Role of genetic polymorphisms in tumour angiogenesis

Abstract

Angiogenesis plays a crucial role in the development, growth and spread of solid tumours. Pro- and anti-angiogenic factors are abnormally expressed in tumours, influencing tumour angiogenesis, growth and progression. Polymorphisms in genes encoding angiogenic factors or their receptors may alter protein expression and/or activity. This article reviews the literature to determine the possible role of angiogenesis-related polymorphisms in cancer. Further research studies in this potentially crucial area of tumour biology are proposed.

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Authors/Creators:	Balasubramanian, S.P. https://orcid.org/0000-0001-5953-2843 Brown, N.J. https://orcid.org/0000-0002-2100-1905 Reed, M.W.R.
Copyright, Publisher and Additional Information:	© 2002 Cancer Research UK. From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
Keywords:	Tumour angiogenesis; genetic polymorphism(s)
Dates:	Accepted: 4 September 2002 Published: 4 November 2002
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals
Depositing User:	Symplectic Sheffield
Date Deposited:	03 May 2016 10:38
Last Modified:	03 May 2016 10:38
Published Version:	http://dx.doi.org/10.1038/sj.bjc.6600625
Status:	Published
Publisher:	Cancer Research UK
Refereed:	Yes
Identification Number:	https://doi.org/10.1038/sj.bjc.6600625

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Role of genetic polymorphisms in tumour angiogenesis

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