%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Julie George, Rohini Mathur, Anoop Dinesh Shah, Mar Pujades-Rodriguez, Spiros Denaxas, Liam Smeeth, Adam Timmis, Harry Hemingway
Ethnicity and the first diagnosis of a wide range of cardiovascular diseases: Associations in a linked electronic health record cohort of 1 million patients
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 12 0 R/Contents 13 0 R/TrimBox[0 0 612 792]>>
endobj
12 0 obj
[14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R]
endobj
14 0 obj
<>/Border[0 0 0]/A 42 0 R>>
endobj
42 0 obj
<>
endobj
15 0 obj
<>/Border[0 0 0]/A 43 0 R>>
endobj
43 0 obj
<>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref002)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref003)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref004)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref005)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref006)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref007)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref008)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref009)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref010)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref011)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref007)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref012)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref013)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref009)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref014)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref015)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref007)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref011)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref016)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref024)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref025)>>
endobj
38 0 obj
<>/Border[0 0 0]/A 44 0 R>>
endobj
44 0 obj
<>
endobj
39 0 obj
<>/Border[0 0 0]/A 45 0 R>>
endobj
45 0 obj
<>
endobj
40 0 obj
<>/Border[0 0 0]/A 46 0 R>>
endobj
46 0 obj
<>
endobj
41 0 obj
<>/Border[0 0 0]/A 47 0 R>>
endobj
47 0 obj
<>
endobj
13 0 obj
[48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R]
endobj
48 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 544.0759 m
199.9998 544.0759 l
199.9998 544.576 l
575.9997 544.576 l
f*
0.83 0.64 0.02 0 k
200.0126 556.4976 m
261.1276 556.4976 l
h
f*
265.8331 556.4976 m
354.5008 556.4976 l
h
f*
566.1921 470.948 m
570.8976 470.948 l
h
f*
482.8535 457.9087 m
487.5591 457.9087 l
h
f*
342.4819 431.9433 m
347.2441 431.9433 l
h
f*
423.0425 418.9039 m
427.8047 418.9039 l
h
f*
430.0157 418.9039 m
434.778 418.9039 l
h
f*
532.6299 418.9039 m
537.3921 418.9039 l
h
f*
274.3937 405.9213 m
279.1559 405.9213 l
h
f*
281.4236 405.9213 m
286.1858 405.9213 l
h
f*
413.1213 405.9213 m
417.8835 405.9213 l
h
f*
203.4142 392.9386 m
212.9386 392.9386 l
h
f*
215.1496 392.9386 m
224.674 392.9386 l
h
f*
273.7701 379.8992 m
278.5323 379.8992 l
h
f*
280.8 379.8992 m
290.3244 379.8992 l
h
f*
292.5921 379.8992 m
302.0598 379.8992 l
h
f*
469.4173 379.8992 m
474.1228 379.8992 l
h
f*
476.3906 379.8992 m
485.915 379.8992 l
h
f*
359.7165 366.9165 m
369.2409 366.9165 l
h
f*
371.5087 366.9165 m
376.2142 366.9165 l
h
f*
378.4819 366.9165 m
388.0063 366.9165 l
h
f*
284.1449 301.9465 m
293.6693 301.9465 l
h
f*
298.8283 301.9465 m
308.3528 301.9465 l
h
f*
359.0362 184.9323 m
368.5606 184.9323 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.0125 707.7543 cm
BT
/F0 1 Tf
1 TL
0.01 Tc
0 0 Td
(arterial)Tj
3.3478 0 Td
(disease)Tj
3.7179 0 Td
(was)Tj
2.023 0 Td
(less)Tj
2.035 0 Td
(likely)Tj
2.4944 0 Td
(for)Tj
1.4144 0 Td
(Black)Tj
2.7153 0 Td
(\(0.63)Tj
2.5422 0 Td
(\(0.500.80\)\))Tj
5.7767 0 Td
(and)Tj
1.9096 0 Td
(South)Tj
2.8764 0 Td
(Asian)Tj
2.7631 0 Td
(patients)Tj
-33.6158 -1.474 Td
(\(0.70)Tj
2.5422 0 Td
(\(0.570.86\)\))Tj
5.7767 0 Td
(compared)Tj
4.7323 0 Td
(with)Tj
2.035 0 Td
(White)Tj
2.8227 0 Td
(patients.)Tj
ET
Q
q
1 j
1 J
0 w
11.4998 0 0 11.4998 200.0125 663.6472 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Discussion)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 646.6393 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(While)Tj
2.6914 0 Td
(we)Tj
1.4859 0 Td
(found)Tj
2.6914 0 Td
(the)Tj
1.5934 0 Td
(anticipated)Tj
4.9949 0 Td
(substantial)Tj
4.9412 0 Td
(predominance)Tj
6.4809 0 Td
(of)Tj
1.0443 0 Td
(coronary)Tj
4.07 0 Td
(heart)Tj
2.4706 0 Td
(disease)Tj
3.6224 0 Td
(presen-)Tj
-36.0864 -1.474 Td
(tations)Tj
3.133 0 Td
(in)Tj
0.9846 0 Td
(South)Tj
2.8048 0 Td
(Asian)Tj
2.6914 0 Td
(and)Tj
1.8679 0 Td
(predominance)Tj
6.4809 0 Td
(of)Tj
1.0443 0 Td
(stroke)Tj
2.9182 0 Td
(presentations)Tj
6.1527 0 Td
(in)Tj
0.9846 0 Td
(Black)Tj
2.6377 0 Td
(patients,)Tj
3.9626 0 Td
(we)Tj
-35.6627 -1.474 Td
(found)Tj
2.6914 0 Td
(no)Tj
1.3188 0 Td
(ethnic)Tj
2.8526 0 Td
(differences)Tj
5.0546 0 Td
(in)Tj
0.9846 0 Td
(presentation)Tj
5.6574 0 Td
(with)Tj
1.9753 0 Td
(heart)Tj
2.4765 0 Td
(failure.)Tj
3.1808 0 Td
(We)Tj
1.7127 0 Td
(consider)Tj
3.9506 0 Td
(the)Tj
1.5993 0 Td
(public)Tj
2.7929 0 Td
(health)Tj
-36.2475 -1.474 Td
(and)Tj
1.8619 0 Td
(research)Tj
4.0699 0 Td
(implications)Tj
5.3769 0 Td
(of)Tj
1.0443 0 Td
(our)Tj
1.6471 0 Td
(findings.)Tj
ET
Q
q
1 j
1 J
0 w
11.4998 0 0 11.4998 200.0125 574.5826 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Trial)Tj
2.317 0 Td
(Registration)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 557.5748 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(NCT02176174)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
6.9284 0 Td
(www.clinicaltrials)Tj
7.4596 0 Td
(.gov)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 488.9763 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 472.0251 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Cardiovascular)Tj
6.2418 0 Td
(disease)Tj
3.016 0 Td
(accounts)Tj
3.7474 0 Td
(for)Tj
1.3833 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(a)Tj
0.652 0 Td
(quarter)Tj
3.1521 0 Td
(of)Tj
1.0148 0 Td
(all)Tj
1.1508 0 Td
(deaths)Tj
2.7893 0 Td
(in)Tj
1.0375 0 Td
(England)Tj
3.5603 0 Td
(and)Tj
1.7291 0 Td
(Wales[)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(])Tj
-33.8454 -1.3039 Td
(and)Tj
1.7291 0 Td
(contributes)Tj
4.7508 0 Td
(15%)Tj
1.9332 0 Td
(of)Tj
1.0148 0 Td
(all)Tj
1.1452 0 Td
(disability)Tj
3.8494 0 Td
(adjusted)Tj
3.5773 0 Td
(life)Tj
1.4457 0 Td
(years)Tj
2.262 0 Td
(lost)Tj
1.6328 0 Td
(in)Tj
1.0374 0 Td
(England.[)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
5.1647 0 Td
(However)Tj
3.8495 0 Td
(the)Tj
1.474 0 Td
(bur-)Tj
-34.8659 -1.2982 Td
(den)Tj
1.7177 0 Td
(of)Tj
1.0148 0 Td
(cardiovascular)Tj
6.0038 0 Td
(disease)Tj
3.016 0 Td
(\(CVD\))Tj
2.9934 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(United)Tj
3.0217 0 Td
(Kingdom)Tj
4.0308 0 Td
(\(UK\))Tj
2.3074 0 Td
(varies)Tj
2.5342 0 Td
(between)Tj
3.5263 0 Td
(ethnic)Tj
-32.6719 -1.2983 Td
(groups)Tj
2.9706 0 Td
(and)Tj
1.7292 0 Td
(type)Tj
1.9105 0 Td
(of)Tj
1.0148 0 Td
(CVD)Tj
2.3187 0 Td
(diagnosis.[)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(])Tj
5.3348 0 Td
(Compared)Tj
4.4844 0 Td
(to)Tj
1.0261 0 Td
(White)Tj
2.7042 0 Td
(UK)Tj
1.6271 0 Td
(residents,)Tj
4.0309 0 Td
(South)Tj
2.5568 0 Td
(Asian)Tj
2.5115 0 Td
(resi-)Tj
-34.2196 -1.3039 Td
(dents)Tj
2.3754 0 Td
(have)Tj
2.0636 0 Td
(been)Tj
2.1203 0 Td
(found)Tj
2.6192 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(at)Tj
0.9524 0 Td
(increased)Tj
3.9968 0 Td
(risk)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(angina,[)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(])Tj
5.0003 0 Td
(myocardial)Tj
4.7055 0 Td
(infarction,[)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(])Tj
5.5558 0 Td
(coro-)Tj
-34.2989 -1.2983 Td
(nary)Tj
2.0295 0 Td
(heart)Tj
2.2734 0 Td
(disease[)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(])Tj
4.8756 0 Td
(but)Tj
1.5534 0 Td
(lower)Tj
2.4491 0 Td
(risk)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(heart)Tj
2.2733 0 Td
(failure,[)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(])Tj
4.1613 0 Td
(and)Tj
1.7291 0 Td
(out-of-hospital)Tj
6.2078 0 Td
(cardiac)Tj
3.1011 0 Td
(arrest)Tj
-33.3862 -1.2982 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(].)Tj
3.2541 0 Td
(In)Tj
1.1055 0 Td
(contrast,)Tj
3.6907 0 Td
(Black)Tj
2.3981 0 Td
(residents)Tj
3.8041 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.1203 0 Td
(found)Tj
2.6192 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(at)Tj
0.9524 0 Td
(increased)Tj
4.0025 0 Td
(risk)Tj
1.7121 0 Td
(of)Tj
1.0148 0 Td
(stroke)Tj
2.6816 0 Td
(in)Tj
1.0318 0 Td
(most)Tj
-34.6221 -1.304 Td
(but)Tj
1.5533 0 Td
(not)Tj
1.5704 0 Td
(all)Tj
1.1509 0 Td
(studies[)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(])Tj
6.4913 0 Td
(and)Tj
1.7291 0 Td
(similar)Tj
2.9877 0 Td
(or)Tj
1.0998 0 Td
(lower)Tj
2.4491 0 Td
(risk)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(heart)Tj
2.2734 0 Td
(failure[)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(])Tj
5.1137 0 Td
(and)Tj
1.7291 0 Td
(other)Tj
2.3471 0 Td
(heart)Tj
2.2733 0 Td
(dis-)Tj
-35.5008 -1.2982 Td
(eases)Tj
2.2223 0 Td
(compared)Tj
4.2406 0 Td
(to)Tj
1.0261 0 Td
(White)Tj
2.7043 0 Td
(UK)Tj
1.627 0 Td
