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Number of items: 61.


Bauer, CC, Minard, A, Pickles, IB et al. (9 more authors) (2020) Xanthine-based photoaffinity probes allow assessment of ligand engagement by TRPC5 channels. RSC Chemical Biology. ISSN 2633-0679

Shi, J, Hyman, AJ, De Vecchis, D et al. (8 more authors) (2020) Sphingomyelinase disables inactivation in endogenous PIEZO1 channels. Cell Reports. ISSN 2211-1247 (In Press)

Wu, Z, Suppo, J-S, Tumova, S et al. (10 more authors) (2020) Bridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition. ACS Medicinal Chemistry Letters, 11 (9). pp. 1711-1716. ISSN 1948-5875

Caspi, T, Straw, S, Cheng, C et al. (14 more authors) (2020) Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy. Journal of the American Heart Association. ISSN 2047-9980

Cheng, CW, Beech, DJ and Wheatcroft, SB (2020) Advantages of CEMiTool for gene co-expression analysis of RNA-seq data. Computers in Biology and Medicine. 103975. p. 103975. ISSN 0010-4825

Benitah, J-P, Beech, DJ and Sabourin, J (2020) Response by Benitah et al to Letter Regarding Article, “Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload”. Circulation, 141 (22). e839-e840. ISSN 0009-7322

Caolo, V, Debant, M, Endesh, N et al. (6 more authors) (2020) Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells. eLife, 9. ISSN 2050-084X

Maqbool, A, Watt, N, Haywood, N et al. (17 more authors) (2020) Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance related vascular damage. American Journal of Physiology: Cell Physiology. ISSN 0363-6143

Evans, EL, Povstyan, OV, De Vecchis, D et al. (9 more authors) (2020) RBCs prevent rapid PIEZO1 inactivation and expose slow deactivation as a mechanism of DHS. Blood. ISSN 0006-4971

Bartoli, F, Bailey, MA, Rode, B et al. (23 more authors) (2020) Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload. Circulation, 141 (3). pp. 199-216. ISSN 0009-7322

Blythe, NM, Muraki, K, Ludlow, MJ et al. (12 more authors) (2019) Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion. Journal of Biological Chemistry, 294 (46). pp. 17395-17408. ISSN 0021-9258

Deivasikamani, V, Dhayalan, S, Abudushalamu, Y et al. (12 more authors) (2019) Piezo1 channel activation mimics high glucose as a stimulator of insulin release. Scientific Reports, 9. 16876. ISSN 2045-2322

Beech, DJ and Kalli, AC (2019) Force Sensing by Piezo Channels in Cardiovascular Health and Disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 39 (11). pp. 2228-2239. ISSN 1079-5642

Minard, A, Bauer, CC, Chuntharpursat-Bon, E et al. (8 more authors) (2019) Potent, selective, and subunit‐dependent activation of TRPC5 channels by a xanthine derivative. British Journal of Pharmacology, 176 (20). pp. 3924-3938. ISSN 0007-1188

Miteva, KT, Pedicini, L, Wilson, LA et al. (9 more authors) (2019) Rab46 integrates Ca2+ and histamine signalling to regulate selective cargo release from Weibel-Palade bodies. Journal of Cell Biology, 218 (7). pp. 2232-2246. ISSN 0021-9525

Morley, LC, Beech, DJ, Walker, JJ et al. (1 more author) (2019) Emerging concepts of shear stress in placental development and function. Molecular Human Reproduction, 25 (6). pp. 329-339. ISSN 1360-9947

Rode, B, Yuldasheva, NY, Baxter, PD et al. (7 more authors) (2019) TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice. Scientific Reports, 9. 773. ISSN 2045-2322

Beech, DJ (2019) Triskelion channels might bring Star Wars to the global problem of hypertension. Cell Calcium, 77. pp. 77-78. ISSN 0143-4160

Thakore, P, Brain, SD and Beech, DJ (2018) Correspondence: Challenging a proposed role for TRPC5 in aortic baroreceptor pressure-sensing. Nature Communications, 9 (1). 1245. ISSN 2041-1723

Morley, LC, Shi, J, Gaunt, HJ et al. (7 more authors) (2018) Piezo1 channels are mechanosensors in human fetoplacental endothelial cells. Molecular Human Reproduction, 24 (10). pp. 510-520. ISSN 1360-9947

Lepannetier, S, Gualdani, R, Tempesta, S et al. (12 more authors) (2018) Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory. Frontiers in Cellular Neuroscience, 12. e318. ISSN 1662-5102

Rubaiy, HN, Ludlow, MJ, Siems, K et al. (5 more authors) (2018) Tonantzitlolone is a Nanomolar Potency Activator of TRPC1/4/5 Channels. British Journal of Pharmacology, 175 (16). pp. 3361-3368. ISSN 0007-1188

