Koudijs, M.J., den Broeder, M.J., Groot, E. et al. (1 more author) (2008) Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway. BMC Developmental Biology, 8 (15). ISSN 1471-213X
Abstract
Aberrant activation of the Hedgehog (Hh) signaling pathway in different organisms has shown the importance of this family of morphogens during development. Genetic screens in zebrafish have assigned specific roles for Hh in proliferation, differentiation and patterning, but mainly as a result of a loss of its activity. We attempted to fully activate the Hh pathway by removing both receptors for the Hh proteins, called Patched1 and 2, which are functioning as negative regulators in this pathway
Metadata
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| Copyright, Publisher and Additional Information: | © 2008 Koudijs et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Dates: |
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| Institution: | The University of Sheffield |
| Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
| Depositing User: | Sherpa Assistant |
| Date Deposited: | 09 May 2008 15:41 |
| Last Modified: | 09 May 2008 15:41 |
| Published Version: | http://dx.doi.org/10.1186/1471-213X-8-15 |
| Status: | Published |
| Publisher: | Biomed Central Ltd |
| Refereed: | Yes |
| Identification Number: | https://doi.org/10.1186/1471-213X-8-15 |
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