Items where authors include "Bayliss, R"

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Number of items: 47.

Article

Elshatlawy, M, Sampson, J, Clarke, K et al. (1 more author) (2023) EML4-ALK biology and drug resistance in Non-Small Cell Lung Cancer: a new phase of discoveries. Molecular Oncology, 17 (6). pp. 950-963. ISSN 1574-7891

Piovesana, M, Wood, AKM, Smith, DP et al. (8 more authors) (2023) A point mutation in the kinase domain of CRK10 leads to xylem vessel collapse and activation of defence responses in Arabidopsis. Journal of Experimental Botany, 74 (10). pp. 3104-3121. ISSN 0022-0957

Arter, C orcid.org/0000-0001-9323-5738, Trask, L, Ward, S et al. (2 more authors) (2022) Structural features of the protein kinase domain and targeted binding by small molecule inhibitors. Journal of Biological Chemistry, 298 (8). 102247. ISSN 0021-9258

Papageorgiou, S, Pashley, SL, O’Regan, L et al. (3 more authors) (2022) Alternative Treatment Options to ALK Inhibitor Monotherapy for EML4-ALK-Driven Lung Cancer. Cancers, 14 (14). 3452. ISSN 2072-6694

Lucken, K, O'Regan, L, Choi, J et al. (5 more authors) (2022) EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity. Molecular Cancer Research, 20 (6). pp. 854-866. ISSN 1541-7786

Lucken, K, O'Regan, L, Choi, J et al. (5 more authors) (2022) EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity. Molecular Cancer Research, 20 (6). pp. 854-866. ISSN 1541-7786

Batchelor, M, Dawber, RS orcid.org/0000-0002-9802-2691, Wilson, AJ orcid.org/0000-0001-9852-6366 et al. (1 more author) (2022) α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif. Biochemical Journal, 479 (5). pp. 687-700. ISSN 0264-6021

Tomlinson, LJ, Batchelor, M orcid.org/0000-0001-6338-5698, Sarsby, J et al. (5 more authors) (2022) Exploring the Conformational Landscape and Stability of Aurora A Using Ion-Mobility Mass Spectrometry and Molecular Modeling. Journal of the American Society for Mass Spectrometry, 33 (3). pp. 420-435. ISSN 1044-0305

Sampson, J orcid.org/0000-0002-0147-6014, Ju, H-M, Song, J-Y et al. (3 more authors) (2022) A Polytherapy Strategy Using Vincristine and ALK Inhibitors to Sensitise EML4-ALK-Positive NSCLC. Cancers, 14 (3). 779. ISSN 2072-6694

Kakade, P, Ojha, H, Raimi, OG et al. (12 more authors) (2022) Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells. Open Biology, 12 (1). 210264. ISSN 2046-2441

Sampson, J orcid.org/0000-0002-0147-6014, Richards, MW orcid.org/0000-0003-1108-2825, Choi, J et al. (2 more authors) (2021) Phase‐separated foci of EML4‐ALK facilitate signalling and depend upon an active kinase conformation. EMBO Reports, 22 (12). e53693. ISSN 1469-221X

Roeschert, I, Poon, E, Henssen, AG et al. (18 more authors) (2021) Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma. Nature Cancer, 2 (3). pp. 312-326. ISSN 2662-1347

Ryan, EL, Shelford, J, Massam-Wu, T et al. (2 more authors) (2021) Defining endogenous TACC3–chTOG–clathrin–GTSE1 interactions at the mitotic spindle using induced relocalization. Journal of Cell Science, 134 (3). jcs255794. ISSN 0021-9533

Wolpaw, AJ, Bayliss, R orcid.org/0000-0003-0604-2773, Büchel, G et al. (22 more authors) (2021) Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers. Cancer Research. ISSN 0008-5472

Poon, E, Liang, T, Jamin, Y et al. (40 more authors) (2020) Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma. Journal of Clinical Investigation. ISSN 0021-9738

Matheson, CJ, Coxon, CR, Bayliss, R orcid.org/0000-0003-0604-2773 et al. (13 more authors) (2020) 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase. RSC Medicinal Chemistry, 11 (6). pp. 707-731. ISSN 2632-8682