Cheung, SY, Henrot, M, Al-Saad, M et al. (17 more authors) (2018) TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A. Oncotarget, 9 (51). pp. 29634-29643. ISSN 1949-2553

Rode, B, Bailey, MA, Marthan, R et al. (2 more authors) (2018) ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension. Physiology, 33 (4). pp. 261-268. ISSN 1548-9213

Minard, A, Bauer, CC, Wright, DJ et al. (4 more authors) (2018) Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease. Cells, 7 (6). 52. ISSN 2073-4409

Pedicini, L, Miteva, KT, Hawley, V et al. (7 more authors) (2018) Homotypic endothelial nanotubes induced by wheat germ agglutinin and thrombin. Scientific Reports, 8. 7569. ISSN 2045-2322

Evans, EL, Cuthbertson, K, Endesh, N et al. (8 more authors) (2018) Yoda1 analogue (Dooku1) which antagonizes Yoda1‐evoked activation of Piezo1 and aortic relaxation. British Journal of Pharmacology, 175 (10). pp. 1744-1759. ISSN 0007-1188

Beech, DJ (2018) Endothelial Piezo1 channels as sensors of exercise. Journal of Physiology, 596 (6). pp. 979-984. ISSN 0022-3751

Beech, DJ and Xiao, B (2018) Piezo channel mechanisms in health and disease. The Journal of Physiology, 596 (6). pp. 965-967. ISSN 0022-3751

Rubaiy, HN, Seitz, T, Hahn, S et al. (8 more authors) (2018) Identification of an (−)‐englerin A analogue, which antagonizes (−)‐englerin A at TRPC1/4/5 channels. British Journal of Pharmacology, 175 (5). pp. 830-839. ISSN 0007-1188

Muraki, K, Ohnishi, K, Takezawa, A et al. (10 more authors) (2017) Na⁺ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells. Scientific Reports, 7 (1). 16988. ISSN 2045-2322

Webster, PJ, Littlejohns, AT, Gaunt, HJ et al. (3 more authors) (2017) AZD1775 Induces Toxicity Through Double-Stranded DNA Breaks Independently of Chemotherapeutic Agents in p53-Mutated Colorectal Cancer Cells. Cell Cycle, 16 (22). pp. 2176-2182. ISSN 1538-4101

Watt, NT, Gage, MC, Patel, PA et al. (15 more authors) (2017) Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase–Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance. Diabetes, 66 (11). pp. 2808-2821. ISSN 0012-1797

Rubaiy, HN, Ludlow, MJ, Bon, RS et al. (1 more author) (2017) Pico145 - powerful new tool for TRPC1/4/5 channels. Channels, 11 (5). pp. 362-364. ISSN 1933-6950

Rode, B, Shi, J, Endesh, N et al. (22 more authors) (2017) Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance. Nature Communications, 8. 350. ISSN 2041-1723

Rubaiy, HN, Ludlow, MJ, Henrot, M et al. (18 more authors) (2017) Picomolar, selective and subtype specific small-molecule inhibition of TRPC1/4/5 channels. Journal of Biological Chemistry, 292. pp. 8158-8173. ISSN 0021-9258

Webster, PJ, Littlejohns, AT, Beech, DJ et al. (1 more author) (2017) AZD1775 induces toxicity through double-stranded DNA breaks independent of 5-FU activity in P53 mutated colorectal cancer cells. British Journal of Surgery, 104 (S3). pp. 43-44. ISSN 0007-1323

Viswambharan, VH, Yuldasheva, NY, Sengupta, A et al. (18 more authors) (2017) Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signalling Loop. Circulation Research, 120 (5). pp. 784-798. ISSN 0009-7330

Webster, PJ, Littlejohns, AT, Gaunt, HJ et al. (17 more authors) (2017) Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases. Oncotarget, 8 (26). pp. 42288-42299. ISSN 1949-2553

Ludlow, MJ, Gaunt, HJ, Rubaiy, HN et al. (5 more authors) (2017) (-)-Englerin A-evoked Cytotoxicity is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase. Journal of Biological Chemistry, 292 (2). pp. 723-731. ISSN 0021-9258

Gaunt, HJ, Vasudev, NS and Beech, DJ (2016) Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics. European Biophysics Journal, 45 (7). pp. 611-620. ISSN 0175-7571

Naylor, J, Minard, A, Gaunt, HJ et al. (17 more authors) (2016) Natural and synthetic flavonoid modulation of TRPC5 channels. British Journal of Pharmacology, 173 (3). pp. 562-574. ISSN 0007-1188

Li, J, Bruns, A-F, Hou, B et al. (18 more authors) (2015) Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor. Arteriosclerosis, Thrombosis, and Vascular Biology, 35 (9). 1987 - 1994. ISSN 1079-5642

