Items where authors include "Hautbergue, G.M."

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Number of items: 43.

Article

Mihaylov, S.R. orcid.org/0000-0001-6872-0635, Castelli, L.M., Lin, Y.-H. orcid.org/0000-0003-1576-4655 et al. (13 more authors) (2023) The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function. Nature Communications, 14. 5496.

Allen, S.P. orcid.org/0000-0003-4418-7375, Al Sultan, A., Kabucho Kibirige, E. et al. (13 more authors) (2023) A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations. Frontiers in Aging Neuroscience, 15. 1151848. ISSN 1663-4365

Bauer, C.S., Webster, C.P., Shaw, A.C. et al. (12 more authors) (2022) Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation. Frontiers in Cellular Neuroscience, 16. 1061559. ISSN 1662-5102

Marchi, P.M. orcid.org/0000-0002-8893-3790, Marrone, L., Brasseur, L. et al. (19 more authors) (2022) C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons. Life Science Alliance, 5 (9). e202101276. ISSN 2575-1077

Karyka, E., Berrueta Ramirez, N., Webster, C.P. orcid.org/0000-0003-4197-2036 et al. (11 more authors) (2022) SMN-deficient cells exhibit increased ribosomal DNA damage. Life Science Alliance, 5 (8). e202101145. ISSN 2575-1077

Cooper‐Knock, J., Julian, T.H., Feneberg, E. et al. (15 more authors) (2022) Atypical TDP-43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP. Brain Pathology. e13104. ISSN 1015-6305

Castelli, L.M. orcid.org/0000-0003-3620-4219, Benson, B.C., Huang, W.-P. et al. (2 more authors) (2022) RNA helicases in microsatellite repeat expansion disorders and neurodegeneration. Frontiers in Genetics, 13. 886563. ISSN 1664-8021

Benson, B.C., Shaw, P.J. orcid.org/0000-0002-8925-2567, Azzouz, M. orcid.org/0000-0001-6564-5967 et al. (2 more authors) (2021) Proteinopathies as hallmarks of impaired gene expression, proteostasis and mitochondrial function in amyotrophic lateral sclerosis. Frontiers in Neuroscience, 15. 783624.

Hautbergue, G.M. orcid.org/0000-0002-1621-261X, Cleary, J.D., Guo, S. et al. (1 more author) (2021) Therapeutic strategies for C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia. Current Opinion in Neurology, 34 (5). pp. 748-755. ISSN 1350-7540

Castelli, L.M., Cutillo, L., Souza, C.D.S. et al. (14 more authors) (2021) SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export : genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis. Molecular Neurodegeneration, 16 (1). 53.

Castelli, L.M., Huang, W.-P., Lin, Y.-H. et al. (2 more authors) (2021) Mechanisms of repeat-associated non-AUG translation in neurological microsatellite expansion disorders. Biochemical Society Transactions, 49 (2). pp. 775-792. ISSN 0300-5127

Gatto, N., Dos Santos Souza, C., Shaw, A.C. et al. (12 more authors) (2021) Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease. Aging Cell, 20 (1). e13281. ISSN 1474-9718

De Marco, M. orcid.org/0000-0002-9240-8067, Manca, R. orcid.org/0000-0003-1715-6442, Kirby, J. orcid.org/0000-0002-7468-5917 et al. (5 more authors) (2020) The association between polygenic hazard and markers of Alzheimer’s disease following stratification for APOE genotype. Current Alzheimer Research, 17 (7). pp. 667-679. ISSN 1567-2050

Myszczynska, M.A. orcid.org/0000-0003-0067-8500, Ojamies, P.N., Lacoste, A.M.B. et al. (6 more authors) (2020) Applications of machine learning to diagnosis and treatment of neurodegenerative diseases. Nature Reviews Neurology, 16. pp. 440-456. ISSN 1759-4758

López, K.L.R., Simpson, J.E. orcid.org/0000-0002-3753-4271, Watson, L.C. et al. (4 more authors) (2019) TIGAR inclusion pathology is specific for Lewy body diseases. Brain Research, 1706. pp. 218-223. ISSN 0006-8993