Byrne, M, Nasir, N, Basmadjian, C et al. (7 more authors) (2020) Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine. Biochemical Journal. ISSN 0264-6021

Rombi, F, Bayliss, R orcid.org/0000-0003-0604-2773, Tuplin, A orcid.org/0000-0003-2524-707X et al. (1 more author) (2020) The journey of Zika to the developing brain. Molecular Biology Reports, 47 (4). pp. 3097-3115. ISSN 0301-4851

O'Regan, L, Barone, G, Adib, R et al. (10 more authors) (2020) EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7. Journal of Cell Science. jcs.241505. jcs.241505-jcs.241505. ISSN 0021-9533

Newton, R, Waszkowycz, B, Seewooruthun, C et al. (14 more authors) (2020) Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase. ACS Medicinal Chemistry Letters. acsmedchemlett.9b00615. ISSN 1948-5875

Tsuchiya, Y, Byrne, DP, Burgess, SG orcid.org/0000-0003-0361-0691 et al. (21 more authors) (2020) Covalent Aurora A regulation by the metabolic integrator coenzyme A. Redox Biology, 28. 101318. ISSN 2213-2317

Adib, R, Montgomery, JM, Atherton, J et al. (8 more authors) (2019) Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression. Science signaling, 12 (594). ARTN eaaw2939. ISSN 1945-0877

Zhang, R, McIntyre, PJ, Collins, PM et al. (6 more authors) (2019) Construction of a Shape‐Diverse Fragment Set: Design, Synthesis and Screen against Aurora‐A Kinase. Chemistry - A European Journal, 25 (27). pp. 6831-6839. ISSN 0947-6539

Colombano, G, Caldwell, JJ, Matthews, TP et al. (18 more authors) (2019) Binding to an unusual inactive kinase conformation by highly selective inhibitors of inositol-requiring enzyme 1a kinase-endoribonuclease. Journal of Medicinal Chemistry, 62 (5). pp. 2447-2465. ISSN 0022-2623

Ocasio, CA, Warkentin, AA, McIntyre, PJ et al. (5 more authors) (2018) Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases. ACS Chemical Biology, 13 (10). pp. 2956-2965. ISSN 1554-8929

Yeoh, S and Bayliss, R orcid.org/0000-0003-0604-2773 (2018) New tools for evaluating protein tyrosine sulfation and carbohydrate sulfation. Biochemical Journal, 475 (19). pp. 3035-3037. ISSN 0264-6021

Rostkova, E, Burgess, SG, Bayliss, R orcid.org/0000-0003-0604-2773 et al. (1 more author) (2018) Solution NMR assignment of the C-terminal domain of human chTOG. Biomolecular NMR Assignments, 12 (2). pp. 221-224. ISSN 1874-2718

Mukherjee, M orcid.org/0000-0002-3615-7574, Sabir, S, O'Regan, L et al. (8 more authors) (2018) Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release. Science signaling, 11 (543). eaao2464. ISSN 1945-0877

Fearon, D, Westwood, IM, Van Montfort, RLM et al. (3 more authors) (2018) Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition. Bioorganic and Medicinal Chemistry, 26 (11). pp. 3021-3029. ISSN 0968-0896

Burgess, SG orcid.org/0000-0003-0361-0691, Mukherjee, M, Sabir, S orcid.org/0000-0003-0611-6226 et al. (10 more authors) (2018) Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix. EMBO Journal, 37 (8). e97902. ISSN 0261-4189

Buchel, G, Carstensen, A, Mak, K-Y et al. (16 more authors) (2017) Association with Aurora-A controls N-MYC-dependent promoter escape and pause release of RNA polymerase II during the cell cycle. Cell Reports, 21 (12). pp. 3483-3497. ISSN 2211-1247

Fry, AM, Bayliss, R orcid.org/0000-0003-0604-2773 and Roig, J (2017) Mitotic regulation by NEK kinase networks. Frontiers in Cell and Developmental Biology, 5 (DEC). 102. ISSN 2296-634X