Akbulut, Y, Gaunt, HJ, Muraki, K et al. (12 more authors) (2015) (−)-Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels. Angewandte Chemie International Edition, 54 (12). pp. 3787-3791. ISSN 1433-7851

Wilson, LA, McKeown, L, Tumova, S et al. (2 more authors) (2015) Expression of a long variant of CRACR2A that belongs to the Rab GTPase protein family in endothelial cells. Biochemical and Biophysical Research Communications, 456 (1). pp. 398-402. ISSN 0006-291X

Ye, M, Yang, W, Ainscough, JF et al. (11 more authors) (2014) TRPM2 channel deficiency prevents delayed cytosolic Zn²⁺ accumulation and CA1 pyramidal neuronal death after transient global ischemia. Cell Death and Disease, 5. e1541. ISSN 2041-4889

Li, J, Hou, B, Tumova, S et al. (25 more authors) (2014) Piezo1 integration of vascular architecture with physiological force. Nature, 515. pp. 279-282. ISSN 0028-0836

Cubbon, RM, Yuldasheva, NY, Viswambharan, H et al. (20 more authors) (2014) Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential. Stem Cells, 32 (10). 2714 - 2723. ISSN 1066-5099

Zou, J, Ainscough, JF, Yang, W et al. (6 more authors) (2013) A differential role of macrophage TRPM2 channels in Ca2+ signaling and cell death in early responses to H2O2. American Journal of Physiology: Cell Physiology, 305 (1). C61 - C69. ISSN 0363-6143

Sukumar, P, Viswambharan, H, Imrie, H et al. (14 more authors) (2013) Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance–Related Endothelial Cell Dysfunction. Diabetes, 62 (6). pp. 2130-2134. ISSN 0012-1797

Amer, MS, McKeown, L, Tumova, S et al. (14 more authors) (2013) Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands. British Journal of Pharmacology, 168 (6). pp. 1445-1455. ISSN 0007-1188

Imrie, H, Viswambharan, H, Sukumar, P et al. (16 more authors) (2012) Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice. Diabetes, 61 (9). pp. 2359-2368. ISSN 0012-1797

Li, J, McKeown, L, Ojelabi, O et al. (5 more authors) (2011) Nanomolar potency and selectivity of a Ca 2+ release-activated Ca 2+ channel inhibitor against store-operated Ca 2+ entry and migration of vascular smooth muscle cells. British Journal of Pharmacology, 164 (2). pp. 382-393. ISSN 0007-1188

Abbas, A, Imrie, H, Viswambharan, H et al. (14 more authors) (2011) The Insulin-like Growth Factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes, 60 (8). pp. 2169-2178. ISSN 0012-1797

Dedman, AM, Majeed, Y, Tumova, S et al. (8 more authors) (2011) TRPC1 transcript variants, inefficient nonsense-mediated decay and low up-frameshift-1 in vascular smooth muscle cells. BMC Molecular Biology, 12 (1). 30. ISSN 1471-2199

Cheong, A, Li, J, Sukumar, P et al. (7 more authors) (2011) Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers. Cardiovascular Research, 89 (2). pp. 282-289. ISSN 0008-6363

Ciurtin, C, Majeed, Y, Naylor, J et al. (4 more authors) (2010) TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan. BMC Musculoskeletal Disorders, 11 (1). 111. ISSN 1471-2474

Wong, C-O, Sukumar, P, Beech, DJ et al. (1 more author) (2010) Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells. Pflügers Archiv - European Journal of Physiology, 460 (1). pp. 121-130. ISSN 0031-6768

Conference or Workshop Item

Cheng, C, Deivasikamani, V, Beech, DJ et al. (1 more author) (2019) Association of Piezo1 Variants With Hypertension in UK Biobank Participants. In: American Heart Association's 2019 Scientific Sessions, 16-19 Nov 2019, Philadelphia, USA.

Proceedings Paper

Evans, EL, Shi, J, Bettale, M et al. (2 more authors) (2019) Haematological Characterisation of Mice with Piezo1 Gain-Of-Function Mutation. In: Biophysical Journal. Biophysical Society, 63rd Anual Meeting, 02-06 Mar 2019, Baltimore, Maryland. Biophysical Society , 243A-243A.

Rode, B, Yuldasheva, NY, Baxter, P et al. (3 more authors) (2016) Protective effects arising from inhibition of TRPC1/5 ion channel permeation in hypercholesterolaemic mice. In: Heart. BSCR Autumn 2016 - Cardiovascular Disease and Diabetes, 05-06 Sep 2016. BMJ Publishing Group , A6-A6.

This list was generated on Sat Oct 17 16:56:04 2020 BST.