%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Gifty D. Antwi, Laura A. Bates, Rebecca King, Princess R. Mahama, Harry Tagbor, Matt Cairns, James N. Newell
Facilitators and Barriers to Uptake of an Extended Seasonal Malaria Chemoprevention Programme in Ghana: A Qualitative Study of Caregivers and Community Health Workers
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 12 0 R/Contents 13 0 R/TrimBox[0 0 612 792]>>
endobj
12 0 obj
[14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R]
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166951.ref001)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166951.ref002)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166951.ref003)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166951.ref004)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166951.ref003)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166951.ref003)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166951.ref005)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166951.ref006)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166951.ref010)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166951.ref011)>>
endobj
24 0 obj
<>/Border[0 0 0]/A 26 0 R>>
endobj
26 0 obj
<>
endobj
25 0 obj
<>/Border[0 0 0]/A 27 0 R>>
endobj
27 0 obj
<>
endobj
13 0 obj
[28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R]
endobj
28 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 591.91 m
199.9998 591.91 l
199.9998 592.41 l
575.9997 592.41 l
f*
0.83 0.64 0.02 0 k
501.8457 487.8425 m
506.6079 487.8425 l
h
f*
314.7024 461.8772 m
319.4646 461.8772 l
h
f*
278.4189 409.8898 m
283.1811 409.8898 l
h
f*
507.685 396.8504 m
512.4472 396.8504 l
h
f*
372.4157 370.885 m
377.178 370.885 l
h
f*
300.926 331.8803 m
305.6882 331.8803 l
h
f*
513.3543 318.8409 m
518.1165 318.8409 l
h
f*
325.3606 245.8772 m
330.0661 245.8772 l
h
f*
335.1118 245.8772 m
344.4661 245.8772 l
h
f*
412.5543 167.8677 m
421.852 167.8677 l
h
f*
0 g
1 j
1 J
11.4998 0 0 11.4998 200.0125 706.3937 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusion)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 689.3858 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(A)Tj
0.8832 0 Td
(combination)Tj
5.5439 0 Td
(of)Tj
1.0503 0 Td
(caregivers')Tj
4.989 0 Td
(physical)Tj
3.7894 0 Td
(access)Tj
3.3002 0 Td
(to)Tj
1.0503 0 Td
(SMC)Tj
2.4288 0 Td
(medication,)Tj
5.2754 0 Td
(the)Tj
1.5934 0 Td
(drug)Tj
2.1961 0 Td
(regimen,)Tj
4.0639 0 Td
(trust)Tj
2.1544 0 Td
(in)Tj
-38.3183 -1.474 Td
(the)Tj
1.5933 0 Td
(medical)Tj
3.6224 0 Td
(profession)Tj
4.7801 0 Td
(and)Tj
1.8678 0 Td
(perceived)Tj
4.4997 0 Td
(norms)Tj
2.9719 0 Td
(around)Tj
3.2941 0 Td
(malaria)Tj
3.4553 0 Td
(prevention)Tj
4.8338 0 Td
(all)Tj
1.1995 0 Td
(likely)Tj
2.4049 0 Td
(influenced)Tj
-34.5228 -1.468 Td
(caregivers')Tj
4.9949 0 Td
(level)Tj
2.2438 0 Td
(of)Tj
1.0444 0 Td
(uptake.)Tj
3.4672 0 Td
(SMC)Tj
2.4288 0 Td
(programmes)Tj
5.7767 0 Td
(need)Tj
2.4169 0 Td
(to)Tj
1.0443 0 Td
(consider:)Tj
4.2311 0 Td
(1\))Tj
1.098 0 Td
(developing)Tj
4.989 0 Td
(supportive,)Tj
-33.7351 -1.474 Td
(accessible)Tj
4.8278 0 Td
(and)Tj
1.8679 0 Td
(flexible)Tj
3.2822 0 Td
(modes)Tj
3.1986 0 Td
(of)Tj
1.0444 0 Td
(drug)Tj
2.1961 0 Td
(administration)Tj
6.3675 0 Td
(including)Tj
4.1057 0 Td
(home)Tj
2.6974 0 Td
(delivery)Tj
3.6164 0 Td
(and)Tj
1.8679 0 Td
(village)Tj
-35.0719 -1.474 Td
(community)Tj
5.0128 0 Td
(kiosks;)Tj
3.2464 0 Td
(2\))Tj
1.098 0 Td
(improving)Tj
4.4996 0 Td
(demand)Tj
3.7955 0 Td
(for)Tj
1.3725 0 Td
(preventive)Tj
4.7801 0 Td
(medication)Tj
5.0009 0 Td
(including)Tj
4.1058 0 Td
(the)Tj
1.5933 0 Td
(harnessing)Tj
-34.5049 -1.474 Td
(of)Tj
1.0443 0 Td
(learnt)Tj
2.6914 0 Td
(trust;)Tj
2.4229 0 Td
(and)Tj
1.8678 0 Td
(3\))Tj
1.0981 0 Td
(developing)Tj
4.989 0 Td
(community-based)Tj
8.0324 0 Td
(networks)Tj
4.1833 0 Td
(for)Tj
1.3726 0 Td
(users)Tj
2.6437 0 Td
(to)Tj
1.0443 0 Td
(support)Tj
3.5209 0 Td
(optimal)Tj
-34.9107 -1.474 Td
(uptake)Tj
3.1867 0 Td
(of)Tj
1.0443 0 Td
(SMC.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 536.9385 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
/F0 1 Tf
0 -1.4976 Td
(Background)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 501.959 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Although)Tj
4.0024 0 Td
(there)Tj
