Items where authors include "Darton, T.C."
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Ashton, P.M. orcid.org/0000-0002-1545-9661, Chunga Chirambo, A., Meiring, J.E. orcid.org/0000-0001-9183-5174 et al. (32 more authors) (2024) Evaluating the relationship between ciprofloxacin prescription and non-susceptibility in Salmonella Typhi in Blantyre, Malawi: an observational study. The Lancet Microbe, 5 (3). e226-e234. ISSN 2666-5247
Harrison, T. orcid.org/0000-0001-8063-5564, Clark, J. and Darton, T.C. orcid.org/0000-0003-2209-9956 (2024) Less is more: uptake of recommended vaccines in a UK travel clinic. Journal of Infection, 88 (3). 106109. ISSN 0163-4453
Hardman, S.J., Shackley, F.M., Ugonna, K. et al. (5 more authors) (2023) Seasonal azithromycin use in paediatric protracted bacterial bronchitis does not promote antimicrobial resistance but does modulate the nasopharyngeal microbiome. International Journal of Molecular Sciences, 24 (22). 16053. ISSN 1661-6596
Barnes, M.V.C. orcid.org/0000-0001-5474-3262, Mandla, A., Smith, E. et al. (37 more authors) (2023) Human infection challenge in the pandemic era and beyond, HIC-Vac annual meeting report, 2022. Immunotherapy Advances, 3 (1). ltad024. ISSN 2732-4303
Barton, A. orcid.org/0000-0001-8313-8643, Hill, J., O'Connor, D. et al. (11 more authors) (2023) Early transcriptional responses to human enteric fever challenge. Infection and Immunity, 19 (10). e0010823. ISSN 0019-9567
Bear, A., Locke, T., Rowland-Jones, S. et al. (3 more authors) (2023) The immune evasion roles of Staphylococcus aureus protein A and impact on vaccine development. Frontiers in Cellular and Infection Microbiology, 13. 1242702. ISSN 2235-2988
Smith, C. orcid.org/0000-0001-7369-2034, Smith, E., Chiu, C. et al. (10 more authors) (2023) The Challenge Non-Typhoidal Salmonella (CHANTS) Consortium: Development of a non-typhoidal Salmonella controlled human infection model: Report from a consultation group workshop, 05 July 2022, London, UK [version 2; peer review: 2 approved]. Wellcome Open Research, 8. 111. ISSN 2398-502X
Olaru, I.D., Chingono, R.M.S., Bottomley, C. et al. (10 more authors) (2023) The effect of a comprehensive typhoid conjugate vaccine campaign on antimicrobial prescribing in children in Harare, Zimbabwe: a mixed methods study. The Lancet Global Health, 11 (9). E1422-E1431. ISSN 2214-109X
Fachrul, M. orcid.org/0000-0003-2199-5900, Karkey, A., Shakya, M. et al. (44 more authors) (2023) Direct inference and control of genetic population structure from RNA sequencing data. Communications Biology, 6 (1). 804. ISSN 2399-3642
Lee, I.T., Cosgrove, C.A., Moore, P. et al. (63 more authors) (2023) Omicron BA.1-containing mRNA-1273 boosters compared with the original COVID-19 vaccine in the UK: a randomised, observer-blind, active-controlled trial. The Lancet Infectious Diseases. ISSN 1473-3099
Kuehn, R., Stoesser, N., Eyre, D. et al. (3 more authors) (2022) Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins. Cochrane Database of Systematic Reviews, 2022 (11). CD010452. ISSN 1469-493X
Marsh, A.A., Magalhaes, M., Peeler, M. et al. (6 more authors) (2022) Characterizing altruistic motivation in potential volunteers for SARS-CoV-2 challenge trials. PLoS ONE, 17 (11). e0275823. ISSN 1932-6203
Toan, N.D., Darton, T.C. orcid.org/0000-0003-2209-9956, Huong, N.H.T. et al. (17 more authors) (2022) Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children’s hospital. PLOS Global Public Health, 2 (9). e0000875. ISSN 2767-3375
Salerno-Gonçalves, R., Fresnay, S., Magder, L. et al. (7 more authors) (2022) Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever. Cellular Immunology, 378. 104572. ISSN 0008-8749
Locke, T., Parsons, H., Briffa, N. et al. (3 more authors) (2022) A bundle of infection control measures reduces post-operative sternal wound infection due to Staphylococcus aureus but not Gram-negative bacteria : a retrospective analysis of 6,903 patient episodes. Journal of Hospital Infection, 126. pp. 21-28. ISSN 0195-6701
Colton, H. orcid.org/0000-0002-3287-4103, Hodgson, D., Hornsby, H. et al. (20 more authors) (2022) Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust. Wellcome Open Research, 6. 220.