(residents.[)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(])Tj
7.5402 0 Td
(Studies)Tj
3.101 0 Td
(are)Tj
1.4457 0 Td
(lacking)Tj
3.1011 0 Td
(on)Tj
1.2756 0 Td
(ethnic)Tj
2.7099 0 Td
(differences)Tj
4.5637 0 Td
(in)Tj
-35.5575 -1.2983 Td
(incidence)Tj
4.0705 0 Td
(of)Tj
1.0148 0 Td
(some)Tj
2.33 0 Td
(cardiovascular)Tj
6.0038 0 Td
(disease)Tj
3.0217 0 Td
(diagnoses,)Tj
4.337 0 Td
(specifically)Tj
4.5751 0 Td
(peripheral)Tj
4.3143 0 Td
(arterial)Tj
3.067 0 Td
(disease,)Tj
-32.7342 -1.3039 Td
(stroke)Tj
2.6758 0 Td
(subtypes,)Tj
3.8948 0 Td
(and)Tj
1.7291 0 Td
(abdominal)Tj
4.5128 0 Td
(aortic)Tj
2.5228 0 Td
(aneurysm.)Tj
-14.1391 -1.2983 Td
(Despite)Tj
3.2484 0 Td
(the)Tj
1.4684 0 Td
(range)Tj
2.4661 0 Td
(of)Tj
1.0148 0 Td
(studies)Tj
2.9877 0 Td
(investigating)Tj
5.3178 0 Td
(ethnic)Tj
2.7099 0 Td
(differences)Tj
4.5637 0 Td
(in)Tj
1.0375 0 Td
(incident)Tj
3.5206 0 Td
(cardiovascular)Tj
6.0037 0 Td
(dis-)Tj
-35.5348 -1.2982 Td
(eases,)Tj
2.4491 0 Td
(most)Tj
2.2053 0 Td
(previous)Tj
3.6453 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
2.0636 0 Td
(looked)Tj
2.9254 0 Td
(at)Tj
0.9524 0 Td
(individual)Tj
4.286 0 Td
(or)Tj
1.0998 0 Td
(a)Tj
0.652 0 Td
(limited)Tj
3.0727 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(cardiovascular)Tj
-30.7727 -1.2983 Td
(diseases)Tj
3.3788 0 Td
(in)Tj
1.0318 0 Td
(isolation.[)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(])Tj
6.9846 0 Td
(It)Tj
0.856 0 Td
(is)Tj
0.8504 0 Td
(unknown)Tj
4.0819 0 Td
(how)Tj
1.9388 0 Td
(UK)Tj
1.6271 0 Td
(ethnic)Tj
2.7099 0 Td
(groups)Tj
2.9707 0 Td
(differ)Tj
2.3868 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(cardiovascular)Tj
-31.3169 -1.3039 Td
(disease)Tj
3.016 0 Td
(with)Tj
1.9956 0 Td
(which)Tj
2.6532 0 Td
(they)Tj
1.9219 0 Td
(are)Tj
1.4513 0 Td
(first)Tj
1.8028 0 Td
(diagnosed)Tj
4.286 0 Td
(across)Tj
2.6759 0 Td
(a)Tj
0.6519 0 Td
(range)Tj
2.4662 0 Td
(of)Tj
1.0147 0 Td
(specific)Tj
3.1862 0 Td
(acute)Tj
2.33 0 Td
(and)Tj
1.7292 0 Td
(chronic)Tj
3.2881 0 Td
(disease)Tj
-34.469 -1.2983 Td
(diagnoses.)Tj
4.3369 0 Td
(First)Tj
2.0466 0 Td
(lifetime)Tj
3.2542 0 Td
(cardiovascular)Tj
6.0037 0 Td
(disease)Tj
3.0161 0 Td
(diagnosis)Tj
3.9571 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(turning)Tj
3.2484 0 Td
(point)Tj
2.3585 0 Td
(in)Tj
1.0374 0 Td
(a)Tj
0.652 0 Td
(patient's)Tj
3.583 0 Td
(expe-)Tj
-34.9963 -1.2982 Td
(rience,)Tj
2.9026 0 Td
(marking)Tj
3.6227 0 Td
(the)Tj
1.4683 0 Td
(end)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(possibility)Tj
4.2689 0 Td
(of)Tj
1.0148 0 Td
(primary)Tj
3.4583 0 Td
(prevention)Tj
4.5807 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
1.4683 0 Td
(beginning)Tj
4.2633 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(need)Tj
-35.4668 -1.304 Td
(to)Tj
1.0261 0 Td
(consider)Tj
3.6453 0 Td
(secondary)Tj
4.2746 0 Td
(prevention,)Tj
4.8019 0 Td
(so)Tj
1.0885 0 Td
(understanding)Tj
6.0718 0 Td
(how)Tj
1.9389 0 Td
(these)Tj
2.2506 0 Td
(might)Tj
2.6022 0 Td
(differ)Tj
2.3868 0 Td
(by)Tj
1.1792 0 Td
(ethnic)Tj
2.7099 0 Td
(group)Tj
2.6079 0 Td
(is)Tj
-36.5837 -1.2982 Td
(important.)Tj
4.507 0 Td
(However,)Tj
4.0762 0 Td
(comparisons)Tj
5.3348 0 Td
(across)Tj
2.6815 0 Td
(such)Tj
2.058 0 Td
(a)Tj
0.6519 0 Td
(broad)Tj
2.5682 0 Td
(range)Tj
2.4605 0 Td
(of)Tj
1.0148 0 Td
(outcomes)Tj
4.0875 0 Td
(need)Tj
2.1486 0 Td
(the)Tj
1.4684 0 Td
(large)Tj
2.16 0 Td
(sam-)Tj
-35.2174 -1.2983 Td
(ple)Tj
1.4059 0 Td
(sizes)Tj
2.0466 0 Td
(to)Tj
1.0262 0 Td
(reliably)Tj
3.1691 0 Td
(identify)Tj
3.2938 0 Td
(ethnic)Tj
2.7099 0 Td
(differences)Tj
4.5638 0 Td
(in)Tj
1.0374 0 Td
(association.)Tj
-18.0565 -1.3039 Td
(We)Tj
1.61 0 Td
(have)Tj
2.0636 0 Td
(created)Tj
3.1181 0 Td
(a)Tj
0.6577 0 Td
(large)Tj
2.16 0 Td
(UK-based)Tj
4.2292 0 Td
(prospective)Tj
4.7849 0 Td
(cohort)Tj
2.8573 0 Td
(using)Tj
2.3867 0 Td
(linked)Tj
2.7326 0 Td
(electronic)Tj
4.1499 0 Td
(health)Tj
2.6816 0 Td
(re-)Tj
-34.6278 -1.2983 Td
(cords)Tj
2.4094 0 Td
(with)Tj
1.9956 0 Td
(detailed)Tj
3.3675 0 Td
(information)Tj
5.0797 0 Td
(on)Tj
1.2755 0 Td
(ethnic)Tj
2.7099 0 Td
(group,)Tj
2.829 0 Td
(cardiovascular)Tj
6.0037 0 Td
(risk)Tj
1.7178 0 Td
(factors)Tj
2.9027 0 Td
(and)Tj
1.7291 0 Td
(diagnoses)Tj
4.1159 0 Td
(in)Tj
-36.1358 -1.2982 Td
(order)Tj
2.4207 0 Td
(to)Tj
1.0262 0 Td
(address)Tj
3.2258 0 Td
(this)Tj
1.6724 0 Td
(gap)Tj
1.6384 0 Td
(in)Tj
1.0318 0 Td
(knowledge.[)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(])Tj
6.4006 0 Td
(Specifically,)Tj
4.9152 0 Td
(we)Tj
1.3267 0 Td
(sought)Tj
2.9026 0 Td
(to)Tj
1.0261 0 Td
(address)Tj
3.2259 0 Td
(the)Tj
1.474 0 Td
(following)Tj
-32.2864 -1.2983 Td
(objectives:)Tj
0 -1.9049 Td
(1.)Tj
1.2018 0 Td
(To)Tj
1.338 0 Td
(examine)Tj
3.6 0 Td
(the)Tj
1.4683 0 Td
(proportion)Tj
4.6318 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(total)Tj
2.0069 0 Td
(burden)Tj
3.1238 0 Td
(of)Tj
1.0148 0 Td
(CVD)Tj
2.313 0 Td
(comprised)Tj
4.4391 0 Td
(by)Tj
1.1848 0 Td
(specific)Tj
3.1918 0 Td
(cardiovascu-)Tj
-30.7954 -1.2982 Td
(lar)Tj
1.2699 0 Td
(diagnoses)Tj
4.1159 0 Td
(for)Tj
1.3833 0 Td
(White,)Tj
2.931 0 Td
(South)Tj
2.5569 0 Td
(Asian)Tj
2.5114 0 Td
(and)Tj
1.7292 0 Td
(Black)Tj
2.4037 0 Td
(patients,)Tj
3.5943 0 Td
(the)Tj
1.4684 0 Td
(largest)Tj
2.8176 0 Td
(ethnic)Tj
2.7099 0 Td
(groups)Tj
2.9707 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
-33.494 -1.2983 Td
(UK.)Tj
-1.2018 -1.8992 Td
(2.)Tj
1.2018 0 Td
(To)Tj
1.338 0 Td
(determine)Tj
4.3199 0 Td
(how)Tj
1.9389 0 Td
(South)Tj
2.5569 0 Td
(Asian)Tj
2.5171 0 Td
(and)Tj
1.7291 0 Td
(Black)Tj
2.3981 0 Td
(patients)Tj
3.3676 0 Td
(differ)Tj
2.3867 0 Td
(from)Tj
2.2054 0 Td
(White)Tj
2.7042 0 Td
(patients)Tj
3.3675 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(initial)Tj
-33.3353 -1.3039 Td
(lifetime)Tj
3.2485 0 Td
(diagnosis)Tj
3.9628 0 Td
(of)Tj
1.0148 0 Td
(cardiovascular)Tj
6.0038 0 Td
(disease,)Tj
3.2428 0 Td
(across)Tj
2.6759 0 Td
(a)Tj
0.6519 0 Td
(broad)Tj
2.5682 0 Td
(range)Tj
2.4605 0 Td
(of)Tj
1.0148 0 Td
(cardiovascular)Tj
-26.844 -1.2983 Td
(diagnoses.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 321.7889 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Ethnicity)Tj
3.9331 0 Td
(and)Tj
1.8567 0 Td
(the)Tj
1.5874 0 Td
(first)Tj
1.8 0 Td
(diagnosis)Tj
4.3654 0 Td
(of)Tj
1.0346 0 Td
(a)Tj
0.7654 0 Td
(wide)Tj
2.2394 0 Td
(range)Tj
2.7283 0 Td
(of)Tj
1.0418 0 Td
(cardiovasc)Tj
4.6914 0 Td
(ular)Tj
1.8567 0 Td
(diseases)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01789)Tj
4.089 0 Td
(45)Tj
0 g
2.0906 0 Td
(June)Tj
2.3528 0 Td
(9,)Tj
1.0417 0 Td
(2017)Tj
35.5113 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(17)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
36 685.6441 m
110.1543 685.6441 l
h
f*
163.2756 674.6457 m
181.0205 674.6457 l
h
f*
36 663.6472 m
109.9843 663.6472 l
h
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F9 1 Tf
1 TL
-0.025 Tc
0 0 Td
(The)Tj
1.5874 0 Td
(phenotype)Tj
4.1102 0 Td
(algorith)Tj
2.7851 0 Td
(ms)Tj
1.3961 0 Td
(described)Tj
3.8268 0 Td
(in)Tj
0.8858 0 Td
(this)Tj
1.5662 0 Td
(paper)Tj
-16.1576 -1.3748 Td
(are)Tj
1.3677 0 Td
(freely)Tj
2.2394 0 Td
(available)Tj
3.3803 0 Td
(via)Tj
1.2614 0 Td
(the)Tj
1.3678 0 Td
(CALIBER)Tj
3.5858 0 Td
(website)Tj
3.0473 0 Td
(at)Tj
0.83 0.64 0.02 0 k
-16.2497 -1.3748 Td
(www.calibe)Tj
4.2661 0 Td
(rresearch.or)Tj
4.5071 0 Td
(g)Tj
0 g
0.6945 0 Td
(and)Tj
1.5875 0 Td
(the)Tj
1.3677 0 Td
(CALIBER)Tj
3.5858 0 Td
(data)Tj
-16.0087 -1.3748 Td
(portal)Tj
2.3456 0 Td
(is)Tj
0.8363 0 Td
(available)Tj
3.3732 0 Td
(for)Tj
1.2614 0 Td
(consultati)Tj
3.5788 0 Td
(on)Tj
1.1693 0 Td
(online)Tj
2.4449 0 Td
(at)Tj
0.83 0.64 0.02 0 k
0.9 0 Td
(http://)Tj
-15.9095 -1.3748 Td
(www.calibe)Tj
4.2661 0 Td
(rresearch.or)Tj
4.5071 0 Td
(g)Tj
0 g
(.)Tj
/F8 1 Tf
-8.7732 -2.126 Td
(Funding:)Tj
/F9 1 Tf
3.5716 0 Td
(This)Tj
1.7788 0 Td
(study)Tj
2.2677 0 Td
(was)Tj
1.7008 0 Td
(supported)Tj
3.9969 0 Td
(by)Tj
1.1126 0 Td
(the)Tj
1.3677 0 Td
(National)Tj
-15.7961 -1.3748 Td
(Institute)Tj
3.2244 0 Td
(for)Tj
1.2543 0 Td
(Health)Tj
2.5725 0 Td
(Research)Tj
3.6992 0 Td
(\(RP-PG-04)Tj
4.089 0 Td
(0710314\))Tj
-14.8394 -1.3748 Td
(and)Tj
1.5874 0 Td
(the)Tj
1.3677 0 Td
(Wellcome)Tj
3.9047 0 Td
(Trust)Tj
2.1544 0 Td
(\(WT/086091/)Tj
4.9394 0 Td
(Z/08/Z\).)Tj
3.1536 0 Td
(The)Tj
-17.1072 -1.3748 Td
(study)Tj
2.2677 0 Td
(was)Tj
1.7008 0 Td
(carried)Tj
2.7638 0 Td
(out)Tj
1.4244 0 Td
(as)Tj
1.063 0 Td
(part)Tj
1.6725 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3748 0 Td
(CArdiovasc)Tj
4.1811 0 Td
(ular)Tj
-17.3977 -1.3749 Td
(disease)Tj
2.9905 0 Td
(research)Tj
3.4158 0 Td
(using)Tj
2.2606 0 Td
(LInked)Tj
2.7355 0 Td
(Bespoke)Tj
3.3803 0 Td
(studies)Tj
-14.7827 -1.3748 Td
(and)Tj
1.5874 0 Td
(Electronic)Tj
3.8551 0 Td
(health)Tj
2.4591 0 Td
(Records)Tj
3.3236 0 Td
(\(CALIBER)Tj
3.6709 0 Td
(\))Tj
-14.8961 -1.3748 Td
(programm)Tj
3.9614 0 Td
(e.)Tj
0.8646 0 Td
(HH)Tj
1.396 0 Td
(was)Tj
1.7079 0 Td
(supporte)Tj
3.2953 0 Td
(d)Tj
0.6945 0 Td
(by)Tj
1.1126 0 Td
(an)Tj
1.1197 0 Td
(award)Tj
2.4804 0 Td
(\(grant)Tj
-16.6324 -1.3748 Td
(MR/K00658)Tj
4.4858 0 Td
(4/1\))Tj
1.7362 0 Td
(to)Tj
0.9426 0 Td
(establish)Tj
3.4937 0 Td
(the)Tj
1.3748 0 Td
(Farr)Tj
1.6796 0 Td
(Institute)Tj
3.2173 0 Td
(of)Tj
-16.93 -1.3748 Td
(Health)Tj
2.5724 0 Td
(Informatics)Tj
