Couturier, Marie, Ladevèze, Simon, Sulzenbacher, Gerlind et al. (19 more authors) (2018) Lytic xylan oxidases from wood-decay fungi unlock biomass degradation. NATURE CHEMICAL BIOLOGY. pp. 306-310. ISSN 1552-4450
Abstract
Wood biomass is the most abundant feedstock envisioned for the development of modern biorefineries. However, the cost-ef-fective conversion of this form of biomass into commodity products is limited by its resistance to enzymatic degradation. Here we describe a new family of fungal lytic polysaccharide monooxygenases (LPMOs) prevalent among white-rot and brown-rot basidiomycetes that is active on xylans—a recalcitrant polysaccharide abundant in wood biomass. Two AA14 LPMO members from the white-rot fungus Pycnoporus coccineus substantially increase the efficiency of wood saccharification through oxida-tive cleavage of highly refractory xylan-coated cellulose fibers. The discovery of this unique enzyme activity advances our knowledge on the degradation of woody biomass in nature and offers an innovative solution for improving enzyme cocktails for biorefinery applications.
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Copyright, Publisher and Additional Information: | © 2018, Springer Nature. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details | ||||||
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Institution: | The University of York | ||||||
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) | ||||||
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Depositing User: | Pure (York) | ||||||
Date Deposited: | 31 Jan 2018 16:10 | ||||||
Last Modified: | 04 Feb 2024 00:52 | ||||||
Published Version: | https://doi.org/10.1038/nchembio.2558 | ||||||
Status: | Published | ||||||
Refereed: | Yes | ||||||
Identification Number: | https://doi.org/10.1038/nchembio.2558 | ||||||
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