Barton, A., Hill, J., Bibi, S. et al. (12 more authors) (2022) Genetic susceptibility to enteric fever in experimentally challenged human volunteers. Infection and Immunity, 90 (4). ISSN 0019-9567
Toan, N.D., Darton, T.C., Boinett, C.J. et al. (13 more authors) (2022) Clinical features, antimicrobial susceptibility patterns and genomics of bacteria causing neonatal sepsis in a children's hospital in Vietnam: protocol for a prospective observational study. BMJ Open, 8. e019611. ISSN 2044-6055
Khanam, F., Darton, T.C. orcid.org/0000-0003-2209-9956, Meiring, J.E. et al. (8 more authors) (2021) Salmonella Typhi stool shedding by enteric fever patients and asymptomatic chronic carriers in an endemic urban setting. Journal of Infectious Diseases, 224 (Supplement_7). S759-S763. ISSN 0022-1899
Meiring, J.E. orcid.org/0000-0001-9183-5174, Shakya, M., Khanam, F. et al. (20 more authors) (2021) Burden of enteric fever at three urban sites in Africa and Asia: a multicentre population-based study. The Lancet Global Health, 9 (12). e1688-e1696. ISSN 2572-116X
Colton, H. orcid.org/0000-0002-3287-4103, Greenfield, D.M. orcid.org/0000-0002-3733-2717, Snowden, J.A. orcid.org/0000-0001-6819-3476 et al. (6 more authors) (2021) Long-term survivors following autologous haematopoetic stem cell transplantation have significant defects in their humoral immunity against vaccine preventable diseases, years on from transplant. Vaccine, 39 (34). pp. 4778-4783. ISSN 0264-410X
Fernandez Lynch, H., Darton, T.C. orcid.org/0000-0003-2209-9956, Levy, J. et al. (7 more authors) (2021) Plumbing the depths of ethical payment for research participation. The American Journal of Bioethics, 21 (5). W8-W11. ISSN 1526-5161
Khanam, F., Darton, T.C. orcid.org/0000-0003-2209-9956, Ross, A.G.P. et al. (4 more authors) (2021) Case report : typhoid fever complicated by ileal perforation in an urban slum of Dhaka, Bangladesh. The American Journal of Tropical Medicine and Hygiene, 104 (5). pp. 1755-1757. ISSN 0002-9637
Rose, S.M. orcid.org/0000-0003-3717-0882, Schmit, V.L. orcid.org/0000-0002-9894-0505, Darton, T.C. orcid.org/0000-0003-2209-9956 et al. (6 more authors) (2021) Characterizing altruistic motivation in potential volunteers for SARS-CoV-2 challenge trials. medRxiv. (Submitted)
Lynch, H.F., Darton, T.C. orcid.org/0000-0003-2209-9956, Levy, J. et al. (7 more authors) (2021) Promoting ethical payment in human infection challenge studies. The American Journal of Bioethics, 21 (3). pp. 11-31. ISSN 1526-5161
Nguyen, L.C., Bakerlee, C.W., McKelvey, T.G. et al. (11 more authors) (2021) Evaluating use cases for human challenge trials in accelerating SARS-CoV-2 vaccine development. Clinical Infectious Diseases, 72 (4). pp. 710-715. ISSN 1058-4838
Jayasooriya, S., Mitchell, C., Balen, J. orcid.org/0000-0002-4736-8465 et al. (1 more author) (2020) Seasonal influenza programme expansion. BMJ, 371. m4713. ISSN 1759-2151
Gibani, M.M., Jin, C., Shrestha, S. et al. (22 more authors) (2020) Homologous and heterologous re-challenge with Salmonella Typhi and Salmonella Paratyphi A in a randomised controlled human infection model. PLOS Neglected Tropical Diseases, 14 (10). e0008783. ISSN 1935-2727
de Alwis, R., My Phuc, T., Yu Hang Bai, B. et al. (34 more authors) (2020) The influence of human genetic variation on early transcriptional responses and protective immunity following immunization with Rotarix vaccine in infants in Ho Chi Minh City in Vietnam : a study protocol for an open single-arm interventional trial [awaiting peer review]. Wellcome Open Research, 5. 246.