2.2621 0 Td
(is)Tj
0.8504 0 Td
(evidence)Tj
3.7133 0 Td
(of)Tj
1.0148 0 Td
(decreasing)Tj
4.4674 0 Td
(malaria)Tj
3.2258 0 Td
(morbidity)Tj
4.2349 0 Td
(and)Tj
1.7348 0 Td
(mortality)Tj
3.9175 0 Td
(globally,)Tj
3.5489 0 Td
(malaria)Tj
-32.9723 -1.3039 Td
(remains)Tj
3.4412 0 Td
(an)Tj
1.2075 0 Td
(important)Tj
4.2803 0 Td
(contributor)Tj
4.8472 0 Td
(to)Tj
1.0262 0 Td
(child)Tj
2.211 0 Td
(mortality)Tj
3.9174 0 Td
(in)Tj
1.0318 0 Td
(sub-Saharan)Tj
5.1931 0 Td
(Africa)Tj
2.6872 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.6044 0 Td
(In)Tj
1.1055 0 Td
(Ghana,)Tj
3.1068 0 Td
(it)Tj
-35.6596 -1.2982 Td
(accounts)Tj
3.7417 0 Td
(for)Tj
1.3889 0 Td
(38%)Tj
1.9276 0 Td
(of)Tj
1.0148 0 Td
(all)Tj
1.1452 0 Td
(outpatient)Tj
4.3426 0 Td
(illnesses,)Tj
3.6794 0 Td
(35%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(hospital)Tj
3.3789 0 Td
(admissions)Tj
4.6771 0 Td
(and)Tj
1.7291 0 Td
(34%)Tj
1.9276 0 Td
(of)Tj
1.0148 0 Td
(all)Tj
1.1452 0 Td
(deaths)Tj
-34.0552 -1.2983 Td
(in)Tj
1.0318 0 Td
(children)Tj
3.5602 0 Td
(under)Tj
2.6192 0 Td
(five)Tj
1.6498 0 Td
(years)Tj
2.2677 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.5987 0 Td
(Control)Tj
3.3619 0 Td
(strategies)Tj
3.9231 0 Td
(have)Tj
2.058 0 Td
(included)Tj
3.7133 0 Td
(the)Tj
1.4684 0 Td
(use)Tj
1.5363 0 Td
(of)Tj
1.0148 0 Td
(insecticide-treated)Tj
-29.8032 -1.3039 Td
(nets,)Tj
2.0692 0 Td
(indoor)Tj
2.9424 0 Td
(residual)Tj
3.3788 0 Td
(spraying,)Tj
3.8551 0 Td
(prompt)Tj
3.2485 0 Td
(diagnosis)Tj
3.9515 0 Td
(and)Tj
1.7291 0 Td
(treatment)Tj
4.1272 0 Td
(with)Tj
1.9956 0 Td
(artemisinin-based)Tj
7.4211 0 Td
(combi-)Tj
-34.7185 -1.2983 Td
(nation)Tj
2.8232 0 Td
(therapy)Tj
3.2485 0 Td
(\(ACT\))Tj
2.8573 0 Td
(and)Tj
1.7292 0 Td
(intermittent)Tj
5.0853 0 Td
(preventive)Tj
4.3993 0 Td
(treatment)Tj
4.1386 0 Td
(in)Tj
1.0318 0 Td
(pregnant)Tj
3.8267 0 Td
(women.)Tj
-27.9437 -1.2982 Td
(In)Tj
1.1111 0 Td
(2012,)Tj
2.3471 0 Td
(the)Tj
1.4683 0 Td
(World)Tj
2.8403 0 Td
(Health)Tj
2.9197 0 Td
(Organization)Tj
5.5162 0 Td
(\(WHO\))Tj
3.3845 0 Td
(recommended)Tj
6.0321 0 Td
(seasonal)Tj
3.5376 0 Td
(malaria)Tj
3.2259 0 Td
(chemo-)Tj
-33.579 -1.2983 Td
(prevention)Tj
4.575 0 Td
(\(SMC\))Tj
2.9254 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(])Tj
1.3719 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4627 0 Td
(control)Tj
3.1181 0 Td
(of)Tj
1.0091 0 Td
(malaria)Tj
3.2258 0 Td
(in)Tj
1.0318 0 Td
(children)Tj
3.549 0 Td
(under)Tj
2.6135 0 Td
(five)Tj
1.6498 0 Td
(where)Tj
2.6475 0 Td
(malaria)Tj
3.2201 0 Td
(transmis-)Tj
-33.783 -1.3039 Td
(sion)Tj
1.9048 0 Td
(is)Tj
0.8447 0 Td
(highly)Tj
2.7099 0 Td
(seasonal,)Tj
3.7588 0 Td
(primarily)Tj
3.9684 0 Td
(the)Tj
1.4684 0 Td
(Sahel)Tj
2.33 0 Td
(sub-region)Tj
4.5468 0 Td
(of)Tj
1.0148 0 Td
(sub-Saharan)Tj
5.193 0 Td
(Africa)Tj
2.6872 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
1.6044 0 Td
(SMC)Tj
2.2507 0 Td
(is)Tj
0.8448 0 Td
(the)Tj
-35.1267 -1.2983 Td
(intermittent)Tj
5.0796 0 Td
(administration)Tj
6.1738 0 Td
(of)Tj
1.0148 0 Td
(full)Tj
1.525 0 Td
(treatment)Tj
4.1386 0 Td
(courses)Tj
3.1918 0 Td
(of)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(antimalarial)Tj
5.0229 0 Td
(medicine)Tj
3.9175 0 Td
(during)Tj
2.931 0 Td
(the)Tj
-35.2117 -1.2983 Td
(malaria)Tj
3.2258 0 Td
(season)Tj
2.8516 0 Td
(to)Tj
1.0261 0 Td
(prevent)Tj
3.2598 0 Td
(malarial)Tj
3.4696 0 Td
(illness)Tj
3.0671 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(])Tj
1.3776 0 Td
(and)Tj
1.7292 0 Td
(is)Tj
0.8503 0 Td
(delivered)Tj
3.8835 0 Td
(up)Tj
1.2642 0 Td
(to)Tj
1.0262 0 Td
(four)Tj
1.9105 0 Td
(times)Tj
2.3924 0 Td
(at)Tj
0.9525 0 Td
(monthly)Tj
-32.2864 -1.3039 Td
(intervals)Tj
3.6226 0 Td
(during)Tj
2.931 0 Td
(the)Tj
1.4683 0 Td
(peak)Tj
2.092 0 Td
(malaria)Tj
3.2258 0 Td
(transmission)Tj
5.3631 0 Td
(period)Tj
2.8347 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(area.)Tj
2.1089 0 Td
(SMC)Tj
2.2507 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
2.1203 0 Td
(proven)Tj
3.0444 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
-36.1358 -1.2982 Td
(effective)Tj
3.5092 0 Td
(in)Tj
1.0375 0 Td
(reducing)Tj
3.77 0 Td
(episodes)Tj
3.6114 0 Td
(of)Tj
1.0148 0 Td
(uncomplicated)Tj
6.1851 0 Td
(malaria)Tj
3.2258 0 Td
(and)Tj
1.7291 0 Td
(severe)Tj
2.6759 0 Td
(malaria)Tj
3.2258 0 Td
(by)Tj
1.1849 0 Td
