520-4804
Journal of Medicinal Chemistry
research-article
Issue10.1021/acs.jmedchem.8b01721VoR
endstream
endobj
44 0 obj
<>stream
x+ |
endstream
endobj
45 0 obj
<>stream
xS**T0T0 Bib]" +
]
endstream
endobj
46 0 obj
<>stream
x+ |
endstream
endobj
47 0 obj
<>stream
xS**T0T0 Bih]"
c
endstream
endobj
48 0 obj
<>stream
x+ |
endstream
endobj
49 0 obj
<>stream
xS**T0T0 Bil]" W
_
endstream
endobj
50 0 obj
<>stream
x+ |
endstream
endobj
51 0 obj
<>stream
xS**T0T0 BiU"
endstream
endobj
52 0 obj
<>stream
x+ |
endstream
endobj
53 0 obj
<>stream
xS**T0T0 Bil]"
g
endstream
endobj
54 0 obj
<>stream
x+ |
endstream
endobj
55 0 obj
<>stream
xS**T0T0 BiU n)ST
endstream
endobj
56 0 obj
<>stream
x+ |
endstream
endobj
57 0 obj
<>stream
xS**T0T0 Bil]" k
k
endstream
endobj
58 0 obj
<>stream
x+ |
endstream
endobj
59 0 obj
<>stream
xS**T0T0 Bid]" '
]
endstream
endobj
60 0 obj
<>stream
x+ |
endstream
endobj
61 0 obj
<>stream
xS**T0T0 Bih]"
W
endstream
endobj
62 0 obj
<>stream
x+ |
endstream
endobj
63 0 obj
<>stream
xS**T0T0 Bih]"
g
endstream
endobj
64 0 obj
<>stream
x+ |
endstream
endobj
65 0 obj
<>stream
xS**T0T0 Bid]" ;
i
endstream
endobj
66 0 obj
<>stream
x+ |
endstream
endobj
67 0 obj
<>stream
xS**T0T0 Bil]"
c
endstream
endobj
68 0 obj
<>stream
x+ |
endstream
endobj
69 0 obj
<>stream
xS**T0T0 BiU" n
endstream
endobj
70 0 obj
<>stream
x+ |
endstream
endobj
71 0 obj
<>stream
xS**T0T0 Bih]" S
_
endstream
endobj
72 0 obj
<>stream
x+ |
endstream
endobj
73 0 obj
<>stream
xS**T0T0 Bid]"
a
endstream
endobj
74 0 obj
<>stream
x+ |
endstream
endobj
75 0 obj
<>stream
xS**T0T0 Bid]"
Y
endstream
endobj
76 0 obj
<>stream
x+ |
endstream
endobj
77 0 obj
<>stream
xS**T0T0 Bid]"
e
endstream
endobj
78 0 obj
<>stream
x+ |
endstream
endobj
79 0 obj
<>stream
xS**T0T0 Bih]"
[
endstream
endobj
80 0 obj
<>stream
x+ |
endstream
endobj
81 0 obj
<>stream
xS**T0T0 Bil]"
[
endstream
endobj
82 0 obj
<>
endobj
42 0 obj
<>stream
x][o+