Sabir, SR orcid.org/0000-0003-0611-6226, Yeoh, S, Jackson, G et al. (1 more author) (2017) EML4-ALK variants: biological and molecular properties, and the implications for patients. Cancers, 9 (9). 118. ISSN 2072-6694

Sampson, J, O'Regan, L, Dyer, MJS et al. (2 more authors) (2017) Hsp72 and Nek6 cooperate to cluster amplified centrosomes in cancer cells. Cancer Research, 77 (18). pp. 4785-4796. ISSN 0008-5472

Bayliss, R orcid.org/0000-0003-0604-2773, Burgess, SG and McIntyre, PJ (2017) Switching Aurora-A kinase on and off at an allosteric site. The FEBS Journal, 284 (18). pp. 2947-2954. ISSN 1742-464X

Chavali, PL, Stojic, L, Meredith, LW et al. (13 more authors) (2017) Neurodevelopmental protein Musashi 1 interacts with the Zika genome and promotes viral replication. Science, 357 (6346). pp. 83-88. ISSN 0036-8075

Bayliss, R orcid.org/0000-0003-0604-2773, Burgess, SG, Leen, E et al. (1 more author) (2017) A moving target: structure and disorder in pursuit of Myc inhibitors. Biochemical Society Transactions, 45 (3). pp. 709-717. ISSN 0300-5127

Woo, CG, Seo, S, Kim, SW et al. (8 more authors) (2017) Differential protein stability and clinical responses of EML4 - ALKfusion variants to various ALK inhibitors in advanced ALK - rearranged non-small cell lung cancer. Annals of Oncology, 28 (4). mdw693. pp. 791-797. ISSN 0923-7534

Rennie, YK, McIntyre, PJ, Akindele, T et al. (2 more authors) (2016) A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix. ACS Chemical Biology, 11 (12). pp. 3383-3390. ISSN 1554-8929

Burgess, SG, Grazia Concilio, M, Bayliss, R orcid.org/0000-0003-0604-2773 et al. (1 more author) (2016) Detection of Ligand-induced Conformational Changes in the Activation Loop of Aurora-A Kinase by PELDOR Spectroscopy. ChemistryOpen, 5 (6). pp. 531-534.

Richards, MW orcid.org/0000-0003-1108-2825, Burgess, S orcid.org/0000-0003-0361-0691, Poon, E et al. (4 more authors) (2016) Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors. Proceedings of the National Academy of Sciences, 113 (48). pp. 13726-13731. ISSN 0027-8424

Mitcheson, DF, Bottrill, AR, Carr, K et al. (8 more authors) (2016) A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase. Malaria Journal, 15. 535. ISSN 1475-2875

Fry, AM, O'Regan, L, Montgomery, J et al. (2 more authors) (2016) EML proteins in microtubule regulation and human disease. Biochemical Society Transactions, 44 (5). pp. 1281-1288. ISSN 0300-5127

Hall, G, Cullen, E, Sawmynaden, K et al. (11 more authors) (2016) Structure of a potential therapeutic antibody bound to Interleukin-16 (IL-16): mechanistic insights and new therapeutic opportunities. Journal of Biological Chemistry, 291 (32). pp. 16840-16848. ISSN 0021-9258

Burgess, SG orcid.org/0000-0003-0361-0691, Oleksy, A, Cavazza, T et al. (4 more authors) (2016) Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain. Open Biology, 6 (7). 160089. ISSN 2046-2441

Bayliss, R orcid.org/0000-0003-0604-2773, Choi, J, Fennell, DA et al. (2 more authors) (2016) Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs. Cellular and Molecular Life Sciences, 73 (6). pp. 1209-1224. ISSN 1420-682X

Proceedings Paper

Mukherjee, M, Sampson, J, Sabir, S et al. (8 more authors) (2017) Mitotic phosphorylation of Hsp72 uncouples ATP binding from substrate release and clusters amplified centrosomes in cancer cells. In: Molecular Biology of the Cell. ASCB | EMBO 2017 Meeting, 02-06 Dec 2017, Philadelphia, PA. American Society for Cell Biology , T-361-T-362.

This list was generated on Sat Mar 23 06:26:36 2024 GMT.