(about)Tj
2.4945 0 Td
(75%)Tj
1.9275 0 Td
(and)Tj
-35.5915 -1.2983 Td
(is)Tj
0.8447 0 Td
(cost-effective)Tj
5.4538 0 Td
(and)Tj
1.7291 0 Td
(safe)Tj
1.7235 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
1.6044 0 Td
(Its)Tj
1.2189 0 Td
(delivery)Tj
3.3902 0 Td
(by)Tj
1.1792 0 Td
(community)Tj
4.8869 0 Td
(health)Tj
2.6759 0 Td
(workers)Tj
3.4355 0 Td
(\(CHWs\))Tj
3.6567 0 Td
(has)Tj
1.542 0 Td
(been)Tj
-33.3408 -1.3039 Td
(shown)Tj
2.8459 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(feasible)Tj
3.1691 0 Td
(and)Tj
1.7291 0 Td
(to)Tj
1.0262 0 Td
(increase)Tj
3.4752 0 Td
(uptake)Tj
2.914 0 Td
(compared)Tj
4.2463 0 Td
(to)Tj
1.0261 0 Td
(clinic-based)Tj
5.0003 0 Td
(delivery)Tj
3.3846 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 289.9842 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Extended)Tj
4.3984 0 Td
(SMC)Tj
2.4237 0 Td
(programme)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 272.9763 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(To)Tj
1.3379 0 Td
(date,)Tj
2.126 0 Td
(trials)Tj
2.1996 0 Td
(of)Tj
1.0148 0 Td
(SMC)Tj
2.2507 0 Td
(have)Tj
2.0636 0 Td
(mostly)Tj
2.9027 0 Td
(been)Tj
2.126 0 Td
(conducted)Tj
4.4277 0 Td
(in)Tj
1.0318 0 Td
(places)Tj
-0.013 Tc
2.6248 0 Td
(with)Tj
1.9616 0 Td
(a)Tj
0.6463 0 Td
(short)Tj
2.2393 0 Td
(rainy)Tj
2.2507 0 Td
(season,)Tj
3.0217 0 Td
(and)Tj
-34.2252 -1.2982 Td
(there)Tj
2.2166 0 Td
(has)Tj
1.5194 0 Td
(consequently)Tj
5.3801 0 Td
(been)Tj
2.0863 0 Td
(uncertainty)Tj
4.7168 0 Td
(whether)Tj
3.4129 0 Td
(SMC)Tj
2.2224 0 Td
(might)Tj
2.5568 0 Td
(also)Tj
1.7291 0 Td
(be)Tj
1.1339 0 Td
(beneficial)Tj
3.9571 0 Td
(in)Tj
1.0205 0 Td
(areas)Tj
2.1996 0 Td
(of)Tj
0.9922 0 Td
(an)Tj
-35.1437 -1.3039 Td
(extended)Tj
3.787 0 Td
(malaria)Tj
3.1635 0 Td
(transmission)Tj
5.2554 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
3.0047 0 Td
(In)Tj
1.0941 0 Td
(response,)Tj
3.8778 0 Td
(we)Tj
1.3096 0 Td
(undertook)Tj
4.3426 0 Td
(a)Tj
0.6463 0 Td
(trial)Tj
1.7915 0 Td
(of)Tj
0.9978 0 Td
(monthly)Tj
3.5603 0 Td
(SMC)Tj
2.2224 0 Td
(over)Tj
-35.053 -1.2983 Td
(five)Tj
1.6157 0 Td
(months)Tj
3.2315 0 Td
(in)Tj
1.0148 0 Td
(an)Tj
1.1848 0 Td
(area)Tj
1.8482 0 Td
(of)Tj
0.9978 0 Td
(extended)Tj
3.7814 0 Td
(malaria)Tj
3.1634 0 Td
(transmission,)Tj
5.4765 0 Td
(in)Tj
1.0148 0 Td
(the)Tj
1.4457 0 Td
(Ashanti)Tj
3.2768 0 Td
(Region)Tj
2.9991 0 Td
(of)Tj
0.9978 0 Td
(Ghana)Tj
2.8346 0 Td
([clini-)Tj
-34.8829 -1.2983 Td
(caltrials.gov)Tj
4.8358 0 Td
(identifier:)Tj
4.0309 0 Td
(NCT01651416],)Tj
6.4799 0 Td
(a)Tj
0.6463 0 Td
(predominantly)Tj
6.0661 0 Td
(rural)Tj
2.126 0 Td
(area)Tj
1.8482 0 Td
(with)Tj
1.9615 0 Td
(moderately)Tj
4.6375 0 Td
(high)Tj
1.9729 0 Td
(malaria)Tj
-34.6051 -1.3039 Td
(transmission)Tj
5.2553 0 Td
(throughout)Tj
4.6885 0 Td
(the)Tj
1.44 0 Td
(year.)Tj
2.0863 0 Td
(Although)Tj
3.9345 0 Td
(the)Tj
1.44 0 Td
(extended)Tj
3.787 0 Td
(SMC)Tj
2.2224 0 Td
(programme)Tj
4.8699 0 Td
(reduced)Tj
3.3845 0 Td
(malaria)Tj
-33.1084 -1.2982 Td
(incidence)Tj
3.9911 0 Td
(by)Tj
1.1622 0 Td
(around)Tj
3.0841 0 Td
(40%)Tj
1.8992 0 Td
(during)Tj
2.8743 0 Td
(the)Tj
1.4457 0 Td
(rainy)Tj
2.2506 0 Td
(season,)Tj
3.0161 0 Td
(reflecting)Tj
3.8834 0 Td
(an)Tj
1.1849 0 Td
(important)Tj
4.2009 0 Td
(public)Tj
2.6532 0 Td
(health)Tj
2.6249 0 Td
(impact,)Tj
-34.2706 -1.2983 Td
(this)Tj
1.6384 0 Td
(efficacy)Tj
3.1464 0 Td
(was)Tj
1.6724 0 Td
(lower)Tj
2.4095 0 Td
(than)Tj
1.9899 0 Td
(seen)Tj
1.9445 0 Td
(elsewhere,)Tj
4.2406 0 Td
(and)Tj
1.7008 0 Td
(coverage)Tj
3.651 0 Td
(of)Tj
0.9978 0 Td
(SMC)Tj
2.2223 0 Td
(was)Tj
1.6725 0 Td
(generally)Tj
3.753 0 Td
(lower)Tj
2.4095 0 Td
(than)Tj
1.9899 0 Td
(in)Tj
-35.4385 -1.3039 Td
(countries)Tj
3.8664 0 Td
(where)Tj
2.6022 0 Td
(a)Tj
0.6463 0 Td
(shorter)Tj
3.016 0 Td
(SMC)Tj
2.228 0 Td
(programme)Tj
4.8699 0 Td
(was)Tj
1.6668 0 Td
(used)Tj
2.0239 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 139.011 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Aim)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 122.0031 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(To)Tj
1.3379 0 Td
(assess)Tj
2.5228 0 Td
(the)Tj
1.4684 0 Td
(acceptability)Tj
5.2157 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(extended)Tj
3.8551 0 Td
(SMC)Tj
2.2507 0 Td
(programme)Tj
4.9492 0 Td
(and)Tj
1.7348 0 Td
(identify)Tj