Cooper-Knock, J., Moll, T., Ramesh, T. et al. (26 more authors) (2019) Mutations in the glycosyltransferase domain of GLT8D1 are associated with familial amyotrophic lateral sclerosis. Cell Reports, 26 (9). 2298-2306.e5. ISSN 2211-1247

Varcianna, A.E., Myszczynska, M.A., Castelli, L.M. et al. (9 more authors) (2019) Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS. EBioMedicine, 40. pp. 626-635. ISSN 2352-3964

Shaw, M.P., Higginbottom, A. orcid.org/0000-0002-3246-6695, McGown, A. et al. (5 more authors) (2018) Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features. Acta Neuropathologica Communications, 6 (1). 125. ISSN 2051-5960

Iannitti, T., Scarrott, J., Likhite, S. et al. (12 more authors) (2018) Translating SOD1 gene silencing towards the clinic: A highly efficacious, off-target free and biomarker-supported strategy for familial ALS. Molecular Therapy : Nucleic Acids, 12. pp. 75-88. ISSN 2162-2531

Morgan, S.V., Garwood, C.J., Jennings, L. et al. (10 more authors) (2018) Proteomic and cellular localisation studies suggest non-tight junction cytoplasmic and nuclear roles for occludin in astrocytes. European Journal of Neuroscience, 47 (12). pp. 1444-1456. ISSN 0953-816X

Rust, A., Shah, S., Hautbergue, G.M. orcid.org/0000-0002-1621-261X et al. (1 more author) (2018) Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells. Toxins, 10 (7). 261. ISSN 2072-6651

Castelli, L.M., Lin, Y.H., Ferraiuolo, L. et al. (6 more authors) (2018) SRSF1-dependent nuclear export of C9ORF72 repeat-transcripts: targeting toxic gain-of-functions induced by protein sequestration as a selective therapeutic strategy for neuroprotection. Therapeutic Targets for Neurological Diseases, 4. e1619. ISSN 2376-0478

Cooper-Knock, J. orcid.org/0000-0002-0873-8689, Robins, H., Niedermoser, I. et al. (11 more authors) (2017) Targeted Genetic Screen in Amyotrophic Lateral Sclerosis Reveals Novel Genetic Variants with Synergistic Effect on Clinical Phenotype. Frontiers in Molecular Neuroscience , 10. 370. ISSN 1662-5099

Rust, A., Partridge, L.J., Davletov, B. orcid.org/0000-0003-4658-3275 et al. (1 more author) (2017) The Use of Plant-Derived Ribosome Inactivating Proteins in Immunotoxin Development: Past, Present and Future Generations. Toxins, 9 (11). 344. ISSN 2072-6651

Walker, C., Herranz-Martin, S., Karyka, E. et al. (19 more authors) (2017) C9orf72 Expansion Disrupts ATM-mediated Chromosomal Break Repair. Nature Neuroscience, 20 (9). pp. 1225-1235. ISSN 1097-6256

Hautbergue, G.M. orcid.org/0000-0002-1621-261X, Castelli, L.M., Ferraiuolo, L. et al. (23 more authors) (2017) SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits. Nature Communications, 8. 16063 (2017).

Stopford, M.J., Higginbottom, A., Hautbergue, G.M. et al. (14 more authors) (2017) C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten. Human Molecular Genetics, 26 (6). pp. 1133-1145. ISSN 0964-6906

Webster, C.P., Smith, E.F., Bauer, C.S. et al. (12 more authors) (2016) The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy. EMBO Journal, 35 (15). pp. 1656-1676.

Hautbergue, G.M. orcid.org/0000-0002-1621-261X (2016) Widespread RNA dysregulation in neurodegeneration: Challenges and Opportunities. Austin Neurology, 1 (1). 1002.