4.4504 0 Td
(Research)Tj
3.6993 0 Td
(London)Tj
3.0543 0 Td
(at)Tj
-13.7764 -1.3748 Td
(UCLPartne)Tj
3.9897 0 Td
(rs,)Tj
1.1764 0 Td
(from)Tj
2.0056 0 Td
(the)Tj
1.3748 0 Td
(Medica)Tj
2.6787 0 Td
(l)Tj
0.4181 0 Td
(Researc)Tj
2.9977 0 Td
(h)Tj
0.6945 0 Td
(Council,)Tj
-15.3355 -1.3748 Td
(Arthritis)Tj
3.1535 0 Td
(Researc)Tj
2.9977 0 Td
(h)Tj
0.6945 0 Td
(UK,)Tj
1.559 0 Td
(British)Tj
2.5867 0 Td
(Heart)Tj
2.2181 0 Td
(Foundation,)Tj
-13.2095 -1.3749 Td
(Cancer)Tj
2.7921 0 Td
(Researc)Tj
2.9977 0 Td
(h)Tj
0.6945 0 Td
(UK,)Tj
1.559 0 Td
(Chief)Tj
2.0906 0 Td
(Scientist)Tj
3.3803 0 Td
(Office,)Tj
-13.5142 -1.3748 Td
(Economic)Tj
3.9047 0 Td
(and)Tj
1.5874 0 Td
(Social)Tj
2.4449 0 Td
(Research)Tj
3.6993 0 Td
(Council,)Tj
-11.6363 -1.3748 Td
(Engineering)Tj
4.5992 0 Td
(and)Tj
1.5874 0 Td
(Physical)Tj
3.2882 0 Td
(Sciences)Tj
3.5221 0 Td
(Researc)Tj
2.9977 0 Td
(h)Tj
-15.9946 -1.3748 Td
(Council,)Tj
3.196 0 Td
(National)Tj
3.2386 0 Td
(Institute)Tj
3.2245 0 Td
(for)Tj
1.2543 0 Td
(Health)Tj
2.5725 0 Td
(Research,)Tj
-13.4859 -1.3748 Td
(National)Tj
3.2386 0 Td
(Institute)Tj
3.2244 0 Td
(for)Tj
1.2543 0 Td
(Social)Tj
2.452 0 Td
(Care)Tj
1.8922 0 Td
(and)Tj
1.5874 0 Td
(Health)Tj
-13.6489 -1.3748 Td
(Research)Tj
3.6992 0 Td
(\(NIHR\),)Tj
3.0756 0 Td
(and)Tj
1.5874 0 Td
(Wellcome)Tj
3.9048 0 Td
(Trust.)Tj
2.374 0 Td
(HH)Tj
1.3961 0 Td
(is)Tj
0.8291 0 Td
(a)Tj
-16.8662 -1.3748 Td
(NIHR)Tj
2.2393 0 Td
(Senior)Tj
2.615 0 Td
(Investiga)Tj
3.3308 0 Td
(tor)Tj
1.2614 0 Td
(\(NF-SI-0616)Tj
4.6063 0 Td
(-10066.\).)Tj
-14.0528 -1.3749 Td
(RM)Tj
1.559 0 Td
(was)Tj
1.7079 0 Td
(supporte)Tj
3.2953 0 Td
(d)Tj
0.6945 0 Td
(by)Tj
1.1126 0 Td
(a)Tj
0.6449 0 Td
(Sir)Tj
1.2472 0 Td
(Henry)Tj
2.4308 0 Td
(Wellcome)Tj
-12.6922 -1.3819 Td
(Postdocto)Tj
3.7701 0 Td
(ral)Tj
1.1409 0 Td
(Fellowship)Tj
4.1245 0 Td
(from)Tj
2.0126 0 Td
(the)Tj
1.3677 0 Td
(Wellcome)Tj
3.9048 0 Td
(Trust)Tj
-16.3206 -1.3748 Td
(\(WT/201375/)Tj
4.9394 0 Td
(Z/16/Z\).)Tj
3.1535 0 Td
(ADS)Tj
1.8567 0 Td
(was)Tj
1.7079 0 Td
(supporte)Tj
3.2953 0 Td
(d)Tj
0.6945 0 Td
(by)Tj
1.1126 0 Td
(a)Tj
-16.7599 -1.3748 Td
(Wellcome)Tj
3.9047 0 Td
(Trust)Tj
2.1473 0 Td
(Clinical)Tj
2.8346 0 Td
(Research)Tj
3.6993 0 Td
(Training)Tj
-12.5859 -1.3748 Td
(Fellowship)Tj
4.1244 0 Td
(\(WT/0938/)Tj
3.9898 0 Td
(30/Z/10/Z\))Tj
3.9118 0 Td
(.)Tj
0.4465 0 Td
(LS)Tj
1.2189 0 Td
(was)Tj
-13.6914 -1.3748 Td
(supported)Tj
3.9897 0 Td
(by)Tj
1.1197 0 Td
(a)Tj
0.6378 0 Td
(Wellcome)Tj
3.9048 0 Td
(Trust)Tj
2.1543 0 Td
(Senior)Tj
2.6079 0 Td
(Research)Tj
-14.4142 -1.3748 Td
(Fellowship)Tj
4.1244 0 Td
(in)Tj
0.8858 0 Td
(Clinical)Tj
2.8347 0 Td
(Science)Tj
3.0969 0 Td
(\(WT/098504/)Tj
4.9394 0 Td
(Z/12/Z\).)Tj
-15.8812 -1.3748 Td
(This)Tj
1.7787 0 Td
(article)Tj
2.4378 0 Td
(presents)Tj
3.4158 0 Td
(independe)Tj
3.8197 0 Td
(nt)Tj
0.9496 0 Td
(research)Tj
3.4158 0 Td
(funded)Tj
-15.8174 -1.3749 Td
(in)Tj
0.8858 0 Td
(part)Tj
1.6795 0 Td
(by)Tj
1.1126 0 Td
(the)Tj
1.3678 0 Td
(NIHR.)Tj
2.4661 0 Td
(The)Tj
1.5874 0 Td
(views)Tj
2.3174 0 Td
(expressed)Tj
4.0039 0 Td
(are)Tj
1.3678 0 Td
(those)Tj
-16.7883 -1.3748 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(authors)Tj
3.0473 0 Td
(and)Tj
1.5874 0 Td
(not)Tj
1.4244 0 Td
(necessa)Tj
2.9977 0 Td
(rily)Tj
1.3393 0 Td
(those)Tj
2.2607 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-15.9237 -1.3748 Td
(NHS,)Tj
2.1472 0 Td
(the)Tj
1.3677 0 Td
(NIHR)Tj
2.2394 0 Td
(or)Tj
0.9992 0 Td
(the)Tj
1.3678 0 Td
(Department)Tj
4.5921 0 Td
(of)Tj
0.9496 0 Td
(Health.)Tj
2.7993 0 Td
(The)Tj
-16.4623 -1.3748 Td
(funders)Tj
3.0472 0 Td
(had)Tj
1.5874 0 Td
(no)Tj
1.1693 0 Td
(role)Tj
1.6087 0 Td
(in)Tj
0.8929 0 Td
(study)Tj
2.2607 0 Td
(design,)Tj
2.8984 0 Td
(data)Tj
1.793 0 Td
(collection)Tj
-15.2576 -1.3748 Td
(and)Tj
1.5874 0 Td
(analysis,)Tj
3.4087 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1464 0 Td
(or)Tj
0.9993 0 Td
(preparation)Tj
4.4362 0 Td
(of)Tj
-17.8229 -1.3748 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
/F8 1 Tf
-1.3677 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F9 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
endstream
endobj
63 0 obj
<>stream
endstream
endobj
64 0 obj
<>stream
endstream
endobj
65 0 obj
<>stream
endstream
endobj
66 0 obj
<>stream
endstream
endobj
67 0 obj
<>stream
BT
10.3394 -53.7523 Td
(exist.)Tj
ET
Q
endstream
endobj
68 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 70 0 R/Contents 71 0 R/TrimBox[0 0 612 792]>>
endobj
70 0 obj
[72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R]
endobj
72 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref025)>>
endobj
73 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref026)>>
endobj
74 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref031)>>
endobj
75 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref032)>>
endobj
76 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref033)>>
endobj
77 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref034)>>
endobj
78 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.s005)>>
endobj
79 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref035)>>
endobj
80 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref033)>>
endobj
81 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref035)>>
endobj
82 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.s006)>>
endobj
83 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref036)>>
endobj
84 0 obj
<>/Border[0 0 0]/A 85 0 R>>
endobj
85 0 obj
<>
endobj
71 0 obj
[86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R]
endobj
86 0 obj
<>stream
q
0.83 0.64 0.02 0 k
526.2236 607.8614 m
535.6913 607.8614 l
h
f*
225.5244 594.8787 m
235.0488 594.8787 l
h
f*
240.2079 594.8787 m
249.7323 594.8787 l
h
f*
340.611 542.8346 m
350.1354 542.8346 l
h
f*
352.4031 542.8346 m
361.8709 542.8346 l
h
f*
522.652 364.3654 m
532.1764 364.3654 l
h
f*
296.3339 338.4 m
320.6551 338.4 l
h
f*
265.2094 198.9354 m
274.6772 198.9354 l
h
f*
203.4142 185.8961 m
212.9386 185.8961 l
h
f*
553.7764 159.9307 m
563.3008 159.9307 l
h
f*
218.8346 146.948 m
243.1559 146.948 l
h
f*
414.822 120.926 m
424.3465 120.926 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(3.)Tj
1.2018 0 Td
(To)Tj
1.338 0 Td
(determine)Tj
4.3199 0 Td
(whether)Tj
3.4753 0 Td
(any)Tj
1.6611 0 Td
(associations)Tj
4.9889 0 Td
(found)Tj
2.6192 0 Td
(are)Tj
1.4457 0 Td
(independent)Tj
5.2781 0 Td
(of)Tj
1.0148 0 Td
(common)Tj
3.8437 0 Td
(cardiovascular)Tj
-29.9847 -1.3039 Td
(risk)Tj
1.7121 0 Td
(factors)Tj
2.9027 0 Td
(such)Tj
2.0636 0 Td
(as)Tj
1.0148 0 Td
(age,)Tj
1.7688 0 Td
(sex,)Tj
1.6951 0 Td
(social)Tj
2.4548 0 Td
(deprivation,)Tj
5.0627 0 Td
(hypertension)Tj
5.4708 0 Td
(and)Tj
1.7291 0 Td
(diabetes.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 656.9574 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Methods)Tj
/F0 1 Tf
0 -1.5023 Td
(Data)Tj
2.3102 0 Td
(sources)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 621.9212 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Anonymised)Tj
5.3631 0 Td
(patient)Tj
3.0047 0 Td
(records)Tj
3.2031 0 Td
(were)Tj
2.126 0 Td
(selected)Tj
3.3448 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.474 0 Td
(Clinical)Tj
3.3108 0 Td
(disease)Tj
3.0217 0 Td
(research)Tj
3.5547 0 Td
(using)Tj
2.3867 0 Td
(LInked)Tj
-32.995 -1.2982 Td
(Bespoke)Tj
3.5206 0 Td
(studies)Tj
2.9763 0 Td
(and)Tj
1.7178 0 Td
(Electronic)Tj
4.2916 0 Td
(health)Tj
2.6646 0 Td
(Records)Tj
3.4469 0 Td
(\(CALIBER\))Tj
4.8869 0 Td
(programme)Tj
4.9436 0 Td
(described[)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(])Tj
5.6749 0 Td
(and)Tj
1.7178 0 Td
(vali-)Tj
-35.841 -1.2983 Td
(dated[)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(])Tj
5.5275 0 Td
(elsewhere.)Tj
4.3313 0 Td
(In)Tj
1.1112 0 Td
(brief,)Tj
2.3017 0 Td
(patients)Tj
3.3675 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.474 0 Td
(cohort)Tj
2.8517 0 Td
(were)Tj
2.1259 0 Td
(drawn)Tj
2.7836 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(Clinical)Tj
3.3165 0 Td
(Practice)Tj
-34.2479 -1.3039 Td
(Research)Tj
3.804 0 Td
(Database)Tj
3.8494 0 Td
(\(CPRD\))Tj
3.481 0 Td
(which)Tj
2.6475 0 Td
(also)Tj
1.7688 0 Td
(provided)Tj
3.8154 0 Td
(data)Tj
1.9162 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(primary)Tj
3.4583 0 Td
(care)Tj
1.8708 0 Td
(medical)Tj
3.3619 0 Td
(record.)Tj
-33.647 -1.2983 Td
(Patients)Tj
3.4072 0 Td
(registered)Tj
4.1555 0 Td
(in)Tj
1.0318 0 Td
(practices)Tj
3.7418 0 Td
(submitting)Tj
4.5807 0 Td
(linkable)Tj
3.3902 0 Td
(data)Tj
1.9106 0 Td
(to)Tj
1.0261 0 Td
(CPRD,)Tj
3.0274 0 Td
(covering)Tj
3.6793 0 Td
(approximately)Tj
5.9754 0 Td
(4%)Tj
-35.926 -1.2982 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(English)Tj
3.2031 0 Td
(population,)Tj
4.8189 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.126 0 Td
(found)Tj
2.6192 0 Td
(to)Tj
1.0205 0 Td
(be)Tj
1.1508 0 Td
(representative)Tj
5.8393 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(English)Tj
3.2031 0 Td
(population)Tj
4.5921 0 Td
(in)Tj
-35.5972 -1.3039 Td
(terms)Tj
2.4944 0 Td
(of)Tj
1.0148 0 Td
(age,)Tj
1.7688 0 Td
(gender)Tj
2.9764 0 Td
(and)Tj
1.7291 0 Td
(ethnicity.[)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(33)Tj
0 g
(])Tj
-8.7873 -1.2983 Td
(Further)Tj
3.2711 0 Td
(data)Tj
1.9106 0 Td
(on)Tj