3.2939 0 Td
(facilitators)Tj
4.4163 0 Td
(and)Tj
1.7292 0 Td
(barri-)Tj
-35.2571 -1.2982 Td
(ers)Tj
1.3719 0 Td
(to)Tj
1.0261 0 Td
(caregivers')Tj
4.4334 0 Td
(uptake)Tj
2.914 0 Td
(of)Tj
1.0148 0 Td
(SMC)Tj
2.2507 0 Td
(for)Tj
1.389 0 Td
(their)Tj
2.1089 0 Td
(children,)Tj
3.7814 0 Td
(we)Tj
1.3266 0 Td
(conducted)Tj
4.4277 0 Td
(a)Tj
0.652 0 Td
(qualitative)Tj
4.3823 0 Td
(study)Tj
2.3868 0 Td
(alongside)Tj
-33.4656 -1.3039 Td
(the)Tj
1.4683 0 Td
(trial.)Tj
2.0636 0 Td
(The)Tj
1.7801 0 Td
(five)Tj
1.6555 0 Td
(objectives)Tj
4.1385 0 Td
(were)Tj
2.126 0 Td
(to)Tj
1.0261 0 Td
(understand)Tj
4.7849 0 Td
(caregivers')Tj
4.4333 0 Td
(\(i\))Tj
1.1679 0 Td
(knowledge)Tj
4.5411 0 Td
(of)Tj
1.0148 0 Td
(malaria)Tj
3.2258 0 Td
(to)Tj
1.0261 0 Td
(deter-)Tj
-34.452 -1.2983 Td
(mine)Tj
2.279 0 Td
(whether)Tj
3.4752 0 Td
(it)Tj
0.7824 0 Td
(affects)Tj
2.7383 0 Td
(uptake)Tj
2.9196 0 Td
(of)Tj
1.0148 0 Td
(SMC,)Tj
2.4775 0 Td
(and)Tj
1.7291 0 Td
(to)Tj
1.0261 0 Td
(examine)Tj
3.6 0 Td
(\(ii\))Tj
1.4343 0 Td
(perceived)Tj
4.0536 0 Td
(effect)Tj
2.364 0 Td
(of)Tj
1.0148 0 Td
(SMC)Tj
2.2507 0 Td
(on)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 273.5433 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Acceptabi)Tj
4.3157 0 Td
(lity)Tj
1.4174 0 Td
(to)Tj
1.0346 0 Td
(Caregivers)Tj
4.9678 0 Td
(of)Tj
1.0417 0 Td
(Seasonal)Tj
4.3158 0 Td
(Malaria)Tj
3.437 0 Td
(Chem)Tj
2.6221 0 Td
(oprevention)Tj
5.3504 0 Td
(Programm)Tj
4.5993 0 Td
(e)Tj
0.7653 0 Td
(in)Tj
0.978 0 Td
(Ghana)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0166)Tj
3.5434 0 Td
(951)Tj
2.6362 0 Td
(November)Tj
4.7622 0 Td
(29,)Tj
1.5874 0 Td
(2016)Tj
36.7515 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(18)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
71.4898 646.6394 m
121.663 646.6394 l
h
f*
123.2504 646.6394 m
187.7102 646.6394 l
h
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F9 1 Tf
1 TL
-0.025 Tc
0 0 Td
(be)Tj
1.1126 0 Td
(directed)Tj
3.189 0 Td
(to)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(correspond)Tj
4.2449 0 Td
(ing)Tj
1.3607 0 Td
(author)Tj
2.6291 0 Td
(\(Laura)Tj
2.6221 0 Td
(A.)Tj
-17.4757 -1.3748 Td
(Bates\).)Tj
/F8 1 Tf
0 -2.126 Td
(Funding:)Tj
/F9 1 Tf
3.5716 0 Td
(Th)Tj
1.1693 0 Td
(grant)Tj
2.1473 0 Td
(number)Tj
3.1252 0 Td
(with)Tj
1.7788 0 Td
(Department)Tj
4.5921 0 Td
(for)Tj
-16.3843 -1.3748 Td
(Internationa)Tj
4.422 0 Td
(l)Tj
0.4181 0 Td
(Developm)Tj
3.7418 0 Td
(ent)Tj
1.3748 0 Td
(is)Tj
0.8292 0 Td
(5245)Tj
2.1189 0 Td
()Tj
0.6874 0 Td
(`Delivering)Tj
-13.5922 -1.3748 Td
(effective)Tj
3.2882 0 Td
(health)Tj
2.459 0 Td
(services')Tj
3.2174 0 Td
(.)Tj
0.4464 0 Td
(Their)Tj
2.0906 0 Td
(website)Tj
2.8205 0 Td
(s)Tj
0.6449 0 Td
(can)Tj
1.5378 0 Td
(be)Tj
-16.5048 -1.3748 Td
(found)Tj
2.3669 0 Td
(here:)Tj
0.83 0.64 0.02 0 k
2.0693 0 Td
(www.dfid.gov)Tj
5.1308 0 Td
(.uk)Tj
1.3393 0 Td
(http://r4d.dfi)Tj
4.5922 0 Td
(d.gov.uk/)Tj
0 g
-15.4985 -1.3748 Td
(.)Tj
0.4464 0 Td
(COMDIS)Tj
3.2315 0 Td
(-HSD)Tj
2.2323 0 Td
(received)Tj
3.2953 0 Td
(the)Tj
1.3748 0 Td
(funding.)Tj
3.2599 0 Td
(The)Tj
1.5874 0 Td
(funders)Tj
-15.4276 -1.3748 Td
(had)Tj
1.5874 0 Td
(no)Tj
1.1693 0 Td
(role)Tj
1.6157 0 Td
(in)Tj
0.8859 0 Td
(study)Tj
2.2606 0 Td
(design,)Tj
2.9055 0 Td
(data)Tj
1.793 0 Td
(collecti)Tj
2.5653 0 Td
(on)Tj
1.1693 0 Td
(and)Tj
-15.952 -1.3748 Td
(analysis,)Tj
3.4086 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
0.9497 0 Td
(publish,)Tj
3.1393 0 Td
(or)Tj
1.0064 0 Td
(prepara)Tj
2.8205 0 Td
(tion)Tj
1.6157 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-17.1851 -1.3749 Td
(manuscript.)Tj
/F8 1 Tf
0 -2.126 Td
(Competing)Tj
4.3795 0 Td
(Interests)Tj
3.3307 0 Td
(:)Tj
/F9 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
29 0 obj
<>stream
endstream
endobj
30 0 obj
<>stream
endstream
endobj
31 0 obj
<>stream
endstream
endobj
32 0 obj
<>stream
endstream
endobj
33 0 obj
<>stream
endstream
endobj
34 0 obj
<>stream
endstream
endobj
35 0 obj
<>stream
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
BT
10.3394 -16.6253 Td
(exist.)Tj
ET
Q
endstream
endobj
41 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 42 0 R/Contents 43 0 R/TrimBox[0 0 612 792]>>
endobj
42 0 obj
[44 0 R 45 0 R]
endobj
44 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166951.ref001)>>
endobj