Yu, M., Darton, T.C. orcid.org/0000-0003-2209-9956 and Kimmelman, J. (2020) Decision analysis approach to risk/benefit evaluation in the ethical review of controlled human infection studies. Bioethics, 34 (8). pp. 764-770. ISSN 0269-9702
Rapaka, R.R, Wahid, R., Fresnay, S. et al. (7 more authors) (2020) Human Salmonella Typhi exposure generates differential multifunctional cross‐reactive T‐cell memory responses against Salmonella Paratyphi and invasive nontyphoidal Salmonella. Clinical & Translational Immunology, 9 (9). e1178. ISSN 2050-0068
Darton, T.C. orcid.org/0000-0003-2209-9956, Thi Hong Chau, T., Parry, C.M. et al. (11 more authors) (2020) The CIPAZ study protocol: an open label randomised controlled trial of azithromycin versus ciprofloxacin for the treatment of children hospitalised with dysentery in Ho Chi Minh City, Vietnam. Wellcome Open Research, 5. 214. ISSN 2398-502X
Baker, S., Blohmke, C.J., Maes, M. et al. (2 more authors) (2020) The current status of enteric fever diagnostics and implications for disease control. Clinical Infectious Diseases, 71 (Supplement_2). S64-S70. ISSN 1058-4838
Shah, S.K., Miller, F.G., Darton, T.C. orcid.org/0000-0003-2209-9956 et al. (19 more authors) (2020) Unnecessary hesitancy on human vaccine tests—Response. Science, 369 (6500). p. 151. ISSN 0036-8075
Shah, S.K., Miller, F.G., Darton, T.C. orcid.org/0000-0003-2209-9956 et al. (19 more authors) (2020) Ethics of controlled human infection to study COVID-19. Science, 368 (6493). pp. 832-834. ISSN 0036-8075
Carter, M.J., Gurung, P., Jones, C. et al. (22 more authors) (2020) Assessment of an antibody-in-lymphocyte supernatant assay for the etiological diagnosis of pneumococcal pneumonia in children. Frontiers in Cellular and Infection Microbiology, 9. 459.
Oguti, B., Gibani, M., Darlow, C. et al. (7 more authors) (2019) Factors influencing participation in controlled human infection models : a pooled analysis from six enteric fever studies [under peer review]. Wellcome Open Research, 4. 153.
Blohmke, C.J., Muller, J., Gibani, M.M. et al. (15 more authors) (2019) Diagnostic host gene signature for distinguishing enteric fever from other febrile diseases. EMBO Molecular Medicine, 11 (10). e10431. ISSN 1757-4676
Gibani, M.M., Voysey, M., Jin, C. et al. (13 more authors) (2018) The Impact of Vaccination and Prior Exposure on Stool Shedding of Salmonella Typhi and Salmonella Paratyphi in 6 Controlled Human Infection Studies. Clinical Infectious Diseases. ciy670. ISSN 1058-4838
Zellweger, R.M., Basnyat, B., Shrestha, P. et al. (10 more authors) (2018) Changing Antimicrobial Resistance Trends in Kathmandu, Nepal: A 23-Year Retrospective Analysis of Bacteraemia. Frontiers in Medicine, 5. 262. ISSN 2296-858X
Zhang, Y., Brady, A., Jones, C. et al. (9 more authors) (2018) Compositional and functional differences in the human gut microbiome correlate with clinical outcome following infection with wild-type Salmonella enterica serovar Typhi. mBio, 9 (3). e00686-18. ISSN 2150-7511
Darton, T.C., Thanh Tuyen, H., Chung The, H. et al. (10 more authors) (2018) Azithromycin resistance in Shigella spp. in Southeast Asia. Antimicrobial Agents and Chemotherapy, 62 (4). e01748-17. ISSN 0066-4804
Juel, H.B., Thomaides-Brears, H.B., Darton, T.C. orcid.org/0000-0003-2209-9956 et al. (12 more authors) (2018) Salmonella Typhi Bactericidal Antibodies Reduce Disease Severity but Do Not Protect against Typhoid Fever in a Controlled Human Infection Model. Frontiers in Immunology, 8. 1916.