Cooper-Knock, J., Higginbottom, A., Stopford, M.J. et al. (7 more authors) (2015) Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy. Acta Neuropathologica, 130 (1). pp. 63-75. ISSN 0001-6322

Walsh, M.J., Cooper-Knock, J., Dodd, J.E. et al. (5 more authors) (2015) Invited Review: Decoding the pathophysiological mechanisms that underlie RNA dysregulation in neurodegenerative disorders: a review of the current state of the art. Neuropathology and Applied Neurobiology, 41 (2). pp. 109-134. ISSN 0305-1846

Snijders, A.P., Hautbergue, G.M., Bloom, A. et al. (9 more authors) (2015) Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA. RNA, 21 (3). 347 - 359. ISSN 1355-8382

Caballero-Lima, D., Hautbergue, G.M. orcid.org/0000-0002-1621-261X, Wilson, S.A. orcid.org/0000-0003-3073-258X et al. (1 more author) (2014) In C andida albicans hyphae, Sec2p is physically associated with SEC2 mRNA on secretory vesicles. Molecular Microbiology, 94 (4). pp. 828-842. ISSN 0950-382X

Cooper-Knock, J., Walsh, M.J., Higginbottom, A. et al. (9 more authors) (2014) Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions. Brain, 137. 2040 - 2051. ISSN 0006-8950

Tunnicliffe, R.B., Hautbergue, G.M. orcid.org/0000-0002-1621-261X, Wilson, S.A. orcid.org/0000-0003-3073-258X et al. (2 more authors) (2014) Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri ORF57 to the Mammalian Export Adaptor ALYREF. PLOS PATHOGENS, 10 (2). ARTN e1003907. ISSN 1553-7366

Viphakone, N., Hautbergue, G.M. orcid.org/0000-0002-1621-261X, Walsh, M. et al. (5 more authors) (2012) TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export. Nature Communications, 3. 1006. ISSN 2041-1723

Phelan, M.M., Goult, B.T., Clayton, J.C. et al. (3 more authors) (2012) The structure and selectivity of the SR protein SRSF2 RRM domain with RNA. Nucleic Acids Research, 40 (7). pp. 3232-3244. ISSN 0305-1048

Cruz-Migoni, A., Hautbergue, G.M. orcid.org/0000-0002-1621-261X, Artymiuk, P.J. et al. (25 more authors) (2011) A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A. Science, 334 (6057). pp. 821-824. ISSN 0036-8075

Jackson, B.R., Boyne, J.R., Noerenberg, M. et al. (7 more authors) (2011) An Interaction between KSHV ORF57 and UIF Provides mRNA-Adaptor Redundancy in Herpesvirus Intronless mRNA Export. PLOS Pathogens, 7 (7). e1002138. ISSN 1553-7366

Tunnicliffe, R.B., Hautbergue, G.M. orcid.org/0000-0002-1621-261X, Kalra, P. et al. (4 more authors) (2011) Structural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57. PLOS Pathogens, 7 (1). e1001244. ISSN 1553-7366

Hung, M.L., Hautbergue, G.M. orcid.org/0000-0002-1621-261X, Snijders, A.P.L. et al. (2 more authors) (2010) Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1. NUCLEIC ACIDS RES, 38 (10). pp. 3351-3361. ISSN 0305-1048

Book Section

Hautbergue, G.M. orcid.org/0000-0002-1621-261X (2017) RNA Nuclear Export: From Neurological Disorders to Cancer. In: El-Khamisy, S., (ed.) Personalised Medicine. Advances in Experimental Medicine and Biology (vol 1007). Springer . ISBN 978-3-319-60731-3

Proceedings Paper

Allen, S.P., Hall, B., Castelli, L. orcid.org/0000-0003-3620-4219 et al. (11 more authors) (2018) Inosine reverses motor neuron toxicity observed in amyotrophic lateral sclerosis patient astrocytes with an adenosine deaminase deficiency. In: Biochimica et Biophysica Acta (BBA) - Bioenergetics. 20th European Bioenergetics Conference, 25-30 Aug 2018, Budapest, Hungary. Elsevier BV , e23-e23.

This list was generated on Sat Mar 23 21:00:11 2024 GMT.