45 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166951.t001)>>
endobj
43 0 obj
[46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R]
endobj
46 0 obj
<>stream
q
0.83 0.64 0.02 0 k
536.5984 580.1386 m
541.3606 580.1386 l
h
f*
260.5606 164.126 m
289.7575 164.126 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(children's)Tj
4.1328 0 Td
(health,)Tj
2.9027 0 Td
(\(iii\))Tj
1.7008 0 Td
(experiences)Tj
4.8642 0 Td
(and)Tj
1.7348 0 Td
(attitudes)Tj
3.651 0 Td
(concerning)Tj
4.7508 0 Td
(the)Tj
1.4684 0 Td
(concept)Tj
3.3618 0 Td
(of)Tj
1.0148 0 Td
(SMC,)Tj
2.4775 0 Td
(\(iv\))Tj
1.6214 0 Td
(experi-)Tj
-33.681 -1.3039 Td
(ences)Tj
2.398 0 Td
(and)Tj
1.7292 0 Td
(attitudes)Tj
3.6566 0 Td
(concerning)Tj
4.7509 0 Td
(the)Tj
1.4683 0 Td
(regimen)Tj
3.5376 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(chemoprevention)Tj
7.285 0 Td
(and)Tj
1.7291 0 Td
(in)Tj
1.0318 0 Td
(particular)Tj
4.1159 0 Td
(the)Tj
-34.1856 -1.2982 Td
(extended)Tj
3.855 0 Td
(period)Tj
2.8347 0 Td
(of)Tj
1.0148 0 Td
(SMC)Tj
2.2507 0 Td
(delivery,)Tj
3.6169 0 Td
(and)Tj
1.7292 0 Td
(\(v\))Tj
1.3549 0 Td
(preferred)Tj
3.9402 0 Td
(place)Tj
2.262 0 Td
(of)Tj
1.0148 0 Td
(administration)Tj
6.1681 0 Td
(of)Tj
1.0148 0 Td
(SMC.)Tj
2.4775 0 Td
(We)Tj
1.6101 0 Td
(were)Tj
-35.1437 -1.2983 Td
(particularly)Tj
4.8131 0 Td
(interested)Tj
4.1613 0 Td
(in)Tj
1.0375 0 Td
(factors)Tj
2.9026 0 Td
(that)Tj
1.7745 0 Td
(may)Tj
1.9275 0 Td
(have)Tj
2.0636 0 Td
(facilitated)Tj
4.1273 0 Td
(caregivers)Tj
4.2122 0 Td
(accepting)Tj
4.0252 0 Td
(at)Tj
0.9524 0 Td
(least)Tj
1.9786 0 Td
(four)Tj
1.9162 0 Td
(of)Tj
-35.892 -1.2983 Td
(the)Tj
1.4683 0 Td
(five)Tj
1.6554 0 Td
(SMC)Tj
2.2507 0 Td
(doses)Tj
2.3981 0 Td
(\(termed)Tj
3.4242 0 Td
(optimal)Tj
3.3109 0 Td
(uptake\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 629.1779 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Method)Tj
/F0 1 Tf
0 -1.4976 Td
(Study)Tj
2.7543 0 Td
(setting)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 594.1984 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(randomised)Tj
5.0059 0 Td
(controlled)Tj
4.32 0 Td
(trial)Tj
1.8369 0 Td
(\(RCT\))Tj
2.8006 0 Td
(was)Tj
1.6951 0 Td
(conducted)Tj
4.4277 0 Td
(in)Tj
1.0374 0 Td
(all)Tj
1.1452 0 Td
(13)Tj
1.1736 0 Td
(communities)Tj
5.4821 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(Kwaso)Tj
-33.1878 -1.2982 Td
(sub-municipality)Tj
7.0355 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(Ejisu-Juaben)Tj
5.3235 0 Td
(Municipality)Tj
5.3631 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(Ashanti)Tj
3.3392 0 Td
(Region)Tj
3.05 0 Td
(of)Tj
1.0148 0 Td
(Ghana)Tj
2.88 0 Td
(\([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.9446 0 Td
(Chil-)Tj
-34.9226 -1.3039 Td
(dren)Tj
2.0919 0 Td
(aged)Tj
2.0693 0 Td
(between)Tj
3.5263 0 Td
(three)Tj
2.2677 0 Td
(months)Tj
3.2825 0 Td
(and)Tj
1.7291 0 Td
(five)Tj
1.6497 0 Td
(years)Tj
2.2677 0 Td
(in)Tj
1.0375 0 Td
(July)Tj
1.7745 0 Td
(2012,)Tj
2.3471 0 Td
(living)Tj
2.4718 0 Td
(in)Tj
1.0374 0 Td
(study)Tj
2.3868 0 Td
(communities)Tj
-29.9393 -1.2983 Td
(already)Tj
3.1124 0 Td
(providing)Tj
4.1442 0 Td
(home-based)Tj
5.1023 0 Td
(management)Tj
5.4312 0 Td
(of)Tj
1.0148 0 Td
(malaria)Tj
3.2258 0 Td
(\(HMM\))Tj
3.4582 0 Td
(were)Tj
2.1203 0 Td
(enrolled)Tj
3.515 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(study.)Tj
-33.63 -1.2983 Td
(Between)Tj
3.5943 0 Td
(July)Tj
1.7688 0 Td
(and)Tj
1.7178 0 Td
(November)Tj
4.456 0 Td
(2012,)Tj
2.3414 0 Td
(children)Tj
3.5489 0 Td
(were)Tj
2.109 0 Td
(given)Tj
2.3754 0 Td
(either)Tj
2.5228 0 Td
(five)Tj
1.6441 0 Td
(monthly)Tj
3.6113 0 Td
(SMC)Tj
2.2451 0 Td
(cycles)Tj
2.5455 0 Td
(consist-)Tj
-34.4804 -1.3039 Td
(ing)Tj
1.5023 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(single)Tj
2.5285 0 Td
(dose)Tj
2.0409 0 Td
(of)Tj
1.0148 0 Td
(sulfadoxine-pyrimethamin)Tj
10.6979 0 Td
(e)Tj
0.6406 0 Td
(plus)Tj
1.8708 0 Td
(amodiaquine)Tj
5.4879 0 Td
(given)Tj
2.3754 0 Td
(over)Tj
1.9786 0 Td
(three)Tj
2.262 0 Td
(days,)Tj
2.2224 0 Td
(or)Tj
-36.2889 -1.2982 Td
(matching)Tj
4.0024 0 Td
(placebos.)Tj
3.8665 0 Td
(During)Tj
3.1351 0 Td
(the)Tj
1.4683 0 Td
(first)Tj
1.8085 0 Td
(day)Tj
1.6328 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4741 0 Td
(first)Tj
1.8028 0 Td
(study)Tj
2.3924 0 Td
(month,)Tj
3.1464 0 Td
(the)Tj
1.4684 0 Td
(field)Tj
1.9729 0 Td