Le Thi Phuong, T., Rattanavong, S., Vongsouvath, M. et al. (8 more authors) (2018) Non-typhoidal Salmonella serovars associated with invasive and non-invasive disease in the Lao People's Democratic Republic. Transactions of The Royal Society of Tropical Medicine and Hygiene, 111 (9). pp. 418-422. ISSN 0035-9203
Zellweger, R.M., Basnyat, B., Shrestha, P. et al. (10 more authors) (2017) A 23-year retrospective investigation of Salmonella Typhi and Salmonella Paratyphi isolated in a tertiary Kathmandu hospital. PLoS Neglected Tropical Diseases , 11 (11). e0006051. ISSN 1935-2727
Darton, T.C. orcid.org/0000-0003-2209-9956, Jones, C., Dongol, S. et al. (12 more authors) (2017) Assessment and Translation of the Antibody-in-Lymphocyte Supernatant (ALS) Assay to Improve the Diagnosis of Enteric Fever in Two Controlled Human Infection Models and an Endemic Area of Nepal. Frontiers in Microbiology, 8. 2031.
Blohmke, C.J., Hill, J., Darton, T.C. orcid.org/0000-0003-2209-9956 et al. (8 more authors) (2017) Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever. Frontiers in Immunology, 8. 1276. ISSN 1664-3224
Darton, T.C. orcid.org/0000-0003-2209-9956, Baker, S., Randall, A. et al. (18 more authors) (2017) Identification of novel serodiagnostic signatures of typhoid fever using a Salmonella proteome array. Frontiers in Microbiology, 8. 1794. ISSN 1664-302X
Meiring, J.E., Gibani, M., Basnyat, B. et al. (23 more authors) (2017) The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs: Accelerating the introduction of typhoid conjugate vaccines and reducing the global burden of enteric fever. Report from a meeting held on 26-27 October 2016, Oxford, UK. Vaccine, 35 (38). pp. 5081-5088. ISSN 0264-410X
Darton, T.C., Meiring, J.E. orcid.org/0000-0001-9183-5174, Tonks, S. et al. (18 more authors) (2017) The STRATAA study protocol: a programme to assess the burden of enteric fever in Bangladesh, Malawi and Nepal using prospective population census, passive surveillance, serological studies and healthcare utilisation surveys. BMJ Open, 7 (6). e016283.
Tran Vu Thieu, N., Trinh Van, T., Tran Tuan, A. et al. (26 more authors) (2017) An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever. Journal of Infection, 75 (2). pp. 104-114.
Berto, A. orcid.org/0000-0003-4005-9464, Day, J., Van Vinh Chau, N. et al. (4 more authors) (2017) Current challenges and possible solutions to improve access to care and treatment for hepatitis C infection in Vietnam: a systematic review. BMC Infectious Diseases, 17. 260.
Salerno-Goncalves, R., Luo, D., Fresnay, S. et al. (9 more authors) (2017) Challenge of humans with wild-type Salmonella enterica serovar Typhi elicits changes in the activation and homing characteristics of mucosal-associated invariant T cells. Frontiers in Immunology, 8. 398. ISSN 1664-3224
Fresnay, S., McArthur, M.A., Magder, L.S. et al. (8 more authors) (2017) Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model. Frontiers in Immunology, 8. 208.