1.2755 0 Td
(the)Tj
1.4741 0 Td
(cohort)Tj
2.8516 0 Td
(patients)Tj
3.3675 0 Td
(was)Tj
1.7008 0 Td
(drawn)Tj
2.7836 0 Td
(from)Tj
2.2053 0 Td
(three)Tj
2.2677 0 Td
(other)Tj
2.3471 0 Td
(linked)Tj
2.7326 0 Td
(clinical)Tj
3.0727 0 Td
(datasets:)Tj
3.583 0 Td
(the)Tj
-36.0394 -1.2983 Td
(Myocardial)Tj
4.7791 0 Td
(Ischaemia)Tj
4.2463 0 Td
(National)Tj
3.6907 0 Td
(Audit)Tj
2.5285 0 Td
(Project)Tj
3.0557 0 Td
(\(MINAP\))Tj
4.1159 0 Td
(registry,)Tj
3.4582 0 Td
(Hospital)Tj
3.617 0 Td
(Episodes)Tj
3.7531 0 Td
(Statistics)Tj
-33.2445 -1.3039 Td
(\(HES\))Tj
2.7099 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(UK)Tj
1.6271 0 Td
(national)Tj
3.5036 0 Td
(death)Tj
2.4321 0 Td
(registry)Tj
3.2314 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.474 0 Td
(Office)Tj
2.6532 0 Td
(for)Tj
1.389 0 Td
(National)Tj
3.6907 0 Td
(Statistics)Tj
3.702 0 Td
(\(ONS\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 473.4425 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Study)Tj
2.7543 0 Td
(population)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 456.4913 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(We)Tj
1.6043 0 Td
(studied)Tj
3.1522 0 Td
(1,068,318)Tj
4.0024 0 Td
(patients)Tj
3.3619 0 Td
(registered)Tj
4.1556 0 Td
(between)Tj
3.5263 0 Td
(January)Tj
3.3165 0 Td
(1997)Tj
2.1203 0 Td
(and)Tj
1.7291 0 Td
(March)Tj
2.8686 0 Td
(2010)Tj
2.1203 0 Td
(from)Tj
2.2054 0 Td
(225)Tj
1.6441 0 Td
(gen-)Tj
-35.807 -1.3039 Td
(eral)Tj
1.6951 0 Td
(practices)Tj
3.736 0 Td
(across)Tj
2.6816 0 Td
(England)Tj
3.5602 0 Td
(submitting)Tj
4.5751 0 Td
(data)Tj
1.9162 0 Td
(to)Tj
1.0262 0 Td
(CPRD.)Tj
3.0274 0 Td
(We)Tj
1.6044 0 Td
(required)Tj
3.6396 0 Td
(that)Tj
1.7802 0 Td
(at)Tj
0.9524 0 Td
(study)Tj
2.3868 0 Td
(entry)Tj
-32.5812 -1.2982 Td
(patients)Tj
3.3675 0 Td
(were)Tj
2.1203 0 Td
(aged)Tj
/F5 1 Tf
0 Tc
2.0693 0 Td
()Tj
/F7 1 Tf
-0.004 Tc
(30)Tj
1.9445 0 Td
(years,)Tj
2.4888 0 Td
(free)Tj
1.7291 0 Td
(of)Tj
1.0148 0 Td
(diagnosed)Tj
4.2803 0 Td
(CVD)Tj
2.3131 0 Td
(and)Tj
1.7291 0 Td
(had)Tj
1.7121 0 Td
(been)Tj
2.1203 0 Td
(followed-up)Tj
5.0457 0 Td
(for)Tj
1.3889 0 Td
(at)Tj
0.9525 0 Td
(least)Tj
-34.2763 -1.2983 Td
(one)Tj
1.6951 0 Td
(year.)Tj
2.1316 0 Td
(We)Tj
1.6101 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5761 0 Td
(impose)Tj
3.1124 0 Td
(an)Tj
1.2019 0 Td
(upper)Tj
2.5795 0 Td
(age)Tj
1.542 0 Td
(limit)Tj
2.1203 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(older)Tj
2.296 0 Td
(patient)Tj
3.0047 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(cohort)Tj
2.8573 0 Td
(was)Tj
1.7008 0 Td
(109.)Tj
-34.6731 -1.3039 Td
(We)Tj
1.61 0 Td
(used)Tj
2.058 0 Td
(the)Tj
1.4683 0 Td
(entire)Tj
2.5512 0 Td
(medical)Tj
3.3618 0 Td
(history)Tj
3.0104 0 Td
(available)Tj
3.668 0 Td
(on)Tj
1.2756 0 Td
(each)Tj
2.0239 0 Td
(patient)Tj
3.0104 0 Td
(to)Tj
1.0261 0 Td
(confirm)Tj
3.4413 0 Td
(they)Tj
1.9275 0 Td
(were)Tj
2.1203 0 Td
(free)Tj
1.7291 0 Td
(of)Tj
1.0148 0 Td
(diag-)Tj
-35.2967 -1.2983 Td
(nosed)Tj
2.5851 0 Td
(CVD.)Tj
2.5399 0 Td
(The)Tj
1.7858 0 Td
(period)Tj
2.8289 0 Td
(covered)Tj
3.3562 0 Td
(by)Tj
1.1792 0 Td
(medical)Tj
3.3619 0 Td
(history)Tj
3.0047 0 Td
(prior)Tj
2.2564 0 Td
(to)Tj
1.0261 0 Td
(study)Tj
2.3868 0 Td
(entry)Tj
2.3187 0 Td
(ranged)Tj
2.9877 0 Td
(from)Tj
2.2053 0 Td
(20)Tj
1.1736 0 Td
(years)Tj
-34.9963 -1.2982 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(stipulated)Tj
4.1216 0 Td
(minimum)Tj
4.2859 0 Td
(period)Tj
2.8347 0 Td
(of)Tj
1.0148 0 Td
(1)Tj
0.6973 0 Td
(year,)Tj
2.1316 0 Td
(which)Tj
2.6476 0 Td
(previous)Tj
3.651 0 Td
(research)Tj
3.5546 0 Td
(has)Tj
1.542 0 Td
(found)Tj
2.6192 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(a)Tj
0.652 0 Td
(suffi-)Tj
-34.4237 -1.304 Td
(cient)Tj
2.1769 0 Td
(period)Tj
2.8347 0 Td
(to)Tj
1.0261 0 Td
(ensure)Tj
2.8743 0 Td
(accurate)Tj
3.5603 0 Td
(assessment)Tj
4.6091 0 Td
(of)Tj
1.0148 0 Td
(baseline)Tj
3.4299 0 Td
(history)Tj
3.0104 0 Td
(of)Tj
1.0148 0 Td
(prior)Tj
2.2507 0 Td
(diagnoses.[)Tj
0.83 0.64 0.02 0 k
(34)Tj
0 g
(])Tj
5.9754 0 Td
(Women)Tj
-33.7774 -1.2982 Td
(who)Tj
1.9388 0 Td
(were)Tj
2.1203 0 Td
(pregnant)Tj
3.8268 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(6)Tj
0.6973 0 Td
(months)Tj
3.2825 0 Td
(before)Tj
2.7383 0 Td
(study)Tj
2.3924 0 Td
(entry)Tj
2.313 0 Td
(were)Tj
2.126 0 Td
(excluded,)Tj
4.0082 0 Td
(as)Tj
1.0148 0 Td
(were)Tj
2.1203 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
2.0013 0 Td
(no)Tj
-36.4533 -1.2983 Td
(ethnicity)Tj
3.7303 0 Td
(recorded.)Tj
4.0195 0 Td
(\(See)Tj
0.83 0.64 0.02 0 k
1.8822 0 Td
(S1)Tj
1.1679 0 Td
(Fig)Tj
0 g
1.4853 0 Td
(for)Tj
1.3833 0 Td
(study)Tj
2.3925 0 Td
(flow)Tj
1.9445 0 Td
(diagram.\))Tj
4.1045 0 Td
(We)Tj
1.6044 0 Td
(used)Tj
2.0637 0 Td
(an)Tj
1.2018 0 Td
(open)Tj
2.2167 0 Td
(cohort)Tj
2.8517 0 Td
(design,)Tj
3.0387 0 Td
(so)Tj
-35.087 -1.2983 Td
(patients)Tj
3.3675 0 Td
(entered)Tj
3.2371 0 Td
(the)Tj
1.4684 0 Td
(study)Tj
2.3867 0 Td
(when)Tj
2.4095 0 Td
(they)Tj
1.9218 0 Td
(met)Tj
1.7632 0 Td
(the)Tj
1.4683 0 Td
(inclusion)Tj
3.9175 0 Td
(criteria.)Tj
3.2995 0 Td
(Patients)Tj
3.4129 0 Td
(were)Tj
2.1203 0 Td
(censored)Tj
3.804 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
-35.8523 -1.3039 Td
(earliest)Tj
3.0443 0 Td
(date)Tj
1.9049 0 Td
(from)Tj
2.2054 0 Td
(among:)Tj
3.2201 0 Td
(the)Tj
1.4683 0 Td
(date)Tj
1.9049 0 Td
(of)Tj
1.0148 0 Td
(first)Tj
1.8028 0 Td
(CVD)Tj
2.3131 0 Td
(diagnosis,)Tj
4.1839 0 Td
(date)Tj
1.9049 0 Td
(of)Tj
1.0147 0 Td
(death)Tj
2.4322 0 Td
(from)Tj
2.2053 0 Td
(other)Tj
2.3471 0 Td
(causes,)Tj
-32.9667 -1.2982 Td
(date)Tj
1.9048 0 Td
(leaving)Tj
3.0557 0 Td
(the)Tj
1.4684 0 Td
(practice)Tj
3.3789 0 Td
(or)Tj
1.0998 0 Td
(date)Tj
1.9049 0 Td
(of)Tj
1.0148 0 Td
(last)Tj
1.559 0 Td
(practice)Tj
3.3789 0 Td
(data)Tj
1.9105 0 Td
(collection.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 269.0078 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Exposure)Tj
4.3984 0 Td
(variableethnic)Tj
6.8505 0 Td
(group)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 252 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(In)Tj
1.1055 0 Td
(the)Tj
1.474 0 Td
(United)Tj
3.0217 0 Td
(Kingdom,)Tj
4.2519 0 Td
(recording)Tj
4.1272 0 Td
(of)Tj
1.0148 0 Td
(patients')Tj
3.583 0 Td
(ethnic)Tj
2.7042 0 Td
(group)Tj
2.6136 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.1203 0 Td
(mandated)Tj
4.2349 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
-32.8249 -1.2982 Td
(National)Tj
3.6906 0 Td
(Health)Tj
2.914 0 Td
(Service)Tj
3.0614 0 Td
(since)Tj
2.2451 0 Td
(1991.)Tj
2.347 0 Td
(Patients)Tj
3.4073 0 Td
(are)Tj
1.4513 0 Td
(asked)Tj
2.4604 0 Td
(to)Tj
1.0262 0 Td
(self-classify,)Tj
4.9492 0 Td
(specifying)Tj
4.235 0 Td
(the)Tj
1.474 0 Td
(ethnic)Tj
-33.2615 -1.3039 Td
(group)Tj
2.6078 0 Td
(to)Tj
1.0261 0 Td
(which)Tj
2.6476 0 Td
(they)Tj
1.9275 0 Td
(belong)Tj
2.914 0 Td
(when)Tj
2.4038 0 Td
(they)Tj
1.9275 0 Td
(access)Tj
2.6419 0 Td
(either)Tj
2.5342 0 Td
(primary)Tj
3.4582 0 Td
(or)Tj
1.0942 0 Td
(secondary)Tj
4.2746 0 Td
(care.)Tj
-28.2612 -1.2983 Td
(The)Tj
1.7858 0 Td
(completeness)Tj
5.5729 0 Td
(of)Tj
1.0148 0 Td
(ethnicity)Tj
3.7303 0 Td
(data)Tj
1.9106 0 Td
(has)Tj
1.542 0 Td
(increased)Tj
4.0025 0 Td
(over)Tj
1.9786 0 Td
(time,)Tj
2.2507 0 Td
(with)Tj
1.9955 0 Td
(substantial)Tj
4.5071 0 Td
(increases)Tj
3.8324 0 Td
(in)Tj
-35.3194 -1.2983 Td
(HES)Tj
2.0295 0 Td
(since)Tj
2.2451 0 Td
(2000[)Tj
0.83 0.64 0.02 0 k
(35)Tj
0 g
(])Tj
3.753 0 Td
(and)Tj
1.7291 0 Td
(in)Tj
1.0375 0 Td
(CPRD)Tj
2.8006 0 Td
(since)Tj
2.2451 0 Td
(2006)Tj
2.1203 0 Td
(when)Tj
2.4037 0 Td
(recording)Tj
4.1272 0 Td
(in)Tj
1.0375 0 Td
(primary)Tj
3.4526 0 Td
(care)Tj
1.8708 0 Td
(was)Tj
1.7008 0 Td
(incentivised.)Tj
-32.5528 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(33)Tj
0 g
(])Tj
1.8481 0 Td
(We)Tj
1.6101 0 Td
(used)Tj
2.0636 0 Td
(information)Tj
5.074 0 Td
(on)Tj
1.2756 0 Td
(ethnic)Tj
2.7099 0 Td
(group)Tj
2.6078 0 Td
(recorded)Tj
3.7928 0 Td
(in)Tj
1.0374 0 Td
(both)Tj
2.058 0 Td
(CPRD)Tj
2.8006 0 Td
(\(47%\))Tj
2.6078 0 Td
(and)Tj
1.7348 0 Td
(HES)Tj
2.0296 0 Td
(\(53%\),)Tj
-33.2501 -1.2982 Td
(resolving)Tj
3.8607 0 Td
(any)Tj
1.6611 0 Td
(conflicts)Tj
3.583 0 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.4683 0 Td
(two)Tj
1.7121 0 Td
(data)Tj
1.9162 0 Td
(sources)Tj
3.1918 0 Td
(using)Tj
2.3924 0 Td
(a)Tj
0.652 0 Td
(defined)Tj
3.2258 0 Td
(and)Tj
1.7291 0 Td
(previously)Tj
4.354 0 Td
(validated)Tj
-33.2728 -1.2983 Td
(algorithm,)Tj
4.3823 0 Td
(which)Tj
2.6475 0 Td
(found)Tj
2.6192 0 Td
(distribution)Tj
4.9663 0 Td
(of)Tj
1.0148 0 Td
(ethnic)Tj
2.7099 0 Td
(groups)Tj
2.9707 0 Td
(similar)Tj
2.9877 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(national)Tj
3.5036 0 Td
(UK)Tj
1.627 0 Td
(Census.[)Tj
0.83 0.64 0.02 0 k
(35)Tj
0 g
(])Tj
-31.9235 -1.2983 Td
(\(See)Tj
0.83 0.64 0.02 0 k
1.8821 0 Td
(S2)Tj
1.1679 0 Td
(Fig)Tj
0 g
1.4854 0 Td
(for)Tj
1.3833 0 Td
(algorithm)Tj
4.1555 0 Td
(and)Tj
1.7291 0 Td
(source)Tj
2.8347 0 Td
(of)Tj
1.0148 0 Td
(ethnicity)Tj
3.7303 0 Td
(codes.\))Tj
3.0274 0 Td
(Patients)Tj
3.4129 0 Td
(were)Tj
2.1203 0 Td
(categorised)Tj
4.7225 0 Td
(as)Tj
1.0148 0 Td
(White,)Tj
-33.681 -1.3039 Td
(South)Tj
2.5568 0 Td
(Asian,)Tj
2.7382 0 Td
(Black,)Tj
2.6249 0 Td
(or)Tj
1.0998 0 Td