(team)Tj
2.194 0 Td
(and)Tj
1.7291 0 Td
(CHWs)Tj
-33.1084 -1.2983 Td
(held)Tj
1.9445 0 Td
(a)Tj
0.652 0 Td
(community)Tj
4.8869 0 Td
(gathering)Tj
4.0195 0 Td
(to)Tj
1.0261 0 Td
(recruit)Tj
2.9027 0 Td
(children)Tj
3.5546 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.474 0 Td
(study)Tj
2.3868 0 Td
(and)Tj
1.7291 0 Td
(administer)Tj
4.5411 0 Td
(the)Tj
1.4683 0 Td
(first)Tj
1.8085 0 Td
(of)Tj
1.0148 0 Td
(three)Tj
-34.435 -1.2983 Td
(daily)Tj
2.1486 0 Td
(doses)Tj
2.3981 0 Td
(of)Tj
1.0148 0 Td
(SMC.)Tj
2.4775 0 Td
(Caregivers)Tj
4.456 0 Td
(were)Tj
2.1203 0 Td
(required)Tj
3.6397 0 Td
(to)Tj
1.0261 0 Td
(self-administer)Tj
6.2078 0 Td
(the)Tj
1.4684 0 Td
(remaining)Tj
4.3653 0 Td
(doses)Tj
2.4038 0 Td
(of)Tj
1.0147 0 Td
(amo-)Tj
-34.7411 -1.3039 Td
(diaquine)Tj
3.719 0 Td
(to)Tj
1.0261 0 Td
(their)Tj
2.109 0 Td
(children)Tj
3.5546 0 Td
(over)Tj
1.9786 0 Td
(the)Tj
1.4683 0 Td
(following)Tj
3.9798 0 Td
(two)Tj
1.7121 0 Td
(consecutive)Tj
4.8756 0 Td
(days.)Tj
2.2224 0 Td
(Over)Tj
2.2166 0 Td
(the)Tj
1.4684 0 Td
(remaining)Tj
4.3653 0 Td
(four)Tj
-34.6958 -1.2983 Td
(subsequent)Tj
4.7054 0 Td
(months)Tj
3.2825 0 Td
(the)Tj
1.4684 0 Td
(study)Tj
2.3867 0 Td
(team)Tj
2.1997 0 Td
(and)Tj
1.7291 0 Td
(CHWs)Tj
2.9764 0 Td
(repeated)Tj
3.6396 0 Td
(this)Tj
1.6725 0 Td
(process)Tj
3.1861 0 Td
(of)Tj
1.0148 0 Td
(SMC)Tj
2.2507 0 Td
(administration.)Tj
-30.5119 -1.2982 Td
(However,)Tj
4.0761 0 Td
(for)Tj
1.3833 0 Td
(children)Tj
3.5603 0 Td
(whose)Tj
2.7213 0 Td
(carers)Tj
2.6022 0 Td
(did)Tj
1.5477 0 Td
(not)Tj
1.5704 0 Td
(attend)Tj
2.7495 0 Td
(a)Tj
0.6577 0 Td
(community)Tj
4.8869 0 Td
(gathering)Tj
4.0195 0 Td
(\(fourth)Tj
3.0784 0 Td
(month)Tj
-32.8533 -1.3039 Td
(onwards\),)Tj
4.2179 0 Td
(CHWs)Tj
2.9763 0 Td
(visited)Tj
2.8177 0 Td
(children)Tj
3.5602 0 Td
(at)Tj
0.9525 0 Td
(home)Tj
2.4945 0 Td
(to)Tj
1.0261 0 Td
(deliver)Tj
2.9367 0 Td
(the)Tj
1.4683 0 Td
(first)Tj
1.8028 0 Td
(daily)Tj
2.1543 0 Td
(dose.)Tj
2.2621 0 Td
(CHWs)Tj
2.9763 0 Td
(also)Tj
1.7688 0 Td
(visited)Tj
2.8177 0 Td
(the)Tj
-36.2322 -1.2983 Td
(children)Tj
3.5546 0 Td
(each)Tj
2.0296 0 Td
(month)Tj
2.9196 0 Td
(after)Tj
2.0353 0 Td
(day)Tj
1.6384 0 Td
(three)Tj
2.262 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(dosing)Tj
2.897 0 Td
(regimen)Tj
3.5433 0 Td
(to)Tj
1.0204 0 Td
(record)Tj
2.846 0 Td
(any)Tj
1.6554 0 Td
(side-effects.)Tj
-27.6886 -1.2983 Td
(CHWs)Tj
2.982 0 Td
(supported)Tj
4.2689 0 Td
(many)Tj
2.4775 0 Td
(health)Tj
2.6759 0 Td
(activities)Tj
3.7134 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(community,)Tj
5.1136 0 Td
(such)Tj
2.058 0 Td
(as)Tj
1.0148 0 Td
(monthly)Tj
3.6226 0 Td
(child)Tj
2.2167 0 Td
(welfare)Tj
-33.8454 -1.3039 Td
(clinics,)Tj
2.982 0 Td
(national)Tj
3.5036 0 Td
(immunization)Tj
5.9357 0 Td
(days,)Tj
2.2223 0 Td
(and)Tj
1.7292 0 Td
(administration)Tj
6.1738 0 Td
(of)Tj
1.0148 0 Td
(oral)Tj
1.7745 0 Td
(rehydration)Tj
4.9549 0 Td
(sachets)Tj
3.05 0 Td
(for)Tj
1.3833 0 Td
(chil-)Tj
-34.7241 -1.2982 Td
(dren)Tj
2.0919 0 Td
(with)Tj
1.9956 0 Td
(diarrhoea,)Tj
4.3086 0 Td
(supervised)Tj
4.4561 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(health)Tj
2.6816 0 Td
(directorate)Tj
4.5637 0 Td
(of)Tj
1.0148 0 Td
(their)Tj
2.109 0 Td
(district.)Tj
3.2598 0 Td
(CHWs)Tj
2.9763 0 Td
(are)Tj
1.4514 0 Td
(known)Tj
3.0047 0 Td
(to)Tj
-36.561 -1.2983 Td
(the)Tj
1.4683 0 Td
(study)Tj
2.3867 0 Td
(communities)Tj
5.4879 0 Td
(through)Tj
3.4412 0 Td
(a)Tj
0.6577 0 Td
(Home)Tj
2.7382 0 Td
(Management)Tj
5.5049 0 Td
(of)Tj
1.0147 0 Td
(Malaria)Tj
3.2996 0 Td
(\(the)Tj
1.8084 0 Td
(HMM)Tj
2.7723 0 Td
(programme)Tj
-30.5799 -1.2983 Td
(established)Tj
4.5977 0 Td
(in)Tj
1.0318 0 Td
(2007.)Tj
2.3471 0 Td
(CHWs)Tj
2.982 0 Td
(within)Tj
2.812 0 Td
(the)Tj
1.4683 0 Td
(HMM)Tj
2.7723 0 Td
(programme)Tj
4.9492 0 Td
(are)Tj
1.4514 0 Td
(based)Tj
2.4718 0 Td
(at)Tj
0.9524 0 Td
(home,)Tj
2.7212 0 Td
(or)Tj
1.0999 0 Td
(at)Tj
0.9524 0 Td
(a)Tj
0.652 0 Td
(known)Tj
-33.2615 -1.3039 Td
(location)Tj
3.4525 0 Td
(in)Tj
1.0318 0 Td
(their)Tj
2.109 0 Td
(village.)Tj
2.982 0 Td
(Using)Tj
2.5965 0 Td
(a)Tj
0.6577 0 Td
(standard)Tj
3.719 0 Td
(algorithm)Tj
4.1612 0 Td
(the)Tj
1.4684 0 Td
(CHWs)Tj
2.9763 0 Td
(manage)Tj
3.3449 0 Td
(children)Tj
3.5546 0 Td
(seeking)Tj
3.2088 0 Td
(treat-)Tj
-35.2627 -1.2983 Td
(ment)Tj
2.3073 0 Td
(for)Tj
