Murray, LJ orcid.org/0000-0003-0658-6455, Lilley, J, Hawkins, MA et al. (3 more authors) (2017) Pelvic re-irradiation using stereotactic ablative radiotherapy (SABR): A systematic review. Radiotherapy and Oncology, 125 (2). pp. 213-222. ISSN 0167-8140
Abstract
Background and purpose: To perform a systematic review regarding the use of stereotactic ablative radiotherapy (SABR) for the re-irradiation of recurrent malignant disease within the pelvis, to guide the clinical implementation of this technique. Material and methods: A systematic search strategy was adopted using the MEDLINE, EMBASE and Cochrane Library databases. Results: 195 articles were identified, of which 17 were appropriate for inclusion. Studies were small and data largely retrospective. In total, 205 patients are reported to have received pelvic SABR re-irradiation. Dose and fractionation schedules and re-irradiated volumes are highly variable. Little information is provided regarding organ at risk constraints adopted in the re-irradiation setting. Treatment appears well-tolerated overall, with nine grade 3 and six grade 4 toxicities amongst thirteen re-irradiated patients. Local control at one year ranged from 51% to 100%. Symptomatic improvements were also noted. Conclusions: For previously irradiated patients with recurrent pelvic disease, SABR re-irradiation could be a feasible intervention for those who otherwise have limited options. Evidence to support this technique is limited but shows initial promise. Based on the available literature, suggestions for a more formal SABR re-irradiation pathway are proposed. Prospective studies and a multidisciplinary approach are required to optimise future treatment.
Metadata
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Copyright, Publisher and Additional Information: | © 2017 Elsevier B.V. This is an author produced version of a paper published in Radiotherapy and Oncology. Uploaded in accordance with the publisher's self-archiving policy. | ||||
Keywords: | Stereotactic ablative radiotherapy (SABR); Re-irradiation; Pelvic tumours | ||||
Dates: |
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Institution: | The University of Leeds | ||||
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) | ||||
Funding Information: |
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Depositing User: | Symplectic Publications | ||||
Date Deposited: | 03 Nov 2017 16:24 | ||||
Last Modified: | 21 Oct 2018 00:38 | ||||
Status: | Published | ||||
Publisher: | Elsevier | ||||
Identification Number: | https://doi.org/10.1016/j.radonc.2017.09.030 |
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