(Other/Mixed)Tj
5.4935 0 Td
(ethnic)Tj
2.7099 0 Td
(groups;)Tj
3.1918 0 Td
(these)Tj
2.2564 0 Td
(groups)Tj
2.9707 0 Td
(reflect)Tj
2.6929 0 Td
(the)Tj
1.4683 0 Td
(most)Tj
2.2054 0 Td
(prevalent)Tj
3.9401 0 Td
(eth-)Tj
-35.9487 -1.2983 Td
(nic)Tj
1.4569 0 Td
(groups)Tj
2.9707 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(2011)Tj
2.1204 0 Td
(Census)Tj
3.1067 0 Td
(in)Tj
1.0375 0 Td
(England)Tj
3.5603 0 Td
(and)Tj
1.7291 0 Td
(Wales.[)Tj
0.83 0.64 0.02 0 k
(36)Tj
0 g
(])Tj
4.5071 0 Td
(The)Tj
1.7801 0 Td
(White)Tj
2.7042 0 Td
(group)Tj
2.6079 0 Td
(included)Tj
3.7134 0 Td
(White)Tj
-33.8001 -1.2982 Td
(British,)Tj
3.118 0 Td
(White)Tj
2.6986 0 Td
(European)Tj
4.1216 0 Td
(and)Tj
1.7291 0 Td
(other)Tj
2.347 0 Td
(White)Tj
2.7043 0 Td
(Groups.)Tj
3.4469 0 Td
(South)Tj
2.5568 0 Td
(Asian)Tj
2.5115 0 Td
(included)Tj
3.7134 0 Td
(patients)Tj
3.3675 0 Td
(from)Tj
2.2053 0 Td
(Indian,)Tj
-34.52 -1.3039 Td
(Pakistani,)Tj
4.1102 0 Td
(Bangladeshi)Tj
5.0343 0 Td
(and)Tj
1.7291 0 Td
(other)Tj
2.3471 0 Td
(Asian)Tj
2.5171 0 Td
(ethnic)Tj
2.7099 0 Td
(groups,)Tj
3.1918 0 Td
(including)Tj
4.0422 0 Td
(Asian)Tj
2.5171 0 Td
(British.)Tj
3.1181 0 Td
(Black)Tj
2.3981 0 Td
(included)Tj
-33.715 -1.2983 Td
(those)Tj
2.3357 0 Td
(belonging)Tj
4.2009 0 Td
(to)Tj
1.0205 0 Td
(African,)Tj
3.4639 0 Td
(Caribbean)Tj
4.3766 0 Td
(or)Tj
1.0999 0 Td
(other)Tj
2.3471 0 Td
(Black)Tj
2.3981 0 Td
(groups,)Tj
3.1974 0 Td
(including)Tj
4.0422 0 Td
(Black)Tj
2.3981 0 Td
(British.)Tj
3.1181 0 Td
(The)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 321.7889 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Ethnicity)Tj
3.9331 0 Td
(and)Tj
1.8567 0 Td
(the)Tj
1.5874 0 Td
(first)Tj
1.8 0 Td
(diagnosis)Tj
4.3654 0 Td
(of)Tj
1.0346 0 Td
(a)Tj
0.7654 0 Td
(wide)Tj
2.2394 0 Td
(range)Tj
2.7283 0 Td
(of)Tj
1.0418 0 Td
(cardiovasc)Tj
4.6914 0 Td
(ular)Tj
1.8567 0 Td
(diseases)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01789)Tj
4.089 0 Td
(45)Tj
0 g
2.0906 0 Td
(June)Tj
2.3528 0 Td
(9,)Tj
1.0417 0 Td
(2017)Tj
35.5113 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
87 0 obj
<>stream
endstream
endobj
88 0 obj
<>stream
endstream
endobj
89 0 obj
<>stream
endstream
endobj
90 0 obj
<>stream
endstream
endobj
91 0 obj
<>stream
endstream
endobj
92 0 obj
<>stream
endstream
endobj
93 0 obj
<>stream
endstream
endobj
94 0 obj
<>stream
endstream
endobj
95 0 obj
<>stream
endstream
endobj
96 0 obj
<>stream
endstream
endobj
97 0 obj
<>stream
endstream
endobj
98 0 obj
<>stream
endstream
endobj
99 0 obj
<>stream
endstream
endobj
100 0 obj
<>stream
BT
66.402 0 Td
(17)Tj
ET
Q
endstream
endobj
101 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 103 0 R/Contents 104 0 R/TrimBox[0 0 612 792]>>
endobj
103 0 obj
[105 0 R 106 0 R 107 0 R 108 0 R 109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R]
endobj
105 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref037)>>
endobj
106 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref038)>>
endobj
107 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref039)>>
endobj
108 0 obj
<>/Border[0 0 0]/A 115 0 R>>
endobj
115 0 obj
<>
endobj
109 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref027)>>
endobj
110 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref030)>>
endobj
111 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref031)>>
endobj
112 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref040)>>
endobj
113 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref030)>>
endobj
114 0 obj
<>/Border[0 0 0]/A 116 0 R>>
endobj
116 0 obj
<>
endobj
104 0 obj
[117 0 R 118 0 R 119 0 R 120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R]
endobj
117 0 obj
<>stream
q
0.83 0.64 0.02 0 k
243.7228 584.8441 m
253.2472 584.8441 l
h
f*
538.2992 558.8787 m
547.8236 558.8787 l
h
f*
422.1921 519.874 m
431.7165 519.874 l
h
f*
389.3102 454.8472 m
543.4583 454.8472 l
h
f*
331.937 411.3638 m
341.4614 411.3638 l
h
f*
343.6724 411.3638 m
353.1969 411.3638 l
h
f*
355.4646 411.3638 m
364.989 411.3638 l
h
f*
289.9843 281.3669 m
299.5087 281.3669 l
h
f*
536.0315 242.3622 m
545.4992 242.3622 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Other/)Tj
2.9139 0 Td
(Mixed)Tj
2.8007 0 Td
(group)Tj
2.6078 0 Td
(included)Tj
3.7077 0 Td
(those)Tj
2.3414 0 Td
(from)Tj
2.2054 0 Td
(any)Tj
1.6554 0 Td
(mixed)Tj
2.7269 0 Td
(ethnic)Tj
2.7042 0 Td
(group)Tj
2.6079 0 Td
(and)Tj
1.7348 0 Td
(other)Tj
2.347 0 Td
(small)Tj
2.3244 0 Td
(minority)Tj
-32.6775 -1.3039 Td
(ethnic)Tj
2.7099 0 Td
(groups,)Tj
3.1917 0 Td
(including)Tj
4.0422 0 Td
(Japanese)Tj
3.6907 0 Td
(and)Tj
1.7291 0 Td
(Chinese.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 667.9559 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Covariates)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 650.948 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Baseline)Tj
3.5035 0 Td
(cardiovascular)Tj
6.0038 0 Td
(risk)Tj
1.7121 0 Td
(factors)Tj
2.9027 0 Td
(were)Tj
2.1259 0 Td
(obtained)Tj
3.7304 0 Td
(from)Tj
2.2053 0 Td
(CPRD,)Tj
3.0274 0 Td
(recorded)Tj
3.7928 0 Td
(during)Tj
2.931 0 Td
(primary)Tj
3.4525 0 Td
(care)Tj
-35.3874 -1.3039 Td
(consultations.)Tj
5.7713 0 Td
(For)Tj
1.627 0 Td
(body)Tj
2.2167 0 Td
(mass)Tj
2.194 0 Td
(index)Tj
2.4548 0 Td
(\(BMI\),)Tj
2.9367 0 Td
(systolic)Tj
3.1407 0 Td
(blood)Tj
2.5115 0 Td
(pressure)Tj
3.5773 0 Td
(\(SBP\),)Tj
2.7383 0 Td
(total)Tj
2.0069 0 Td
(cholesterol)Tj
-31.1752 -1.2982 Td
(\(TChol\))Tj
3.4525 0 Td
(and)Tj
1.7291 0 Td
(HDL)Tj
2.2621 0 Td
(cholesterol)Tj
4.5581 0 Td
(\(HDL\),)Tj
3.1691 0 Td
(the)Tj
1.4683 0 Td
(most)Tj
2.2054 0 Td
(recent)Tj
2.7099 0 Td
(measurement)Tj
5.6692 0 Td
(recorded)Tj
3.7984 0 Td
(up)Tj
1.2643 0 Td
(to)Tj
1.0261 0 Td
(one)Tj
1.6951 0 Td
(year)Tj
-35.0076 -1.2983 Td
(before)Tj
2.7382 0 Td
(study)Tj
2.3924 0 Td
(entry)Tj
2.3131 0 Td
(was)Tj
1.7008 0 Td
(used)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(baseline)Tj
3.4356 0 Td
(value.)Tj
2.5285 0 Td
(Patients)Tj
3.4129 0 Td
(were)Tj
2.1203 0 Td
(identified)Tj
4.0592 0 Td
(as)Tj
1.0148 0 Td
(diabetic)Tj
3.3675 0 Td
(if)Tj
0.7767 0 Td
(there)Tj
-34.401 -1.2983 Td
(was)Tj
1.6951 0 Td
(a)Tj
0.6576 0 Td
(diagnosis)Tj
3.9571 0 Td
(of)Tj
1.0148 0 Td
(diabetes)Tj
3.4639 0 Td
(at)Tj
0.9525 0 Td
(any)Tj
1.6554 0 Td
(point)Tj
2.3584 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(prior)Tj
2.2507 0 Td
(medical)Tj
3.3619 0 Td
(record,)Tj
3.0727 0 Td
(as)Tj
1.0148 0 Td
(defined)Tj
3.2258 0 Td
(previously)Tj
4.3483 0 Td
(by)Tj
-35.5348 -1.3039 Td
(Shah)Tj
2.1826 0 Td
(et)Tj
0.9411 0 Td
(al.[)Tj
0.83 0.64 0.02 0 k
(37)Tj
0 g
(])Tj
2.7609 0 Td
(Similarly,)Tj
4.0252 0 Td
(smoking)Tj
3.685 0 Td
(status)Tj
2.5002 0 Td
(was)Tj
1.7007 0 Td
(determined)Tj
4.8473 0 Td
(using)Tj
2.3924 0 Td
(the)Tj
1.4683 0 Td
(entire)Tj
2.5512 0 Td
(prior)Tj
2.2563 0 Td
(record)Tj
2.846 0 Td
(to)Tj
1.0205 0 Td
(clas-)Tj
-35.1777 -1.2982 Td
(sify)Tj
1.5873 0 Td
(patients)Tj
3.3676 0 Td
(as)Tj
1.0148 0 Td
(never-smokers,)Tj
6.3609 0 Td
(ex-smokers)Tj
4.7962 0 Td
(or)Tj
1.0998 0 Td
(current)Tj
3.1861 0 Td
(smokers)Tj
3.5603 0 Td
(at)Tj
0.9525 0 Td
(baseline.)Tj
3.6566 0 Td
(Deprivation,)Tj
-29.5821 -1.2983 Td
(divided)Tj
3.2144 0 Td
(into)Tj
1.8425 0 Td
(quintiles,)Tj
3.8891 0 Td
(was)Tj
1.7008 0 Td
(measured)Tj
4.1102 0 Td
(using)Tj
2.3868 0 Td
(the)Tj
1.4683 0 Td
(Index)Tj
2.5285 0 Td
(of)Tj
1.0148 0 Td
(Multiple)Tj
3.6397 0 Td
(Deprivation)Tj
5.0456 0 Td
(\(IMD\)[)Tj
0.83 0.64 0.02 0 k
(38)Tj
0 g
(],)Tj
4.7225 0 Td
(a)Tj
-35.5632 -1.3039 Td
(neighbourhood)Tj
6.4289 0 Td
(deprivation)Tj
4.8245 0 Td
(score)Tj
2.3017 0 Td
(combining)Tj
4.5695 0 Td
(indices)Tj
3.0273 0 Td
(of)Tj
1.0092 0 Td
(unemployment,)Tj
6.5763 0 Td
(crime,)Tj
2.7439 0 Td
(income,)Tj
3.4243 0 Td
(educa-)Tj
-34.9056 -1.2983 Td
(tion)Tj
1.8425 0 Td
(and)Tj
1.7291 0 Td
(other)Tj
2.3471 0 Td
(markers)Tj
3.4979 0 Td
(of)Tj
1.0148 0 Td
(social)Tj
2.4548 0 Td
(inequality.)Tj
-11.69 -1.2983 Td
(Our)Tj
1.8708 0 Td
(treatment)Tj
4.1329 0 Td
(variables,)Tj
3.9458 0 Td
(also)Tj
1.7688 0 Td
(obtained)Tj
3.7304 0 Td
(from)Tj
2.2053 0 Td
(CPRD,)Tj
3.0274 0 Td
([)Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
(])Tj
1.8482 0 Td
(included)Tj
3.7133 0 Td
(receipt)Tj
2.9481 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(repeat)Tj
2.6872 0 Td
(pre-)Tj
-34.7411 -1.3039 Td
(scription)Tj
3.7813 0 Td
(\(defined)Tj
3.566 0 Td
(as)Tj
1.0148 0 Td
(two)Tj
1.7064 0 Td
(or)Tj
1.0999 0 Td
(more)Tj
2.3414 0 Td
(prescriptions)Tj
5.4538 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(year)Tj
1.9049 0 Td
(prior)Tj
2.2507 0 Td
(to)Tj
1.0261 0 Td
(study)Tj
2.3924 0 Td
(entry\))Tj
2.6533 0 Td
(of)Tj
1.0148 0 Td
(statins)Tj
2.7892 0 Td
(or)Tj
-35.5008 -1.2982 Td
(blood)Tj
2.5114 0 Td
(pressure)Tj
3.5773 0 Td
(lowering)Tj
3.7361 0 Td
(medication)Tj
4.7338 0 Td
(\(thiazide)Tj
3.719 0 Td
(diuretics,)Tj
3.9118 0 Td
(beta-blockers,)Tj
5.794 0 Td
(angiotensin)Tj
4.8926 0 Td
(converting)Tj
-32.876 -1.2983 Td
(enzyme-inhibitors,)Tj
7.8008 0 Td
(angiotensin)Tj
4.8869 0 Td
(receptor)Tj
3.5547 0 Td
(blockers,)Tj
3.7814 0 Td
(or)Tj
1.0998 0 Td
(calcium-channel)Tj
6.8655 0 Td
(blockers\))Tj
3.8947 0 Td
(at)Tj
0.9525 0 Td
(baseline.)Tj
-32.8363 -1.3039 Td
(We)Tj
1.61 0 Td
(additionally)Tj
4.9776 0 Td
(included)Tj
3.7134 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(oral)Tj