1.389 0 Td
(fevers,)Tj
2.7666 0 Td
(or)Tj
1.0998 0 Td
(other)Tj
2.3471 0 Td
(symptoms,)Tj
4.5808 0 Td
(by)Tj
1.1848 0 Td
(immediate)Tj
4.5014 0 Td
(referral)Tj
3.1465 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(health)Tj
2.6815 0 Td
(facility)Tj
2.897 0 Td
(or)Tj
1.0999 0 Td
(treated)Tj
2.9933 0 Td
(pre-)Tj
-34.6731 -1.2982 Td
(sumptively)Tj
4.5864 0 Td
(with)Tj
2.0012 0 Td
(artesunate-amodiaquine.)Tj
10.1763 0 Td
(Recently,)Tj
3.8891 0 Td
(rapid)Tj
2.3358 0 Td
(diagnostic)Tj
4.32 0 Td
(tests)Tj
1.9615 0 Td
(\(RDTs\))Tj
3.2315 0 Td
(were)Tj
-32.5018 -1.3039 Td
(introduced)Tj
4.6431 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(HMM)Tj
2.7723 0 Td
(programme,)Tj
5.176 0 Td
(and)Tj
1.7292 0 Td
(case-management)Tj
7.4267 0 Td
(of)Tj
1.0148 0 Td
(confirmed)Tj
4.3937 0 Td
(malaria)Tj
3.2258 0 Td
(cases)Tj
2.2223 0 Td
(is)Tj
-35.0983 -1.2983 Td
(with)Tj
1.9955 0 Td
(artemether-lumefantr)Tj
8.7023 0 Td
(ine)Tj
1.457 0 Td
(\(AL\).)Tj
2.3471 0 Td
(Children)Tj
3.7984 0 Td
(with)Tj
1.9956 0 Td
(negative)Tj
3.5319 0 Td
(tests)Tj
1.9616 0 Td
(are)Tj
1.4513 0 Td
(referred)Tj
3.4186 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(health)Tj
2.6815 0 Td
(cen-)Tj
-35.8353 -1.2983 Td
(tre)Tj
1.3095 0 Td
(for)Tj
1.389 0 Td
(further)Tj
3.0274 0 Td
(management.)Tj
5.6579 0 Td
(No)Tj
1.4684 0 Td
(conditions)Tj
4.473 0 Td
(other)Tj
2.3471 0 Td
(than)Tj
2.0296 0 Td
(malaria)Tj
3.2258 0 Td
(were)Tj
2.1203 0 Td
(treated)Tj
2.999 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.474 0 Td
(CHW)Tj
2.6135 0 Td
(dur-)Tj
-35.3137 -1.3039 Td
(ing)Tj
1.5023 0 Td
(the)Tj
1.4683 0 Td
(trial)Tj
1.8369 0 Td
(period;)Tj
3.0557 0 Td
(children)Tj
3.5603 0 Td
(with)Tj
1.9956 0 Td
(signs)Tj
2.2223 0 Td
(of)Tj
1.0148 0 Td
(severe)Tj
2.6759 0 Td
(disease)Tj
3.0217 0 Td
(or)Tj
1.0942 0 Td
(where)Tj
2.6532 0 Td
(malaria)Tj
3.2258 0 Td
(was)Tj
1.6951 0 Td
(excluded)Tj
3.7871 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
-35.824 -1.2983 Td
(cause)Tj
2.3867 0 Td
(of)Tj
1.0148 0 Td
(illness)Tj
2.6759 0 Td
(were)Tj
2.1203 0 Td
(referred)Tj
3.4242 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(health)Tj
2.6759 0 Td
(facility.)Tj
-15.5961 -1.2982 Td
(The)Tj
1.7858 0 Td
(13)Tj
1.1678 0 Td
(communities)Tj
5.4879 0 Td
(were)Tj
2.1203 0 Td
(divided)Tj
3.2145 0 Td
(into)Tj
1.8425 0 Td
(three)Tj
2.262 0 Td
(groups)Tj
2.9707 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(qualitative)Tj
4.3767 0 Td
(study:)Tj
2.6135 0 Td
(peri-urban)Tj
-31.8952 -1.3039 Td
(communities)Tj
5.4821 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6576 0 Td
(health)Tj
2.6759 0 Td
(care)Tj
1.8709 0 Td
(facility)Tj
2.897 0 Td
(\(HCF\),)Tj
3.084 0 Td
(peri-urban)Tj
4.5411 0 Td
(communities)Tj
5.4822 0 Td
(with)Tj
1.9956 0 Td
(no)Tj
1.2755 0 Td
(HCF)Tj
2.1827 0 Td
(and)Tj
-34.1402 -1.2983 Td
(rural)Tj
2.1713 0 Td
(communities)Tj
5.4821 0 Td
(with)Tj
1.9956 0 Td
(no)Tj
1.2756 0 Td
(HCF.)Tj
2.4038 0 Td
(Two)Tj
2.0239 0 Td
(communities)Tj
5.4822 0 Td
(per)Tj
1.5307 0 Td
(group)Tj
2.6078 0 Td
(were)Tj
2.126 0 Td
(randomly)Tj
4.1272 0 Td
(selected)Tj
3.3505 0 Td
(for)Tj
-34.5767 -1.2983 Td
(inclusion)Tj
3.9174 0 Td
(into)Tj
1.8368 0 Td
(the)Tj
1.4741 0 Td
(qualitative)Tj
4.3766 0 Td
(study.)Tj
2.6135 0 Td
(In-depth)Tj
3.7531 0 Td
(interviews)Tj
4.32 0 Td
(\(IDIs\))Tj
2.6759 0 Td
(with)Tj
2.0012 0 Td
(caregivers)Tj
4.2123 0 Td
(of)Tj
1.0148 0 Td
(children)Tj
3.5546 0 Td
(who)Tj
-35.7503 -1.2982 Td
(had)Tj
1.7064 0 Td
(received)Tj
3.5376 0 Td
(the)Tj
1.4683 0 Td
(active)Tj
2.5229 0 Td
(SMC,)Tj
2.4774 0 Td
(and)Tj
1.7292 0 Td
(focus)Tj
2.3243 0 Td
(group)Tj
2.6079 0 Td
(discussions)Tj
4.7338 0 Td
(\(FGDs\))Tj
3.2429 0 Td
(with)Tj
1.9955 0 Td
(caregivers)Tj
4.218 0 Td
(of)Tj
1.0148 0 Td
(children)Tj
-33.579 -1.3039 Td
(who)Tj
1.9388 0 Td
(had)Tj
1.7065 0 Td
(received)Tj
3.5376 0 Td
(both)Tj
2.0579 0 Td
(active)Tj
2.5229 0 Td
(SMC)Tj
2.2506 0 Td
(and)Tj
1.7292 0 Td
(placebo,)Tj
3.5036 0 Td
(took)Tj
2.0296 0 Td
(place)Tj
2.262 0 Td
(after)Tj
2.0353 0 Td
(the)Tj
1.474 0 Td
(administration)Tj
6.1681 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(fifth)Tj
-35.6993 -1.2983 Td
(SMC)Tj
2.2506 0 Td
(dose)Tj
2.041 0 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7631 0 Td
(Table)Tj
2.4435 0 Td
(1)Tj
0 g
(\).)Tj
1.2642 0 Td
(All)Tj
1.3946 0 Td
(participants)Tj
4.955 0 Td
