Items where authors include "Homan, E."
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Green, A.C. orcid.org/0000-0002-0175-1485, Marttila, P. orcid.org/0000-0002-0115-8067, Kiweler, N. orcid.org/0000-0001-7493-703X et al. (31 more authors) (2023) Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. Nature Metabolism, 5 (4). pp. 642-659. ISSN 2522-5812
Jemth, A.-S., Scaletti, E.R., Homan, E. et al. (3 more authors) (2022) Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir. Journal of Biological Chemistry, 298 (8). 102169. ISSN 0021-9258
Rehling, D., Zhang, S.M., Jemth, A.-S. et al. (15 more authors) (2021) Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity. Journal of Biological Chemistry, 296. 100568. ISSN 0021-9258
Jemth, A-S., Gustafsson, R., Bräutigam, L. et al. (9 more authors) (2018) MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP. Nucleic Acids Research, 46 (20). pp. 10888-10904. ISSN 0305-1048
Visnes, T., Cázares-Körner, A., Hao, W. et al. (37 more authors) (2018) Small-molecule inhibitor of OGG1 suppresses pro-inflammatory gene expression and inflammation. Science, 362 (6416). pp. 834-839. ISSN 0036-8075
Page, B.D.G., Valerie, N.C.K., Wright, R.H.G. et al. (22 more authors) (2018) Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nature Communications, 9 (1). 250. ISSN 2041-1723
Hagenkort, A., Paulin, C.B.J., Desroses, M. et al. (12 more authors) (2017) dUTPase inhibition augments replication defects of 5-Fluorouracil. Oncotarget, 8 (14). pp. 23713-23726.
Valerie, N.C.K., Hagenkort, A., Page, B.D.G. et al. (10 more authors) (2016) NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine. Cancer Research, 76 (18). pp. 5501-5511. ISSN 0008-5472
Proceedings Paper
Walter, M. orcid.org/0000-0003-3241-522X, Homan, E., Koolmeister, T. et al. (3 more authors) (2021) Development of small molecule NUDT22 inhibitors for uses in cancer. In: Medical Sciences Forum. IECC 2021: 1st International Electronic Conference on Cancers, 01-14 Feb 2021, Online. MDPI .