Roy, Soumya S. orcid.org/0000-0002-9193-9712, Norcott, Philip orcid.org/0000-0003-4082-2079, Rayner, Peter J. orcid.org/0000-0002-6577-4117 et al. (2 more authors) (2017) A Simple Route to Strong Carbon-13 NMR Signals Detectable for Several Minutes. Chemistry : A European Journal. pp. 10496-10500. ISSN 1521-3765
Abstract
Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) suffer from low sensitivity and limited nuclear spin memory lifetimes. Although hyperpolarization techniques increase sensitivity, there is also a desire to increase relaxation times to expand the range of applications addressable by these methods. Here, we demonstrate a route to create hyperpolarized magnetization in 13C nuclear spin pairs that last much longer than normal lifetimes by storage in a singlet state. By combining molecular design and low-field storage with para-hydrogen derived hyperpolarization, we achieve more than three orders of signal amplification relative to equilibrium Zeeman polarization and an order of magnitude extension in state lifetime. These studies use a range of specifically synthesized pyridazine derivatives and dimethyl p-tolyl phenyl pyridazine is the most successful, achieving a lifetime of about 190s in low-field, which leads to a 13C-signal that is visible for 10 minutes.
Metadata
Item Type: | Article | ||||
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Wiley-VCH | ||||
Keywords: | Hyperpolarization, Long-lived singlet states, NMR spectroscopy, para-hydrogen, Structure elucidation | ||||
Dates: |
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Institution: | The University of York | ||||
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Psychology (York) |
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Funding Information: |
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Depositing User: | Pure (York) | ||||
Date Deposited: | 19 Jun 2017 15:30 | ||||
Last Modified: | 21 Mar 2024 23:29 | ||||
Published Version: | https://doi.org/10.1002/chem.201702767 | ||||
Status: | Published | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1002/chem.201702767 | ||||
Related URLs: |
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Filename: Accepted_Article.pdf
Description: Accepted Article
Filename: Roy_et_al_2017_Chemistry_A_European_Journal.pdf
Description: A Simple Route to Strong Carbon-13 NMR Signals Detectable for Several Minutes