1.7801 0 Td
(contraceptives)Tj
5.9698 0 Td
(or)Tj
1.0998 0 Td
(hormone)Tj
3.9231 0 Td
(replacement)Tj
5.1477 0 Td
(therapy)Tj
3.2485 0 Td
(\(HRT\))Tj
-34.0155 -1.2983 Td
(in)Tj
1.0318 0 Td
(women.)Tj
3.4299 0 Td
(Variable)Tj
3.5999 0 Td
(definitions)Tj
4.5241 0 Td
(can)Tj
1.6214 0 Td
(be)Tj
1.1509 0 Td
(found)Tj
2.6192 0 Td
(at)Tj
0.83 0.64 0.02 0 k
0.9524 0 Td
(http://www.caliberrese)Tj
9.0595 0 Td
(arch.org/portal/)Tj
0 g
(.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 429.4488 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Outcomes)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 412.4409 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(As)Tj
1.2642 0 Td
(described)Tj
4.0535 0 Td
(in)Tj
1.0318 0 Td
(previous)Tj
3.651 0 Td
(papers,[)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(])Tj
7.0526 0 Td
(our)Tj
1.627 0 Td
(primary)Tj
3.4583 0 Td
(endpoints)Tj
4.2179 0 Td
(were)Tj
2.1203 0 Td
(defined)Tj
3.2258 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(first)Tj
-34.1912 -1.2982 Td
(recorded)Tj
3.7927 0 Td
(diagnosis)Tj
3.9628 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(12)Tj
1.1679 0 Td
(most)Tj
2.2053 0 Td
(common)Tj
3.8495 0 Td
(symptomatic)Tj
5.4198 0 Td
(manifestations)Tj
6.0774 0 Td
(of)Tj
1.0148 0 Td
(CVD,)Tj
2.5342 0 Td
(irrespective)Tj
-32.5075 -1.2983 Td
(of)Tj
1.0147 0 Td
(underlying)Tj
4.5978 0 Td
(disease)Tj
3.0217 0 Td
(mechanism,)Tj
5.0683 0 Td
(arising)Tj
2.931 0 Td
(from)Tj
2.2111 0 Td
(pathology)Tj
4.1725 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(head,)Tj
2.3584 0 Td
(heart,)Tj
2.5002 0 Td
(abdomen)Tj
3.9911 0 Td
(or)Tj
1.0942 0 Td
(legs.)Tj
-35.4668 -1.2982 Td
(The)Tj
1.7801 0 Td
(first)Tj
1.8085 0 Td
(diagnosis)Tj
3.9571 0 Td
(could)Tj
2.4491 0 Td
(occur)Tj
2.4775 0 Td
(in)Tj
1.0318 0 Td
(primary)Tj
3.4583 0 Td
(care,)Tj
2.0976 0 Td
(secondary)Tj
4.2689 0 Td
(care)Tj
1.8709 0 Td
(or)Tj
1.0998 0 Td
(at)Tj
0.9525 0 Td
(death.)Tj
2.6588 0 Td
(We)Tj
1.6101 0 Td
(included)Tj
3.7077 0 Td
(the)Tj
-35.2287 -1.304 Td
(following)Tj
3.9798 0 Td
(CVDs:)Tj
2.897 0 Td
(stable)Tj
2.4888 0 Td
(angina,)Tj
3.1464 0 Td
(unstable)Tj
3.566 0 Td
(angina,)Tj
3.1407 0 Td
(non-fatal)Tj
3.8778 0 Td
(myocardial)Tj
4.7055 0 Td
(infarction)Tj
4.1726 0 Td
(\(MI\),)Tj
2.3584 0 Td
(unher-)Tj
-34.333 -1.2982 Td
(alded)Tj
2.3754 0 Td
(coronary)Tj
3.8381 0 Td
(death)Tj
2.4321 0 Td
(\(UCD\),)Tj
3.2598 0 Td
(heart)Tj
2.279 0 Td
(failure,)Tj
2.9991 0 Td
(a)Tj
0.6576 0 Td
(composite)Tj
4.3426 0 Td
(of)Tj
1.0148 0 Td
(cardiac)Tj
3.1011 0 Td
(arrest,)Tj
2.7043 0 Td
(ventricular)Tj
4.5864 0 Td
(arrhyth-)Tj
-33.5903 -1.2983 Td
(mia)Tj
1.7404 0 Td
(and)Tj
1.7291 0 Td
(sudden)Tj
3.1351 0 Td
(cardiac)Tj
3.1011 0 Td
(death)Tj
2.4321 0 Td
(\(SCD\),)Tj
2.9991 0 Td
(transient)Tj
3.77 0 Td
(ischaemic)Tj
4.1726 0 Td
(attack)Tj
2.6022 0 Td
(\(TIA\),)Tj
2.7609 0 Td
(ischaemic)Tj
4.1669 0 Td
(stroke,)Tj
-32.6095 -1.3039 Td
(subarachnoid)Tj
5.6579 0 Td
(haemorrhage)Tj
5.5218 0 Td
(\(SAH\),)Tj
3.0558 0 Td
(intracerebral)Tj
5.3347 0 Td
(haemorrhage,)Tj
5.7543 0 Td
(abdominal)Tj
4.5071 0 Td
(aortic)Tj
2.5228 0 Td
(aneurysm)Tj
-32.3544 -1.2983 Td
(\(AAA\),)Tj
3.1747 0 Td
(peripheral)Tj
4.32 0 Td
(arterial)Tj
3.0671 0 Td
(disease)Tj
3.016 0 Td
(\(PAD\),)Tj
3.1068 0 Td
(and)Tj
1.7291 0 Td
(other)Tj
2.3471 0 Td
(deaths.)Tj
3.0217 0 Td
(We)Tj
1.6044 0 Td
(combined)Tj
4.2462 0 Td
(stroke)Tj
2.6759 0 Td
(not)Tj
1.5761 0 Td
(other-)Tj
-33.8851 -1.2982 Td
(wise)Tj
1.9558 0 Td
(specified)Tj
3.7191 0 Td
(with)Tj
1.9956 0 Td
(ischaemic)Tj
4.1669 0 Td
(stroke,)Tj
2.9026 0 Td
(as)Tj
1.0148 0 Td
(previous)Tj
3.651 0 Td
(research)Tj
3.5546 0 Td
(has)Tj
1.5421 0 Td
(identified)Tj
4.0592 0 Td
(the)Tj
1.4683 0 Td
(large)Tj
2.16 0 Td
(majority)Tj
3.6283 0 Td
(of)Tj
-35.8183 -1.304 Td
(strokes)Tj
3.0387 0 Td
(are)Tj
1.4456 0 Td
(ischaemic.[)Tj
0.83 0.64 0.02 0 k
(40)Tj
0 g
(])Tj
6.0264 0 Td
(Coronary)Tj
4.0762 0 Td
(heart)Tj
2.2734 0 Td
(disease)Tj
3.0217 0 Td
(not)Tj
1.5704 0 Td
(otherwise)Tj
4.0819 0 Td
(specified)Tj
3.719 0 Td
(\(CHD)Tj
2.7269 0 Td
(NOS\))Tj
2.5228 0 Td
(was)Tj
-34.503 -1.2982 Td
(also)Tj
1.7688 0 Td
(studied)Tj
3.1521 0 Td
(but)Tj
1.5533 0 Td
(kept)Tj
1.9559 0 Td
(separate)Tj
3.481 0 Td
(from)Tj
2.2053 0 Td
(other)Tj
2.3471 0 Td
(coronary)Tj
3.8381 0 Td
(diagnoses)Tj
4.1158 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(analysis.)Tj
3.549 0 Td
(We)Tj
1.6101 0 Td
(classified)Tj
-32.0823 -1.2983 Td
(events)Tj
2.7269 0 Td
(as)Tj
1.0148 0 Td
(fatal)Tj
1.9218 0 Td
(where)Tj
2.6476 0 Td
(a)Tj
0.6576 0 Td
(death)Tj
2.4321 0 Td
(record)Tj
2.8403 0 Td
(exists)Tj
2.3981 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2564 0 Td
(calendar)Tj
3.6283 0 Td
(date.)Tj
2.1316 0 Td
(Overview)Tj
4.0422 0 Td
(of)Tj
1.0148 0 Td
(codes)Tj
2.4661 0 Td
(and)Tj
-35.0359 -1.3039 Td
(data)Tj
1.9105 0 Td
(sources)Tj
3.1974 0 Td
(used)Tj
2.058 0 Td
(to)Tj
1.0261 0 Td
(define)Tj
2.6986 0 Td
(cardiovascular)Tj
6.0037 0 Td
(endpoints)Tj
4.218 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.126 0 Td
(published)Tj
4.1215 0 Td
(previously.[)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(])Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 217.0204 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Statistical)Tj
4.4504 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 200.0125 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Descriptive)Tj
4.7621 0 Td
(statistics)Tj
3.5887 0 Td
(were)Tj
2.1259 0 Td
(used)Tj
2.058 0 Td
(to)Tj
1.0261 0 Td
(compare)Tj
3.7134 0 Td
(baseline)Tj
3.4299 0 Td
(demographic)Tj
5.5048 0 Td
(characteristics,)Tj
6.1342 0 Td
(risk)Tj
1.7121 0 Td
(factors)Tj
-34.0552 -1.3039 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(primary)Tj
3.4582 0 Td
(care)Tj
1.8709 0 Td
(consultations,)Tj
5.7713 0 Td
(and)Tj
1.7291 0 Td
(prescribed)Tj
4.4163 0 Td
(medication)Tj
4.7339 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(year)Tj
1.9049 0 Td
(prior)Tj
2.2563 0 Td
(to)Tj
-36.2775 -1.2982 Td
(entry)Tj
2.3073 0 Td
(by)Tj
1.1736 0 Td
(ethnic)Tj
2.7042 0 Td
(group.)Tj
2.8233 0 Td
(We)Tj
1.6044 0 Td
(also)Tj
1.7575 0 Td
(analysed)Tj
3.6453 0 Td
(the)Tj
1.4627 0 Td
(proportion)Tj
4.6261 0 Td
(of)Tj
1.0034 0 Td
(total)Tj
1.9956 0 Td
(CVD)Tj
2.3074 0 Td
(that)Tj
1.7745 0 Td
(individual)Tj
4.2803 0 Td
(cardiovas-)Tj
-33.4656 -1.2983 Td
(cular)Tj
2.2223 0 Td
(diagnoses)Tj
4.1159 0 Td
(comprised)Tj
4.4333 0 Td
(for)Tj
1.389 0 Td
(each)Tj
2.0296 0 Td
(ethnic)Tj
2.7099 0 Td
(group,)Tj
2.8346 0 Td
(within)Tj
2.812 0 Td
(three)Tj
2.262 0 Td
(broad)Tj
2.5682 0 Td
(age)Tj
1.542 0 Td
(bands.)Tj
2.8233 0 Td
(Continuous)Tj
-31.7421 -1.2983 Td
(variables)Tj
3.719 0 Td
(are)Tj
1.4456 0 Td
(presented)Tj
4.1159 0 Td
(as)Tj
1.0148 0 Td
(mean)Tj
2.4435 0 Td
(while)Tj
2.3697 0 Td
(categorical)Tj
4.5127 0 Td
(variables)Tj
3.7191 0 Td
(are)Tj
1.4513 0 Td
(presented)Tj
4.1159 0 Td
(as)Tj
1.0148 0 Td
(percentages;)Tj
5.1307 0 Td
(95%)Tj
-35.053 -1.3039 Td
(confidence)Tj
4.5977 0 Td
(intervals)Tj
3.6283 0 Td
(are)Tj
1.4457 0 Td
(given)Tj
2.3811 0 Td
(for)Tj
1.3833 0 Td
(all)Tj
1.1508 0 Td
(descriptive)Tj
4.5525 0 Td
(variables)Tj
3.719 0 Td
(and)Tj
1.7291 0 Td
(hazard)Tj
2.931 0 Td
(ratios,)Tj
2.6816 0 Td
(unless)Tj
2.6872 0 Td
(otherwise)Tj
-32.8873 -1.2982 Td
(stated.)Tj
1.1962 -1.2983 Td
(In)Tj
1.1111 0 Td
(primary)Tj
3.4583 0 Td
(analyses,)Tj
3.7077 0 Td
(we)Tj
1.3266 0 Td
(investigated)Tj
4.9889 0 Td
(the)Tj
1.4684 0 Td
(association)Tj
4.6261 0 Td
(of)Tj
1.0148 0 Td
(ethnic)Tj
2.7099 0 Td
(group)Tj
2.6078 0 Td
(with)Tj
2.0013 0 Td
(each)Tj
2.0239 0 Td
(CVD)Tj
2.3187 0 Td
(out-)Tj
-34.5597 -1.3039 Td
(come)Tj
2.3924 0 Td
(across)Tj
2.6759 0 Td
(all)Tj
1.1452 0 Td
(patients,)Tj
3.5943 0 Td
(using)Tj
/F11 1 Tf
2.3924 0 Td
[()11()18()14()11()]TJ
/F7 1 Tf
2.6305 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(reference)Tj
3.9174 0 Td
(group.)Tj
2.8346 0 Td
(Hazard)Tj
3.1635 0 Td
(ratios)Tj
2.4604 0 Td
(\(HRs\))Tj
2.6476 0 Td
(were)Tj
2.126 0 Td
(based)Tj
-34.4634 -1.2983 Td
(on)Tj
1.2755 0 Td
(disease-specific)Tj
6.3383 0 Td
(Cox)Tj
1.8538 0 Td
(models)Tj
3.1068 0 Td
(with)Tj
1.9955 0 Td
(length)Tj
2.7326 0 Td
(of)Tj
1.0148 0 Td
(follow-up)Tj
4.0932 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(timescale,)Tj
4.1442 0 Td
(adjusted)Tj
3.5773 0 Td
(for)Tj
1.3833 0 Td
(age)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 321.7889 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Ethnicity)Tj
3.9331 0 Td
(and)Tj
1.8567 0 Td
(the)Tj
1.5874 0 Td
(first)Tj
1.8 0 Td
(diagnosis)Tj
4.3654 0 Td
(of)Tj
1.0346 0 Td
(a)Tj
0.7654 0 Td
(wide)Tj
2.2394 0 Td
(range)Tj
2.7283 0 Td
(of)Tj
1.0418 0 Td
(cardiovasc)Tj
4.6914 0 Td
(ular)Tj
1.8567 0 Td
(diseases)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01789)Tj
4.089 0 Td
(45)Tj
0 g
2.0906 0 Td
(June)Tj
2.3528 0 Td
(9,)Tj
1.0417 0 Td
(2017)Tj
35.5113 0 Td
(4)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
118 0 obj
<>stream
endstream
endobj
119 0 obj
<>stream
endstream
endobj
120 0 obj
<>stream
endstream
endobj
121 0 obj
<>stream
endstream
endobj
122 0 obj
<>stream
endstream
endobj
123 0 obj
<>stream
endstream
endobj
124 0 obj
<>stream
endstream
endobj
125 0 obj
<>stream
endstream
endobj
126 0 obj
<>stream
endstream
endobj
127 0 obj
<>stream
BT
66.402 0 Td
