Items where authors include "Meakin, PJ"

Article

Taylor, HA orcid.org/0000-0003-3592-1857, Przemylska, L, Clavane, EM et al. (1 more author) (2022) BACE1: More than just a β‐secretase. Obesity Reviews, 23 (7). e13430. ISSN 1467-7881

Taylor, HA orcid.org/0000-0003-3592-1857, Simmons, KJ orcid.org/0000-0003-4846-9097, Clavane, EM et al. (6 more authors) (2022) PTPRD and DCC Are Novel BACE1 Substrates Differentially Expressed in Alzheimer’s Disease: A Data Mining and Bioinformatics Study. International Journal of Molecular Sciences, 23 (9). 4568. ISSN 1661-6596

Al-Mubarak, BR, Bell, KFS, Chowdhry, S et al. (8 more authors) (2021) Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress. Redox Biology, 47. 102158. ISSN 2213-2317

Meakin, PJ orcid.org/0000-0002-8553-3863, Coull, BM, Tuharska, Z et al. (16 more authors) (2020) Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction. Journal of Clinical Investigation. ISSN 0021-9738

Botteri, G, Salvadó, L, Gumà, A et al. (14 more authors) (2019) Corrigendum to “The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling” [Metab Clin Exp 85 (2018) 59–75]. Metabolism, 96. pp. 101-102. ISSN 0026-0495

Botteri, G, Salvadó, L, Gumà, A et al. (14 more authors) (2018) The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling. Metabolism, 85. pp. 59-75. ISSN 0026-0495

Horsburgh, K, Wardlaw, JM, van Agtmael, T et al. (43 more authors) (2018) Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132 (8). pp. 851-868. ISSN 0143-5221

Mills, EL, Ryan, DG, Prag, HA et al. (32 more authors) (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 556 (7699). pp. 113-117. ISSN 0028-0836

Meakin, PJ orcid.org/0000-0002-8553-3863, Mezzapesa, A, Benabou, E et al. (9 more authors) (2018) The beta secretase BACE1 regulates the expression of insulin receptor in the liver. Nature Communications, 9 (1). 1306. ISSN 2041-1723

Meakin, PJ orcid.org/0000-0002-8553-3863, Jalicy, SM, Montagut, G et al. (13 more authors) (2018) Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice. Scientific Reports, 8 (1). 55.

McGuire, VA, Ruiz-Zorrilla Diez, T, Emmerich, CH et al. (11 more authors) (2016) Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation. Scientific Reports, 6 (1). 31159.

Bell, KFS, Al-Mubarak, B, Martel, M-A et al. (16 more authors) (2015) Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Nature Communications, 6. 7066. ISSN 2041-1723

Meakin, PJ orcid.org/0000-0002-8553-3863, Morrison, VL, Sneddon, CC et al. (7 more authors) (2015) Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation. PLoS ONE, 10 (9). e0138872. ISSN 1932-6203

Rzepecka, J, Pineda, MA, Al-Riyami, L et al. (10 more authors) (2015) Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome. Journal of Autoimmunity, 60. pp. 59-73. ISSN 0896-8411

Meakin, PJ orcid.org/0000-0002-8553-3863, Chowdhry, S, Sharma, RS et al. (7 more authors) (2014) Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance. Molecular and Cellular Biology, 34 (17). pp. 3305-3320. ISSN 0270-7306

Hamilton, DL, Findlay, JA, Montagut, G et al. (4 more authors) (2014) Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes. Diabetologia, 57 (8). pp. 1684-1692. ISSN 0012-186X

Watterson, KR, Bestow, D, Gallagher, J et al. (4 more authors) (2013) Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression. Neurosignals, 21 (1-2). pp. 28-41. ISSN 1424-862X

Meakin, PJ orcid.org/0000-0002-8553-3863, Harper, AJ, Hamilton, DL et al. (10 more authors) (2012) Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice. Biochemical Journal, 441 (1). pp. 285-296. ISSN 0264-6021

Book Section

Clavane, EM, Taylor, HA, Cubbon, RM orcid.org/0000-0001-7844-3600 et al. (1 more author) (2022) Endothelial Cell Fibrin Gel Angiogenesis Bead Assay. In: Benest, AV, (ed.) Angiogenesis: Methods and Protocols. Methods in Molecular Biology, 2441 . Springer , New York, USA , pp. 321-327. ISBN 978-1-0716-2058-8

Proceedings Paper

Meakin, PJ orcid.org/0000-0002-8553-3863, Elahi, ME, Brown, J et al. (2 more authors) (2022) The beta-secretase, BACE1, is a master regulator of vascular health. In: Acta Physiologica. Europhysiology 2022, 16-18 Sep 2022, Copenhagen. Wiley-Blackwell , p. 547.

Meakin, PJ orcid.org/0000-0002-8553-3863, Strivens, F, Khan, F et al. (1 more author) (2019) Beta-secretase 1 (BACE1) regulates insulin sensitivity in endothelial cells. In: Diabetic Medicine. Diabetes UK Professional Conference, 06-08 Mar 2019, Liverpool, UK. Wiley , p. 71.

Coull, BM, Allsop, DJP, Meakin, PJ orcid.org/0000-0002-8553-3863 et al. (2 more authors) (2019) Increased brain amyloid beta levels aggravate diet-induced obesity and Type 2 diabetes. In: Diabetic Medicine. Diabetes UK Professional Conference, 06-08 Mar 2019, Liverpool, UK. Wiley , p. 49.

Meakin, PJ orcid.org/0000-0002-8553-3863, Tuharska, Z, Gooding, KM et al. (4 more authors) (2018) Association between beta-amyloid, diabetes and endothelial function in humans. In: Diabetic Medicine. Diabetes UK Professional Conference 2018, 14-16 Mar 2018, London. Wiley , p. 87.