(were)Tj
2.1259 0 Td
(female.)Tj
3.0785 0 Td
(Caregivers)Tj
4.456 0 Td
(of)Tj
1.0148 0 Td
(children)Tj
3.5546 0 Td
(enrolled)Tj
3.5149 0 Td
(into)Tj
1.8426 0 Td
(the)Tj
-35.6993 -1.2983 Td
(SMC)Tj
2.2506 0 Td
(trial)Tj
1.8369 0 Td
(were)Tj
2.1203 0 Td
(predominantly)Tj
6.1851 0 Td
(of)Tj
1.0148 0 Td
(Ashanti)Tj
3.3392 0 Td
(ethnicity)Tj
3.7304 0 Td
(\(the)Tj
1.8085 0 Td
(remainder)Tj
4.4107 0 Td
(being)Tj
2.4321 0 Td
(of)Tj
1.0148 0 Td
(Ewe,)Tj
2.1203 0 Td
(Grumani)Tj
-32.2637 -1.3039 Td
(and)Tj
1.7291 0 Td
(Grushi)Tj
2.9877 0 Td
(ethnicity\))Tj
4.0705 0 Td
(and)Tj
1.7291 0 Td
(of)Tj
1.0148 0 Td
(Muslim)Tj
3.3392 0 Td
(or)Tj
1.0942 0 Td
(Christian)Tj
3.9571 0 Td
(faith.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 112.9889 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Recruitment)Tj
5.5512 0 Td
(and)Tj
1.8661 0 Td
(sampling)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 95.9811 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Uptake)Tj
3.1237 0 Td
(was)Tj
1.7008 0 Td
(categorised)Tj
4.7225 0 Td
(into)Tj
1.8368 0 Td
(those)Tj
2.3414 0 Td
(participants)Tj
4.9549 0 Td
(who)Tj
1.9389 0 Td
(received)Tj
3.5376 0 Td
(at)Tj
0.9525 0 Td
(least)Tj
1.9842 0 Td
(four)Tj
1.9106 0 Td
(cycles)Tj
2.5511 0 Td
(of)Tj
1.0148 0 Td
(SMC)Tj
2.2564 0 Td
(\(here-)Tj
-34.8262 -1.2982 Td
(after)Tj
2.0352 0 Td
(`optimal')Tj
3.7474 0 Td
(uptake,)Tj
3.1464 0 Td
(even)Tj
2.0693 0 Td
(though)Tj
3.0727 0 Td
(it)Tj
0.7824 0 Td
(is)Tj
0.8504 0 Td
(not)Tj
1.576 0 Td
(ideal)Tj
2.1147 0 Td
(for)Tj
1.3889 0 Td
(children)Tj
3.5547 0 Td
(to)Tj
1.0261 0 Td
(miss)Tj
2.0296 0 Td
(any)Tj
1.6554 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(monthly)Tj
3.6227 0 Td
(SMC)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 273.5433 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Acceptabi)Tj
4.3157 0 Td
(lity)Tj
1.4174 0 Td
(to)Tj
1.0346 0 Td
(Caregivers)Tj
4.9678 0 Td
(of)Tj
1.0417 0 Td
(Seasonal)Tj
4.3158 0 Td
(Malaria)Tj
3.437 0 Td
(Chem)Tj
2.6221 0 Td
(oprevention)Tj
5.3504 0 Td
(Programm)Tj
4.5993 0 Td
(e)Tj
0.7653 0 Td
(in)Tj
0.978 0 Td
(Ghana)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0166)Tj
3.5434 0 Td
(951)Tj
2.6362 0 Td
(November)Tj
4.7622 0 Td
(29,)Tj
1.5874 0 Td
(2016)Tj
36.7515 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
BT
66.402 0 Td
(18)Tj
ET
Q
endstream
endobj
52 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 54 0 R/Contents 55 0 R/TrimBox[0 0 612 792]>>
endobj
53 0 obj
<>
endobj
56 0 obj
<>
endobj
57 0 obj
<>stream
%!PS-AdobeFont-1.0
11 dict begin
/FontName /TeX_CM_Maths_Symbols def
/FontType 1 def
/FontBBox {-20 -958 1114 770} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (TeX_CM_Maths_Symbols) readonly def
/BaseFontName (TeX_CM_Maths_Symbols) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 0 /C0 put
dup 1 /C1 put
dup 2 /C2 put
dup 3 /C3 put
dup 4 /C4 put
dup 5 /C5 put
dup 6 /C6 put
dup 7 /C7 put
dup 8 /C8 put
dup 9 /C9 put
dup 10 /C10 put
dup 11 /C11 put
dup 12 /C12 put
dup 13 /C13 put
dup 14 /C14 put
dup 15 /C15 put
dup 16 /C16 put
dup 17 /C17 put
dup 18 /C18 put
dup 19 /C19 put
dup 20 /C20 put
dup 21 /C21 put
dup 22 /C22 put
dup 23 /C23 put
dup 24 /C24 put
dup 25 /C25 put
dup 26 /C26 put
dup 27 /C27 put
dup 28 /C28 put
dup 29 /C29 put
dup 30 /C30 put
dup 31 /C31 put
dup 32 /space put
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 48 /zero put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 57 /nine put
dup 58 /colon put
dup 59 /semicolon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 95 /underscore put
dup 96 /quoteleft put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
dup 127 /Euro put
dup 128 /ff put
dup 129 /ffi put
dup 130 /ffl put
dup 131 /C131 put
dup 132 /Eth put
dup 133 /eth put
dup 134 /Thorn put
dup 135 /thorn put
dup 136 /onequarter put
dup 137 /onehalf put
dup 138 /C138 put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤(HwK7X7
Mr:E%]3<Ӝ$wrAQ4ADt%̏>E hAجm*pu@>#6aZi}NRmƼ%
,OgX' EX?ڞ\#JEG<IXS}Eh[ş8ї48ٶ.w4bJ?_nfulqD?둓\C%+' { L9K7isW+ӕ(6oɧVҺlS;5K
Z%.oQՕW*9Qk_S+B-}%lYC@WP0b\KKdi>t,n_S[ '9`-z+cڦEb#c@;yɸoAT O_H~i -6ϰ豟Ae&BF+
wNX!=hhUF8(hZ6pgJc m'9dx*^wXc
գ<.쯶c ln)/LvXY2jbF:ȸ3'>\Ȥmzj,!:ZK' (q/ -&&S ؤ-bm KQSxLGu `D3yԱKaVMU§ %iq5%s 2SdR#ho45H.4TdՊa<K>BqG- Ao, (e&F2gG`z8*༠&
x#B
B;8!93~T/ \>nLazCSKm~,!_<ӾX@X@N2vEt בFmBYa wRG[i;+oM+%(8 jԀlIW>t