Dobinson, H.C., Gibani, M.M., Jones, C. et al. (21 more authors) (2017) Evaluation of the clinical and microbiological response to Salmonella Paratyphi A infection in the first paratyphoid human challenge model. Clinical Infectious Diseases. ISSN 1058-4838
Darton, T.C. orcid.org/0000-0003-2209-9956, Zhou, L., Blohmke, C.J. et al. (4 more authors) (2017) Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia. Journal of Infection. ISSN 0163-4453
Darton, T.C. orcid.org/0000-0003-2209-9956, Jones, C., Blohmke, C.J. et al. (20 more authors) (2016) Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a. PLoS Negl Trop Dis, 10 (8). e0004926. ISSN 1935-2727
Grande, A.J., Reid, H., Thomas, E. et al. (2 more authors) (2016) Tourniquet Test for Dengue Diagnosis: Systematic Review and Meta-analysis of Diagnostic Test Accuracy. PLoS Neglected Tropical Diseases, 10 (8). e0004888. ISSN 1935-2727
Toapanta, F.R., Bernal, P.J., Fresnay, S. et al. (9 more authors) (2016) Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease. PLoS Neglected Tropical Diseases, 10 (6). e0004766. ISSN 1935-2727
Blohmke, C.J., Darton, T.C. orcid.org/0000-0003-2209-9956, Jones, C. et al. (24 more authors) (2016) Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever. Journal of Experimental Medicine, 213 (6). pp. 1061-1077. ISSN 0022-1007
Zhou, L., Jones, C., Gibani, M.M. et al. (6 more authors) (2016) Development and Evaluation of a Blood Culture PCR Assay for Rapid Detection of Salmonella Paratyphi A in Clinical Samples. PLoS One, 11 (3). e0150576. ISSN 1932-6203
Fresnay, S., McArthur, M.A., Magder, L. et al. (8 more authors) (2016) Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans. Journal of Translational Medicine, 14. 62. ISSN 1479-5876
Gibani, M.M., Jin, C., Darton, T.C. et al. (1 more author) (2015) Control of Invasive Salmonella Disease in Africa: Is There a Role for Human Challenge Models? Clinical Infectious Diseases, 61 (4). S266 - S271. ISSN 1058-4838
Darton, T.C., Blohmke, C.J., Giannoulatou, E. et al. (7 more authors) (2015) Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans. PLoS Neglected Tropical Diseases, 9 (9). e0004029. - . ISSN 1935-2727
Toapanta, F.R., Bernal, P.J., Fresnay, S. et al. (9 more authors) (2015) Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease. PLoS Neglected Tropical Diseases, 9 (6). e0003837. ISSN 1935-2727
McArthur, M.A., Fresnay, S., Magder, L.S. et al. (9 more authors) (2015) Activation of salmonella typhi-specific regulatory T cells in typhoid disease in a wild-type s. Typhi challenge model. PLoS Pathogens, 11 (5). e1004914. ISSN 1553-7366
Jones, C., Darton, T.C. and Pollard, A.J. (2014) Why the development of effective typhoid control measures requires the use of human challenge studies. Frontiers in Microbiology, 5. 707. .
Reynolds, C.J., Jones, C., Blohmke, C.J. et al. (7 more authors) (2014) The serodominant secreted effector protein of Salmonella, SseB, is a strong CD4 antigen containing an immunodominant epitope presented by diverse HLA class II alleles. Immunology, 143 (3). 438 - 446.
Waddington, C.S., Darton, T.C., Angus, B. et al. (1 more author) (2014) Reply to Farmakiotis et al. Clinical Infectious Diseases, 59 (8). 1198 - 1199. ISSN 1058-4838
Waddington, C.S., Darton, T.C., Jones, C. et al. (16 more authors) (2014) An outpatient, ambulant-design, controlled human infection model using escalating doses of Salmonella Typhi challenge delivered in sodium bicarbonate solution. Clinical Infectious Diseases, 58 (9). 1230 - 1240. ISSN 1058-4838
Chapman, A.L., Darton, T.C. and Foster, R.A. (2013) Managing and monitoring tuberculosis using web-based tools in combination with traditional approaches. Clinical Epidemiology, 5. 465 - 473. ISSN 1179-1349