(17)Tj
ET
Q
endstream
endobj
128 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 129 0 R/Contents 130 0 R/TrimBox[0 0 612 792]>>
endobj
129 0 obj
[131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R]
endobj
131 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.s001)>>
endobj
132 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref041)>>
endobj
133 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref036)>>
endobj
134 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.ref042)>>
endobj
135 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.t001)>>
endobj
136 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178945.s002)>>
endobj
137 0 obj
<>/Border[0 0 0]/A 138 0 R>>
endobj
138 0 obj
<>
endobj
130 0 obj
[139 0 R 140 0 R 141 0 R 142 0 R 143 0 R 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R]
endobj
139 0 obj
<>stream
q
0.83 0.64 0.02 0 k
200.0126 563.3008 m
251.2063 563.3008 l
h
f*
434.7213 450.5386 m
444.189 450.5386 l
h
f*
460.4598 237.9402 m
469.9843 237.9402 l
h
f*
472.1953 237.9402 m
481.7197 237.9402 l
h
f*
465.1087 172.9134 m
494.2488 172.9134 l
h
f*
513.0142 172.9134 m
546.9732 172.9134 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\(linear)Tj
2.8459 0 Td
(and)Tj
1.7291 0 Td
(quadratic)Tj
4.0139 0 Td
(term\),)Tj
2.6929 0 Td
(sex,)Tj
1.6951 0 Td
(and)Tj
1.7291 0 Td
(stratified)Tj
3.7587 0 Td
(by)Tj
1.1792 0 Td
(primary)Tj
3.4526 0 Td
(care)Tj
1.8709 0 Td
(practice.)Tj
3.6056 0 Td
(The)Tj
1.7801 0 Td
(association)Tj
4.6262 0 Td
(of)Tj
1.0148 0 Td
(eth-)Tj
-35.9941 -1.3039 Td
(nic)Tj
1.4569 0 Td
(group)Tj
2.6079 0 Td
(with)Tj
2.0013 0 Td
(the)Tj
1.4683 0 Td
(range)Tj
2.4604 0 Td
(of)Tj
1.0148 0 Td
(endpoints)Tj
4.218 0 Td
(was)Tj
1.7007 0 Td
(analysed)Tj
3.651 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.652 0 Td
(competing)Tj
4.49 0 Td
(risk)Tj
1.7178 0 Td
(framework,)Tj
4.8359 0 Td
(i.e.)Tj
1.3663 0 Td
(only)Tj
-34.6788 -1.2982 Td
(one)Tj
1.6951 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(range)Tj
2.4604 0 Td
(of)Tj
1.0148 0 Td
(diseases)Tj
3.3789 0 Td
(can)Tj
1.6271 0 Td
(be)Tj
1.1508 0 Td
(the)Tj
1.4684 0 Td
(initial)Tj
2.5455 0 Td
(diagnosis)Tj
3.9628 0 Td
(of)Tj
1.0148 0 Td
(cardiovascular)Tj
6.0037 0 Td
(disease,)Tj
3.2428 0 Td
(with)Tj
1.9956 0 Td
(other)Tj
-34.0495 -1.2983 Td
(diagnoses)Tj
4.1158 0 Td
(competing)Tj
4.4901 0 Td
(to)Tj
1.0204 0 Td
(be)Tj
1.1509 0 Td
(that)Tj
1.7802 0 Td
(first)Tj
1.8084 0 Td
(diagnosis.)Tj
4.184 0 Td
(Associations)Tj
5.2383 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4684 0 Td
(mixed/other)Tj
5.1817 0 Td
(ethnic)Tj
2.7099 0 Td
(group)Tj
-34.5314 -1.2983 Td
(were)Tj
2.1203 0 Td
(estimated)Tj
4.0761 0 Td
(but)Tj
1.5534 0 Td
(are)Tj
1.4457 0 Td
(not)Tj
1.576 0 Td
(presented.)Tj
-9.5753 -1.3039 Td
(In)Tj
1.1111 0 Td
(secondary)Tj
4.269 0 Td
(analyses,)Tj
3.7077 0 Td
(we)Tj
1.3323 0 Td
(investigated)Tj
4.9889 0 Td
(the)Tj
1.4683 0 Td
(association)Tj
4.6261 0 Td
(of)Tj
1.0148 0 Td
(ethnic)Tj
2.71 0 Td
(group)Tj
2.6078 0 Td
(after)Tj
2.0353 0 Td
(adjustment)Tj
4.7168 0 Td
(for)Tj
-35.7843 -1.2982 Td
(classical)Tj
3.4128 0 Td
(CVD)Tj
2.3188 0 Td
(risk-factors)Tj
4.7451 0 Td
(\(deprivation,)Tj
5.4028 0 Td
(smoking)Tj
3.6851 0 Td
(status,)Tj
2.7269 0 Td
(SBP,)Tj
2.0579 0 Td
(diabetes,)Tj
3.6907 0 Td
(BMI,)Tj
2.2564 0 Td
(total)Tj
2.0012 0 Td
(cholesterol,)Tj
-32.2977 -1.2983 Td
(HDL)Tj
2.262 0 Td
(cholesterol\),)Tj
5.1193 0 Td
(and)Tj
1.7291 0 Td
(baseline)Tj
3.4299 0 Td
(treatment)Tj
4.1386 0 Td
(with)Tj
1.9956 0 Td
(blood-pressure)Tj
6.2248 0 Td
(lowering)Tj
3.7304 0 Td
(medication,)Tj
4.9606 0 Td
(statins,)Tj
-33.5903 -1.3039 Td
(and)Tj
1.7291 0 Td
(female)Tj
2.8573 0 Td
(hormones.)Tj
4.507 0 Td
(We)Tj
1.6101 0 Td
(also)Tj
1.7688 0 Td
(examined)Tj
4.1272 0 Td
(modification)Tj
5.3745 0 Td
(of)Tj
1.0148 0 Td
(these)Tj
2.2563 0 Td
(associations)Tj
4.989 0 Td
(by)Tj
1.1792 0 Td
(baseline)Tj
3.4356 0 Td
(age)Tj
-34.8489 -1.2983 Td
(group)Tj
2.6078 0 Td
(and)Tj
1.7291 0 Td
(gender.)Tj
-3.1407 -1.2983 Td
(Missing)Tj
3.3845 0 Td
(values)Tj
2.6702 0 Td
(in)Tj
1.0318 0 Td
(covariates)Tj
4.1953 0 Td
(were)Tj
2.1203 0 Td
(handled)Tj
3.4582 0 Td
(using)Tj
2.3868 0 Td
(multiple)Tj
3.5659 0 Td
(imputation)Tj
4.7055 0 Td
(for)Tj
1.389 0 Td
(all)Tj
1.1452 0 Td
(analyses.)Tj
3.7077 0 Td
(\(See)Tj
0.83 0.64 0.02 0 k
-34.9566 -1.3039 Td
(S1)Tj
1.1621 0 Td
(Appendix)Tj
0 g
4.167 0 Td
(for)Tj
1.3776 0 Td
(details)Tj
2.7722 0 Td
(on)Tj
1.2643 0 Td
(our)Tj
1.6214 0 Td
(approach)Tj
3.9458 0 Td
(to)Tj
1.0148 0 Td
(imputation.\))Tj
5.2667 0 Td
(The)Tj
1.7745 0 Td
(proportional)Tj
5.3064 0 Td
(hazards)Tj
3.2825 0 Td
(assumption)Tj
-32.9553 -1.2982 Td
(was)Tj
1.6951 0 Td
(tested)Tj
2.5568 0 Td
(by)Tj
1.1792 0 Td
(plotting)Tj
3.3675 0 Td
(the)Tj
1.4684 0 Td
(Schoenfield)Tj
4.8812 0 Td
(residuals)Tj
3.7417 0 Td
(for)Tj
1.3833 0 Td
(all)Tj
1.1452 0 Td
(endpoints,)Tj
4.4447 0 Td
(comparing)Tj
4.5751 0 Td
(South)Tj
2.5568 0 Td
(Asian)Tj
2.5115 0 Td
(and)Tj
-35.5065 -1.2983 Td
(Black)Tj
2.398 0 Td
(patients)Tj
3.3676 0 Td
(to)Tj
1.0261 0 Td
(White.)Tj
2.9254 0 Td
(The)Tj
1.7858 0 Td
(assumption)Tj
4.8585 0 Td
(was)Tj
1.7008 0 Td
(met)Tj
1.7631 0 Td
(for)Tj
1.3833 0 Td
(all)Tj
1.1509 0 Td
(endpoints)Tj
4.2179 0 Td
(for)Tj
1.3833 0 Td
(all)Tj
1.1452 0 Td
(ethnic)Tj
2.7099 0 Td
(groups.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 507.5716 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Sensitivity)Tj
4.6677 0 Td
(analyses)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 490.6204 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(In)Tj
1.1055 0 Td
(sensitivity)Tj
4.2236 0 Td
(analyses,)Tj
3.7076 0 Td
(associations)Tj
4.989 0 Td
(were)Tj
2.1203 0 Td
(examined)Tj
4.1329 0 Td
(in)Tj
1.0318 0 Td
(complete)Tj
3.8834 0 Td
(cases)Tj
2.2224 0 Td
(and)Tj
1.7291 0 Td
(in)Tj
1.0375 0 Td
(analyses)Tj
3.4809 0 Td
(where)Tj
-33.664 -1.3039 Td
(we)Tj
1.3266 0 Td
(restricted)Tj
3.9854 0 Td
(endpoints)Tj
4.218 0 Td
(to)Tj
1.0261 0 Td
(those)Tj
2.3357 0 Td
(recorded)Tj
3.7984 0 Td
(in)Tj
1.0375 0 Td
(secondary)Tj
4.269 0 Td
(care)Tj
1.8708 0 Td
(and)Tj
1.7291 0 Td
(mortality)Tj
3.9175 0 Td
(data)Tj
1.9162 0 Td
(or)Tj
1.0998 0 Td
(mortality)Tj
-32.5301 -1.2982 Td
(data)Tj
1.9105 0 Td
(alone.)Tj
2.6078 0 Td
(From)Tj
2.4435 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 274.3937 469.0204 cm
BT
/F7 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(st)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 281.537 464.5984 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(April)Tj
2.3073 0 Td
(2004,)Tj
2.3471 0 Td
(primary)Tj
3.4526 0 Td
(care)Tj
1.8708 0 Td
(practices)Tj
3.7417 0 Td
(began)Tj
2.5966 0 Td
(receiving)Tj
3.8664 0 Td
(substantial)Tj
4.5014 0 Td
(financial)Tj
-32.8362 -1.2982 Td
(rewards)Tj
3.3902 0 Td
(for)Tj
1.3889 0 Td
(performance)Tj
5.3461 0 Td
(in)Tj
1.0374 0 Td
(chronic)Tj
3.2882 0 Td
(disease)Tj
3.016 0 Td
(management;)Tj
5.6636 0 Td
([)Tj
0.83 0.64 0.02 0 k
(41)Tj
0 g
(])Tj
1.8482 0 Td
(from)Tj
2.2053 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 476.6173 456.0377 cm
BT
/F7 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(st)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 483.7606 451.6157 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(April)Tj
2.3073 0 Td
(2006)Tj
2.1203 0 Td
(they)Tj
-32.8022 -1.3039 Td
(further)Tj
3.0274 0 Td
(received)Tj
3.532 0 Td
(rewards)Tj
3.3958 0 Td
(for)Tj
1.3833 0 Td
(recording)Tj
4.1273 0 Td
(ethnic)Tj
2.7099 0 Td
(group.)Tj
2.8346 0 Td
(We)Tj
1.6101 0 Td
(therefore)Tj
3.8494 0 Td
(also)Tj
1.7688 0 Td
(compared)Tj
4.2462 0 Td
(associations)Tj
-32.4848 -1.2982 Td
(between)Tj
3.5263 0 Td
(ethnic)Tj
2.7099 0 Td
(group)Tj
2.6079 0 Td
(and)Tj
1.7291 0 Td
(initial)Tj
2.5512 0 Td
(CVD)Tj
2.313 0 Td
(diagnoses)Tj
4.1159 0 Td
(before)Tj
2.7382 0 Td
(and)Tj
1.7292 0 Td
(after)Tj
2.0352 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 465.3354 430.0157 cm
BT
/F7 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(st)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 472.4787 425.5937 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(April)Tj
2.3073 0 Td
(2006.)Tj
-28.3575 -1.2982 Td
(All)Tj
1.4003 0 Td
(the)Tj
1.4684 0 Td
(analyses)Tj
3.4809 0 Td
(were)Tj
2.126 0 Td
(performed)Tj
4.4673 0 Td
(with)Tj
1.9956 0 Td
(Stata)Tj
2.16 0 Td
(12)Tj
1.1735 0 Td
(or)Tj
1.0999 0 Td
(R)Tj
0.839 0 Td
(3.0.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 381.8267 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Ethics)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 364.8188 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(study)Tj
2.3924 0 Td
(was)Tj
1.6951 0 Td
(approved)Tj
3.9742 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(Independent)Tj
5.3461 0 Td
(Scientific)Tj
3.9004 0 Td
(Advisory)Tj
3.8495 0 Td
(Committee)Tj
4.7395 0 Td
(\(ISAC\))Tj
3.067 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-34.4123 -1.3039 Td
(Medicines)Tj
4.3539 0 Td
(and)Tj
1.7292 0 Td
(Healthcare)Tj
4.5694 0 Td
(Products)Tj
3.7984 0 Td
(Regulatory)Tj
4.5694 0 Td
(Agency)Tj
3.2201 0 Td
(\(protocol)Tj
3.9345 0 Td
(12_117\))Tj
3.4356 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(MINAP)Tj
-32.8079 -1.2982 Td
(Academic)Tj
4.2235 0 Td
(Group.)Tj
3.0841 0 Td
(The)Tj
1.7802 0 Td
(study)Tj
2.3924 0 Td
(was)Tj
1.6951 0 Td
(registered)Tj
4.1556 0 Td
(at)Tj
0.9524 0 Td
(clinicaltrials.gov)Tj
6.7067 0 Td
(\(trial)Tj
2.177 0 Td
(registration)Tj
4.8302 0 Td
(NCT021)Tj
-31.9972 -1.2983 Td
(76174\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 294.9732 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 278.022 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(study)Tj
2.3924 0 Td
(cohort)Tj
2.8517 0 Td
(comprised)Tj
4.439 0 Td
(971,283)Tj
3.2995 0 Td
(White,)Tj
2.9253 0 Td
(38,292)Tj
2.8233 0 Td
(South)Tj
2.5569 0 Td
(Asian,)Tj
2.7439 0 Td
(30,896)Tj
2.8233 0 Td
(Black)Tj
2.3981 0 Td
(and)Tj
1.7291 0 Td
(27,847)Tj
-32.7626 -1.3039 Td
(Mixed/Other)Tj
5.4935 0 Td
(patients,)Tj
3.5943 0 Td
(with)Tj
1.9955 0 Td
(6,023,720,)Tj
4.2236 0 Td
(155,278,)Tj
3.5263 0 Td
(133,577)Tj
3.2995 0 Td
(and)Tj
1.7291 0 Td
(114,735)Tj
3.2996 0 Td
(person)Tj
2.948 0 Td
(years)Tj
2.2677 0 Td
(of)Tj
1.0148 0 Td
(observa-)Tj
-33.3919 -1.2982 Td
(tion)Tj
1.8425 0 Td
(respectively.)Tj
5.108 0 Td
(The)Tj
1.7801 0 Td
(ethnic)Tj
2.7099 0 Td
(group)Tj
2.6079 0 Td
(distribution)Tj
4.9719 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(cohort)Tj
2.8517 0 Td
(was)Tj
1.7007 0 Td
(broadly)Tj
3.2655 0 Td
(similar)Tj
2.9877 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
-33.3352 -1.2983 Td
(English)Tj
3.2031 0 Td
(population)Tj
4.5921 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2564 0 Td
(age)Tj
1.542 0 Td
(over)Tj
1.9786 0 Td
(the)Tj
1.4683 0 Td
(period)Tj
2.8346 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(cohort.[)Tj
0.83 0.64 0.02 0 k
(36)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(42)Tj
0 g
(])Tj
5.8903 0 Td
(A)Tj
0.9071 0 Td
(total)Tj
2.0013 0 Td
(of)Tj
1.0148 0 Td
(95,224)Tj
2.8233 0 Td
(car-)Tj
-35.4782 -1.3039 Td
(diovascular)Tj
4.7735 0 Td
(events)Tj
2.7269 0 Td
(were)Tj
2.1259 0 Td
(recorded,)Tj
4.0195 0 Td
(96.2%)Tj
2.6306 0 Td
(in)Tj
1.0318 0 Td
(White,)Tj
2.931 0 Td
(1.9%)Tj
2.1543 0 Td
(in)Tj
1.0375 0 Td
(South)Tj
2.5511 0 Td
(Asian,)Tj
2.744 0 Td
(0.9%)Tj
2.1543 0 Td
(in)Tj
1.0318 0 Td
(Black)Tj
2.4038 0 Td
(and)Tj
-34.316 -1.2983 Td
(1.1%)Tj
2.1543 0 Td
(in)Tj
1.0318 0 Td
(Mixed/Other)Tj
5.4935 0 Td
(patients.)Tj
3.5943 0 Td
(All)Tj
1.4003 0 Td
(further)Tj
3.0274 0 Td
(results)Tj
2.8063 0 Td
(are)Tj
1.4513 0 Td
(reported)Tj
3.6567 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
1.4684 0 Td
(White,)Tj
2.9253 0 Td
(South)Tj
2.5568 0 Td
(Asian)Tj
2.5172 0 Td
(and)Tj
-35.4725 -1.2982 Td
(Black)Tj
2.398 0 Td
(patients)Tj
3.3676 0 Td
(only.)Tj
-4.5694 -1.304 Td
(White)Tj
2.6985 0 Td
(patients)Tj
3.3619 0 Td
(were)Tj
2.1203 0 Td
(followed)Tj
3.6453 0 Td
(up)Tj
1.2586 0 Td
(for)Tj
1.3776 0 Td
(a)Tj
0.652 0 Td
(median)Tj
3.2315 0 Td
(of)Tj
1.0148 0 Td
(6.1)Tj
1.3889 0 Td
(years,)Tj
2.4832 0 Td
(while)Tj
2.3641 0 Td
(follow-up)Tj
4.0875 0 Td
(time)Tj
2.0239 0 Td
(was)Tj
1.6951 0 Td
(notably)Tj
-34.5994 -1.2982 Td
(shorter)Tj
3.0784 0 Td
(for)Tj
1.3889 0 Td
(South)Tj
2.5569 0 Td
(Asian)Tj
2.5114 0 Td
(\(2.6)Tj
1.7348 0 Td
(years\),)Tj
2.8347 0 Td
(and)Tj
1.7291 0 Td
(Black)Tj
2.3981 0 Td
(patients)Tj
3.3675 0 Td
(\(3.1)Tj
1.7405 0 Td
(years\).)Tj
2.8289 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.778 0 Td
(1)Tj
0 g
(;)Tj
0.9241 0 Td
(see)Tj
0.83 0.64 0.02 0 k
1.4286 0 Td
(S1)Tj
1.1679 0 Td
(Table)Tj
0 g
2.4434 0 Td
(for)Tj
-34.9112 -1.2983 Td
(baseline)Tj
3.4298 0 Td
(data)Tj
1.9163 0 Td
(by)Tj
1.1792 0 Td
(age)Tj
1.542 0 Td
(within)Tj
2.812 0 Td
(ethnic)Tj
2.7099 0 Td
(group.\))Tj
3.1747 0 Td
(Compared)Tj
4.4844 0 Td
(with)Tj
1.9956 0 Td
(White)Tj
2.7042 0 Td
(patients,)Tj
3.5943 0 Td
(South)Tj
2.5569 0 Td
(Asian)Tj
2.5115 0 Td
(and)Tj
-34.6108 -1.2983 Td
(Black)Tj
2.398 0 Td
(patients)Tj
3.3676 0 Td
(were)Tj
2.126 0 Td
(significantly)Tj
5.0853 0 Td
(younger)Tj
3.5206 0 Td
(at)Tj
0.9524 0 Td
(study)Tj
2.3868 0 Td
(entry,)Tj
2.5455 0 Td
(and)Tj
1.7291 0 Td
(were)Tj
2.1203 0 Td
(more)Tj
2.3414 0 Td
(likely)Tj
2.3584 0 Td
(to)Tj
1.0205 0 Td
(live)Tj
1.6157 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
-34.5994 -1.3039 Td
(most)Tj
2.2053 0 Td
(deprived)Tj
3.7304 0 Td
(areas.)Tj
2.4718 0 Td
(They)Tj
2.2336 0 Td
(were)Tj
2.126 0 Td
(also)Tj
1.7688 0 Td
(more)Tj
2.3414 0 Td
(likely)Tj
2.3528 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(never)Tj
2.4377 0 Td
(smokers)Tj
3.5603 0 Td
(and)Tj
1.7348 0 Td
(to)Tj
1.0205 0 Td
(have)Tj
2.0636 0 Td
(diabetes)Tj
3.4582 0 Td
(and)Tj
-35.6822 -1.2982 Td
(a)Tj
0.6519 0 Td
(statin)Tj
2.4265 0 Td
(prescription.)Tj
5.312 0 Td
(South)Tj
2.5569 0 Td
(Asian)Tj
2.5115 0 Td
(patients)Tj
3.3675 0 Td
(were)Tj
2.1203 0 Td
(less)Tj
1.6101 0 Td
(likely)Tj
2.3527 0 Td
(to)Tj
1.0205 0 Td
(be)Tj
1.1508 0 Td
(hypertensive)Tj
5.2895 0 Td
(or)Tj
1.0941 0 Td
(have)Tj
2.058 0 Td
(BP-lower-)Tj
-33.5223 -1.2983 Td
(ing)Tj
1.5023 0 Td
(medication)Tj
4.7338 0 Td
(prescribed,)Tj
4.6375 0 Td
(while)Tj
2.3697 0 Td
(Black)Tj
2.3981 0 Td
(patients)Tj
3.3676 0 Td
(were)Tj
2.1259 0 Td
(somewhat)Tj
4.2747 0 Td
(more)Tj
2.3414 0 Td
(likely)Tj
2.3527 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(hypertensive,)Tj
-32.2807 -1.3039 Td
(had)Tj
1.7064 0 Td
(lower)Tj
2.4548 0 Td
(baseline)Tj
3.4299 0 Td
(SBP)Tj
1.8368 0 Td
(and)Tj
1.7291 0 Td
(were)Tj
2.1203 0 Td
(prescribed)Tj
4.4164 0 Td
(BP)Tj
1.3549 0 Td
(medication)Tj
4.7395 0 Td
(in)Tj
1.0319 0 Td
(similar)Tj
2.9876 0 Td
(proportion)Tj
4.6318 0 Td
(to)Tj
1.0262 0 Td
(White)Tj
-33.4656 -1.2983 Td
(patients.)Tj
3.5943 0 Td
(BMI)Tj
2.0296 0 Td
(was)Tj
1.7007 0 Td
(broadly)Tj
3.2655 0 Td
(similar)Tj
2.9877 0 Td
(in)Tj
1.0375 0 Td
(all)Tj
1.1452 0 Td
(three)Tj
2.262 0 Td
(groups.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 321.7889 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Ethnicity)Tj
3.9331 0 Td
(and)Tj
1.8567 0 Td
(the)Tj
1.5874 0 Td
(first)Tj
1.8 0 Td
(diagnosis)Tj
4.3654 0 Td
(of)Tj
1.0346 0 Td
(a)Tj
0.7654 0 Td
(wide)Tj
2.2394 0 Td
(range)Tj
2.7283 0 Td
(of)Tj
1.0418 0 Td
(cardiovasc)Tj
4.6914 0 Td
(ular)Tj
1.8567 0 Td
(diseases)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01789)Tj
4.089 0 Td
(45)Tj
0 g
2.0906 0 Td
(June)Tj
2.3528 0 Td
(9,)Tj
1.0417 0 Td
(2017)Tj
35.5113 0 Td
(5)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
140 0 obj
<>stream
endstream
endobj
141 0 obj
<>stream
endstream
endobj
142 0 obj
<>stream
endstream
endobj
143 0 obj
<>stream
endstream
endobj
144 0 obj
<>stream
endstream
endobj
145 0 obj
<>stream
endstream
endobj
146 0 obj
<>stream
endstream
endobj
147 0 obj
<>stream
endstream
endobj
148 0 obj
<>stream
BT
66.402 0 Td
(17)Tj
ET
Q
endstream
endobj
149 0 obj
<>/ColorSpace<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 152 0 R/Contents 153 0 R/TrimBox[0 0 612 792]>>
endobj
150 0 obj
<>
endobj
154 0 obj
<>
endobj
155 0 obj
<>stream
%!PS-AdobeFont-1.0
%%This font is a conversion from Helvetica-Oblique with the following copyright notice:
%Copyright (c) 1985, 1987, 1989, 1990, 1997, 1998, 1999 Adobe Systems Incorporated. All Rights Reserved.Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries.
11 dict begin
/FontName /Helvetica-Oblique def
/FontType 1 def
/FontBBox {-166 -218 1114 770} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (Helvetica-Oblique) readonly def
/BaseFontName (Helvetica-Oblique) def
/Notice (Copyright \(c\) 1985, 1987, 1989, 1990, 1997, 1998, 1999 Adobe Systems Incorporated. All Rights Reserved.Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries.) readonly def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 32 /space put
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 48 /zero put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 57 /nine put
dup 58 /colon put
dup 59 /semicolon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 95 /underscore put
dup 96 /quoteleft put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
dup 161 /exclamdown put
dup 162 /cent put
dup 163 /sterling put
dup 164 /fraction put
dup 165 /yen put
dup 166 /florin put
dup 167 /section put
dup 168 /currency put
dup 169 /quotesingle put
dup 170 /quotedblleft put
dup 171 /guillemotleft put
dup 172 /guilsinglleft put
dup 173 /guilsinglright put
dup 174 /fi put
dup 175 /fl put
dup 177 /endash put
dup 178 /dagger put
dup 179 /daggerdbl put
dup 180 /periodcentered put
dup 182 /paragraph put
dup 183 /bullet put
dup 184 /quotesinglbase put
dup 185 /quotedblbase put
dup 186 /quotedblright put
dup 187 /guillemotright put
dup 188 /ellipsis put
dup 189 /perthousand put
dup 191 /questiondown put
dup 193 /grave put
dup 194 /acute put
dup 195 /circumflex put
dup 196 /tilde put
dup 197 /macron put
dup 198 /breve put
dup 199 /dotaccent put
dup 200 /dieresis put
dup 202 /ring put
dup 203 /cedilla put
dup 205 /hungarumlaut put
dup 206 /ogonek put
dup 207 /caron put
dup 208 /emdash put
dup 225 /AE put
dup 227 /ordfeminine put
dup 232 /Lslash put
dup 233 /Oslash put
dup 234 /OE put
dup 235 /ordmasculine put
dup 241 /ae put
dup 245 /dotlessi put
dup 248 /lslash put
dup 249 /oslash put
dup 250 /oe put
dup 251 /germandbls put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤)wRfxpc@X$UČc@:p:20eַl&^
ZXs/ 1# PGhjtUDA@tZ.nr[
,
"LvJLVguˏrF.Cv
\Fջo. ϛo9aѯxyNh <Іi@qlZz}g2tMag"j e,Ѥ5,[LPE5>ޤfȿB҆}_f☷?QrQYr$#h)[
Y#)793imTV9b#j2-<\ (IlUWwm5q\ѳewY j.Q5ˈZ]7{dEq"2T@cQ)Dso;_H6[l]Y6*'ɾ_I3ajJle>/:y{\M40lD/]K(09u[5